(Q37349825)

19 August 2017

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title

Glucose sensing and the pathogenesis of obesity and type 2 diabetes (English)

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19 August 2017

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B Thorens

1

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19 August 2017

language of work or name

English

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publication date

1 December 2008

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International Journal of Obesity

19 August 2017

published in

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19 August 2017

volume

32 Suppl 6

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19 August 2017

page(s)

S62-71

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https://scigraph.springernature.com/pub.10.1038/ijo.2008.208

19 August 2017

exact match

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cites work

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Portal glucose infusion in the mouse induces hypoglycemia: evidence that the hepatoportal glucose sensor stimulates glucose utilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Functional and chemical anatomy of the afferent vagal system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Demonstration of the influence of an hepatic glucosensitive mechanism on food-intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Neural network of glucose monitoring system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

A new ATP-sensitive K+ channel-independent mechanism is involved in glucose-excited neurons of mouse arcuate nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Brain glucose sensing: a subtle mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Glucose responding neurons in the nucleus tractus solitarius of the rat: In vitro study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Characteristics of glycemia-sensitive neurons in the nucleus tractus solitarii: possible involvement in nutritional regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Effects of estradiol on glucoprivic transactivation of catecholaminergic neurons in the female rat caudal brainstem

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Convergence of hepatoportal glucose-sensitive afferent signals to glucose-sensitive units within the nucleus of the solitary tract.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

2-Mercaptoacetate and 2-deoxy-D-glucose induce Fos-like immunoreactivity in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Hypoglycemia in diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Novel glucosensor for hypoglycemic detection localized to the portal vein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Portal vein afferents are critical for the sympathoadrenal response to hypoglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Primacy of liver glucosensors in the sympathetic response to progressive hypoglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

The role of liver glucosensors in the integrated sympathetic response induced by deep hypoglycemia in dogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Effect of vagal cooling on the counterregulatory response to hypoglycemia induced by a low dose of insulin in the conscious dog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Celiac-superior mesenteric ganglionectomy, but not vagotomy, suppresses the sympathoadrenal response to insulin-induced hypoglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Hypoglycemic detection at the portal vein is mediated by capsaicin-sensitive primary sensory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

The forebrain is not essential for sympathoadrenal hyperglycemic response to glucoprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Subgroups of hindbrain catecholamine neurons are selectively activated by 2-deoxy-D-glucose induced metabolic challenge.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Evidence that carotid bodies play an important role in glucoregulation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Oxygen and glucose sensing by carotid body glomus cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Evidence that extrapancreatic GLUT2-dependent glucose sensors control glucagon secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain--an immunohistochemical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Intraventricular alloxan eliminates feeding elicited by 2-deoxyglucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Third ventricular alloxan reversibly impairs glucose counterregulatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Melanocortins and body weight: a tale of two receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Glucostatic mechanism of regulation of food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

On-line continuous measurement of blood glucose and meal pattern in free-feeding rats: the role of glucose in meal initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Infusion of 2-deoxy-D-glucose into the hepatic-portal system causes eating: evidence for peripheral glucoreceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Intrameal hepatic-portal infusion of glucose reduces spontaneous meal size in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Glucose transporter 2 (GLUT 2): expression in specific brain nuclei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Distribution of glucokinase, glucose transporter GLUT2, sulfonylurea receptor-1, glucagon-like peptide-1 receptor and neuropeptide Y messenger RNAs in rat brain by quantitative real time RT-PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Immunocytochemical localization of the glucose transporter 2 (GLUT2) in the adult rat brain. II. Electron microscopic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Hypothalamic ependymal-glial cells express the glucose transporter GLUT2, a protein involved in glucose sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Co-localization of GLUT1 and GLUT4 in the blood-brain barrier of the rat ventromedial hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Fourth ventricular alloxan injection causes feeding but not hyperglycemia in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Islet beta cell failure in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

The role for endoplasmic reticulum stress in diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Central administration of oleic acid inhibits glucose production and food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Molecular disruption of hypothalamic nutrient sensing induces obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Hypothalamic K(ATP) channels control hepatic glucose production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

C75 inhibits food intake by increasing CNS glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

A role for hypothalamic malonyl-CoA in the control of food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Intracerebroventricular infusion of a triglyceride emulsion leads to both altered insulin secretion and hepatic glucose production in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Beta oxidation in the brain is required for the effects of non-esterified fatty acids on glucose-induced insulin secretion in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Effects of oleic acid on distinct populations of neurons in the hypothalamic arcuate nucleus are dependent on extracellular glucose levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Subunit stoichiometry of the pancreatic β-cell ATP-sensitive K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Participation of Hepatic Glucoreceptors in the Control of Intake of Food

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

Hepatic gene regulation by glucose and polyunsaturated fatty acids: a role for ChREBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

GLUT2 in pancreatic and extra-pancreatic gluco-detection (review).

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Glucose sensing by the hepatoportal sensor is GLUT2-dependent: in vivo analysis in GLUT2-null mice

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Afferent impulse discharges from glucoreceptors in the liver of the guinea pig

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Metabolic sensors mediate hypoglycemic detection at the portal vein

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

A portal-arterial glucose concentration gradient as a signal for an insulin-dependent net glucose uptake in perfused rat liver

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Solitary tract nucleus sensitivity to moderate changes in glucose level

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Interplay of nutrients and hormones in the regulation of glucagon release

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Effect of hepatic denervation on the counterregulatory response to insulin-induced hypoglycemia in the dog

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Counterregulation during hypoglycemia is directed by widespread brain regions

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Glucoreceptors Controlling Feeding and Blood Glucose: Location in the Hindbrain

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Fall in blood glucose level precedes meal onset in free-feeding rats

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Feeding induced by intracerebroventricular 2-deoxy-D-glucose in the rat

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Regulation of tension in skinned muscle fibers: effect of high concentrations of Mg-ATP

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Influences of hepatic portal receptors on hypothalamic feeding and satiety centers

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Localization of glucokinase-like immunoreactivity in the rat lower brain stem: for possible location of brain glucose-sensing mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2008.208

7 January 2021

Identifiers

DOI

10.1038/IJO.2008.208

1 reference

19 August 2017

1 reference