(Q37358006)

English

IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain

scientific article published on August 1996

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

0 references

author name string

R L Palmer-Crocker

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

C C Hughes

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

J S Pober

3

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

language of work or name

0 references

publication date

1 August 1996

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

98

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

604-609

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Cytokine signal transduction

1 reference

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6 September 2017

HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons

1 reference

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6 September 2017

Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor

1 reference

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6 September 2017

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor

1 reference

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6 September 2017

Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction

1 reference

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6 September 2017

Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function

1 reference

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6 September 2017

Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

An interleukin-4-induced transcription factor: IL-4 Stat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Interferon-alpha and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-gamma activation site-like sequence upstream of the I epsilon exon in a human B cell line. Evidence for the involvement of J

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Interleukin 4 signals through two related pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Human vascular endothelial cells in culture. Growth and DNA synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and -independent binding mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

6 September 2017

Interleukin 13 elicits a subset of the activities of its close relative interleukin 4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

14 September 2017

Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

28 September 2017

Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

28 September 2017

Characterization and comparison of the interleukin 13 receptor with the interleukin 4 receptor on several cell types

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

28 September 2017

Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

26 June 2018

Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

26 June 2018

IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

26 June 2018

An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

26 June 2018

Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

26 June 2018

Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

26 June 2018

Interleukin-4 induces the synthesis and secretion of MCP-1/JE by human endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

26 June 2018

IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

26 June 2018

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

2 September 2018

Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507467

2 September 2018

IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor, or IFN-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of vascular cell adhesion molecule 1 on human dermal microvascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 controls the selective endothelium-driven transmigration of eosinophils from allergic individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting effects of interferon γ and interleukin 4 on responses of human vascular endothelial cells to tumour necrosis factor α

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 induction of VCAM-1 on endothelial cells involves activation of a protein tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variability among human umbilical vein endothelial cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human endothelial cells: use of heparin in cloning and long-term serial cultivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 and IL-13 exhibit comparable abilities to reduce pyrogen-induced expression of procoagulant activity in endothelial cells and monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-13 induces proliferation, Ig isotype switching, and Ig synthesis by immature human fetal B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of endothelial and mesothelial cell function by interleukin-13: selective induction of vascular cell adhesion molecule-1 and amplification of interleukin-6 production

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8698849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI118829

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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