(Q37313489)

19 August 2017

Do cleavages of amides by serine proteases occur through a stepwise pathway involving tetrahedral intermediates? (English)

1 reference

19 August 2017

M. Komiyama

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A284381

22 February 2023

M. L. Bender

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A284381

22 February 2023

language of work or name

English

0 references

publication date

1 February 1979

1 reference

PMCID

382987

full work available at URL

19 August 2017

https://europepmc.org/articles/PMC382987

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A284381

https://europepmc.org/articles/PMC382987?pdf=render

22 February 2023

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A284381

https://pnas.org/doi/pdf/10.1073/pnas.76.2.557

22 February 2023

1 reference

Crossref

DOI

10.1073/PNAS.76.2.557

https://api.crossref.org/works/10.1073/PNAS.76.2.557

Proceedings of the National Academy of Sciences of the United States of America

22 February 2023

published in

1 reference

19 August 2017

76

1 reference

19 August 2017

557-560

1 reference

19 August 2017

2

1 reference

Influence of Leaving-Group Electronic Effect on alpha-Chymotrypsin: Catalytic Constants of Specific Substrates

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=382987

Pretransition-state protonation and the rate of chymotrypsin catalysis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=382987

Acylation of alpha-chymotrypsin by oxygen and sulfur esters of specific substrates: kinetic evidence for a tetrahedral intermediate

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=382987

Re-examination of the charge relay system in subtilisin comparison with other serine proteases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=382987

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=382987

Kinetics of hydrolysis of p-nitrophenyl thiolacetate by chymotrypsin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=382987

The mechanism of the aminolysis of acetate esters.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=382987

Studies of the activity of chymotrypsin.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=382987

Carbon nuclear magnetic resonance studies of the histidine residue in alpha-lytic protease. Implications for the catalytic mechanism of serine proteases.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=382987

X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=382987

Detection of a tetrahedral intermediate in the trypsin-catalysed hydrolysis of specific ring-activated anilides

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=382987

THE REACTIVITY OF NUCLEOPHILIC REAGENTS WITH FUROYL-CHYMOTRYPSIN

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=382987

Mechanism of hydrolysis by serine proteases: direct determination of the pKa's of aspartyl-102 and aspartyl-194 in bovine trypsin using difference infrared spectroscopy

2 September 2018

1 reference

12 December 2020

Mechanism of action of serine proteases: tetrahedral intermediate and concerted proton transfer

1 reference

12 December 2020

Chymotrypsin catalysis. Evidence for a new intermediate, III

1 reference

12 December 2020

Transition state charge distribution in reactions of an acetyltyrosylchymotrypsin intermediate

1 reference

12 December 2020

Mechanism of the .alpha.-chymotrypsin-catalyzed hydrolysis of specific amide substrates

1 reference

12 December 2020

Nitrogen isotope effects on the chymotrypsin-catalyzed hydrolysis of N-acetyl-L-tryptophanamide

1 reference

12 December 2020

Chymotrypsin catalysis. Evidence for a new intermediate. II

1 reference

12 December 2020

Mechanism of the .alpha.-chymotrypsin-catalyzed hydrolysis of amides. pH dependence of kc and km. kinetic detection of an intermediate

1 reference

12 December 2020

Identification of the rate-limiting step in the chymotrypsin-catalyzed hydrolysis of N-acetyl-L-tryptophanamide

1 reference

12 December 2020

Chymotrypsin-catalyzed phenyl ester hydrolysis. Evidence for electrophilic assistance on carbonyl oxygen

1 reference

12 December 2020

Acyl-transfer reactions of amides and esters with alcohols and thiols. Reference system for the serine and cysteine proteinases. Nitrogen protonation of amides and amide-imidate equilibriums

1 reference

12 December 2020

Chymotrypsin catalysis. Evidence for a new intermediate

1 reference

12 December 2020

Participation of an Acidic Group in the Chymotrypsin Catalysis***

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.76.2.557

1 reference

19 August 2017

0 references

1 reference

19 August 2017

1 reference

PMCID

382987