(Q37353936)

English

Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: is the CpG island methylator phenotype the 5-fluorouracil-responsive subgroup?

scientific article published on 18 December 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

1 reference

Europe PubMed Central

Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: is the CpG island methylator phenotype the 5-fluorouracil-responsive subgroup? (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

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based on heuristic

inferred from title

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based on heuristic

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based on heuristic

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author name string

Barry Iacopetta

1

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

Kazuyuki Kawakami

2

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

Toshiaki Watanabe

3

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

publication date

18 December 2008

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

International Journal of Clinical Oncology

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

13

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

498-503

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

https://scigraph.springernature.com/pub.10.1007/s10147-008-0854-3

0 references

Late onset and high incidence of colon cancer of the mutator phenotype with hypermethylated hMLH1 gene in women

1 reference

https://api.crossref.org/works/10.1007%2FS10147-008-0854-3

21 January 2018

Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low expression of gamma-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age and sex are independent predictors of 5-fluorouracil toxicity. Analysis of a large scale phase III trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CpG island methylator phenotype in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haematological and non-haematological toxicity after 5-fluorouracil and leucovorin in patients with advanced colorectal cancer is significantly associated with gender, increasing age and cycle number. Tomudex International Study Group.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical uses of microsatellite instability testing in colorectal cancer: an ongoing challenge

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation of the DPYD promoter: an alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination of O6-methylguanine-DNA methyltransferase and thymidylate synthase for the prediction of fluoropyrimidine efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classification of colorectal cancer based on correlation of clinical, morphological and molecular features

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant methylation of DPYD promoter, DPYD expression, and cellular sensitivity to 5-fluorouracil in cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant methylation of p16 predicts candidates for 5-fluorouracil-based adjuvant therapy in gastric cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognosis in DNA mismatch repair deficient colorectal cancer: are all MSI tumours equivalent?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between microsatellite instability, response and survival in palliative patients with colorectal cancer undergoing first-line chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prospective evaluation of fluorouracil chemotherapy based on the genetic makeup of colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydropyrimidine dehydrogenase: its role in 5-fluorouracil clinical toxicity and tumor resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relevance of tumoral folylpolyglutamate synthetase and reduced folates for optimal 5-fluorouracil efficacy: experimental data

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-frequency microsatellite instability predicts better chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV sporadic colorectal cancer after palliative bowel resection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival after adjuvant 5-FU treatment for stage III colon cancer in hereditary nonpolyposis colorectal cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA methylation and sensitivity to antimetabolites in cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predictive value of microsatellite instability for benefit from adjuvant fluorouracil chemotherapy in colorectal cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRAF mutation and gene methylation frequencies of colorectal tumours with microsatellite instability increase markedly with patient age.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased folylpolyglutamate synthetase expression: a novel mechanism of fluorouracil resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age and gender affect DNMT3a and DNMT3b expression in human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumoral-reduced folates and clinical resistance to fluorouracil-based treatment in head and neck cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypermethylation of O6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased folylpolyglutamate synthetase activity in tumors resistant to fluorouracil-folinic acid treatment: clinical data

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Fluorouracil: mechanisms of action and clinical strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsatellite instability and colorectal cancer prognosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular predictors of survival after adjuvant chemotherapy for colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic regulation of chemosensitivity to 5-fluorouracil and cisplatin by zebularine in oral squamous cell carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19093176

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10147-008-0854-3

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

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