(Q37323369)

English

A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation

scientific article published on 31 July 2006

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scholarly article

1 reference

Europe PubMed Central

19 August 2017

A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation (English)

1 reference

Europe PubMed Central

19 August 2017

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cannabinoid receptor

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author name string

Aaron M D'Antona

1

1 reference

Europe PubMed Central

19 August 2017

Kwang H Ahn

2

1 reference

Europe PubMed Central

19 August 2017

Lei Wang

3

1 reference

Europe PubMed Central

19 August 2017

Dale F Mierke

4

1 reference

Europe PubMed Central

19 August 2017

Jean Lucas-Lenard

5

1 reference

Europe PubMed Central

19 August 2017

Debra A Kendall

6

1 reference

Europe PubMed Central

19 August 2017

language of work or name

0 references

publication date

31 July 2006

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

1108

1 reference

Europe PubMed Central

19 August 2017

1

1 reference

Europe PubMed Central

19 August 2017

1-11

1 reference

Europe PubMed Central

19 August 2017

Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

6 September 2017

Efficacy in CB1 receptor-mediated signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

6 September 2017

An Aromatic Microdomain at the Cannabinoid CB1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

6 September 2017

GPCRDB information system for G protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

6 September 2017

International Union of Pharmacology. XXVII. Classification of cannabinoid receptors

1 reference

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6 September 2017

Endocannabinoid signaling in the brain

1 reference

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6 September 2017

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

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6 September 2017

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

1 reference

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6 September 2017

C5a receptor activation. Genetic identification of critical residues in four transmembrane helices

1 reference

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6 September 2017

Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation

1 reference

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6 September 2017

Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor.

1 reference

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6 September 2017

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

1 reference

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6 September 2017

Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors

1 reference

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6 September 2017

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

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6 September 2017

Molecular cloning of a human cannabinoid receptor which is also expressed in testis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

6 September 2017

Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells

1 reference

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6 September 2017

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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6 September 2017

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1 reference

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6 September 2017

Chemically distinct ligands promote differential CB1 cannabinoid receptor-Gi protein interactions.

1 reference

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14 September 2017

Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

14 September 2017

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

28 September 2017

Constitutive precoupling to G(i) and increased agonist potency in the alpha(2B)-adrenoceptor

1 reference

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26 June 2018

Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

26 June 2018

Influence of G protein type on agonist efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

26 June 2018

Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability.

1 reference

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26 June 2018

Mutations that induce constitutive activation and mutations that impair signal transduction modulate the basal and/or agonist-stimulated internalization of the Lutropin/Choriogonadotropin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

26 June 2018

A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty

1 reference

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26 June 2018

Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

26 June 2018

Identification of a conserved switch residue responsible for selective constitutive activation of the beta2-adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

26 June 2018

Ligand binding and modulation of cyclic AMP levels depend on the chemical nature of residue 192 of the human cannabinoid receptor 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

26 June 2018

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

26 June 2018

Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733829

26 June 2018

Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands

1 reference

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26 June 2018

The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

1 reference

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2 September 2018

Toward the active conformations of rhodopsin and the beta2-adrenergic receptor

1 reference

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2 September 2018

D2 dopamine receptors modulate Galpha-subunit coupling of the CB1 cannabinoid receptor

1 reference

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2 September 2018

Integrity of extracellular loop 1 of the human cannabinoid receptor 1 is critical for high-affinity binding of the ligand CP 55,940 but not SR 141716A

1 reference

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2 September 2018

Mutagenesis and modelling of the alpha(1b)-adrenergic receptor highlight the role of the helix 3/helix 6 interface in receptor activation.

1 reference

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2 September 2018

Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.

1 reference

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2 September 2018

Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors

1 reference

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2 September 2018

Involvement of the carboxyl terminus of the third intracellular loop of the cannabinoid CB1 receptor in constitutive activation of Gs.

1 reference

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2 September 2018

Differential receptor-G-protein coupling evoked by dissimilar cannabinoid receptor agonists.

1 reference

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2 September 2018

Ligand-induced domain motion in the activation mechanism of a G-protein-coupled receptor.

1 reference

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2 September 2018

Signaling through the muscarinic receptor-adenylate cyclase system of the heart is buffered against GTP over a range of concentrations.

1 reference

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2 September 2018

G(i) activator region of alpha(2A)-adrenergic receptors: distinct basic residues mediate G(i) versus G(s) activation

1 reference

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12 December 2020

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Characterization of the molecular motions of constitutively active G protein-coupled receptors for parathyroid hormone

1 reference

https://pubmed.ncbi.nlm.nih.gov/16879811

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Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16879811

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based on heuristic

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Phospholipase participation in cannabinoid-induced release of free arachidonic acid

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https://pubmed.ncbi.nlm.nih.gov/16879811

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A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16879811

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Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16879811

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A three-state receptor model: predictions of multiple agonist pharmacology for the same receptor type

1 reference

https://pubmed.ncbi.nlm.nih.gov/16879811

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The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16879811

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Identifiers

10.1016/J.BRAINRES.2006.05.042

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

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