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BMPs oppose Math1 in cerebellar development and in medulloblastoma.
scientific article published on March 2008
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scholarly article
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Europe PubMed Central
PMC publication ID
2731664
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347086%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 January 2020
title
BMPs oppose Math1 in cerebellar development and in medulloblastoma
(English)
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stated in
Europe PubMed Central
PMC publication ID
2731664
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347086%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 January 2020
main subject
medulloblastoma
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author
Matthew R Grimmer
series ordinal
1
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Europe PubMed Central
PMC publication ID
2731664
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347086%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 January 2020
William A Weiss
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2
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Europe PubMed Central
PMC publication ID
2731664
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347086%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 January 2020
author name string
Matthew R Grimmer
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1
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Europe PubMed Central
PMC publication ID
2731664
retrieved
19 August 2017
William A Weiss
series ordinal
2
1 reference
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Europe PubMed Central
PMC publication ID
2731664
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19 August 2017
language of work or name
English
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publication date
1 March 2008
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Europe PubMed Central
PMC publication ID
2731664
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347086%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 January 2020
published in
Genes & Development
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stated in
Europe PubMed Central
PMC publication ID
2731664
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347086%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 January 2020
volume
22
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Europe PubMed Central
PMC publication ID
2731664
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347086%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 January 2020
issue
6
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stated in
Europe PubMed Central
PMC publication ID
2731664
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347086%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 January 2020
page(s)
693-699
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Europe PubMed Central
PMC publication ID
2731664
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347086%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 January 2020
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Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development
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Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
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Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum
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Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway
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Signaling by bone morphogenetic proteins and Smad1 modulates the postnatal differentiation of cerebellar cells
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Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene
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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
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Bone morphogenetic proteins-2 and -4 attenuate apoptosis in a cerebellar primitive neuroectodermal tumor cell line
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The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched
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26 June 2018
Math1 is essential for genesis of cerebellar granule neurons.
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26 June 2018
Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc.
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2 September 2018
N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.
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2 September 2018
The roof plate regulates cerebellar cell-type specification and proliferation.
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2 September 2018
Genetic analyses demonstrate that bone morphogenetic protein signaling is required for embryonic cerebellar development.
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2 September 2018
Migration from a mitogenic niche promotes cell-cycle exit.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
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2 September 2018
Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
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2 September 2018
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
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2 September 2018
Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
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2 September 2018
Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
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2 September 2018
A molecular fingerprint for medulloblastoma.
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
retrieved
2 September 2018
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
retrieved
2 September 2018
Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
retrieved
2 September 2018
Type I bone morphogenetic protein receptors are expressed on cerebellar granular neurons and a constitutively active form of the type IA receptor induces cerebellar abnormalities.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
retrieved
2 September 2018
Medulloblastoma growth inhibition by hedgehog pathway blockade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
retrieved
2 September 2018
Overexpression of MATH1 disrupts the coordination of neural differentiation in cerebellum development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
retrieved
2 September 2018
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
retrieved
2 September 2018
The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
retrieved
2 September 2018
Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
retrieved
2 September 2018
Generation of cerebellar granule neurons in vivo by transplantation of BMP-treated neural progenitor cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2731664
retrieved
2 September 2018
Identifiers
DOI
10.1101/GAD.1657808
1 reference
stated in
Europe PubMed Central
PMC publication ID
2731664
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347086%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 January 2020
PMC publication ID
2731664
1 reference
stated in
Europe PubMed Central
PMC publication ID
2731664
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347086%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 January 2020
PubMed publication ID
18347086
1 reference
stated in
Europe PubMed Central
PMC publication ID
2731664
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347086%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 January 2020
ResearchGate publication ID
5505562
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