(Q37360013)

English

Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.

scientific article published on September 1996

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scholarly article

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19 October 2019

Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera (English)

1 reference

Europe PubMed Central

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19 October 2019

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ChEBI release 2020-05-28

Patrick Dansette

6

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19 October 2019

author name string

M A Robin

1

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19 October 2019

M Maratrat

2

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19 October 2019

M Le Roy

3

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19 October 2019

F P Le Breton

4

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19 October 2019

E Bonierbale

5

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19 October 2019

F Ballet

7

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19 October 2019

D Mansuy

8

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19 October 2019

D Pessayre

9

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19 October 2019

language of work or name

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publication date

1 September 1996

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19 October 2019

Journal of Clinical Investigation

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19 October 2019

98

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19 October 2019

1471-1480

1 reference

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19 October 2019

6

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19 October 2019

Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

6 September 2017

Selective reentry of recycling cell surface glycoproteins to the biosynthetic pathway in human hepatocarcinoma HepG2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

6 September 2017

Decrease in hepatic cytochrome P-450 by cobalt. Evidence for a role of cobalt protoporphyrin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

6 September 2017

A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

6 September 2017

Antibody mediated hepatocyte injury in methyl dopa induced hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

6 September 2017

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

6 September 2017

Immune mechanisms in tienilic acid associated hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

6 September 2017

Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

6 September 2017

Interactions of colchicine with tubulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

6 September 2017

Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

6 September 2017

Autoantibodies against cytochromes P450: role in human diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

14 September 2017

Role of reactive metabolites in drug-induced hepatitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

28 September 2017

Serum antibodies from halothane hepatitis patients react with the rat endoplasmic reticulum protein ERp72.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

28 September 2017

The cytoplasmic and N-terminal transmembrane domains of cytochrome P450 contain independent signals for retention in the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

28 September 2017

The time courses of intracellular transport of some secretory proteins of rat liver are not affected by an induced acute phase response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

26 June 2018

Effect of caffeine and reduced temperature (20 degrees C) on the organization of the pre-Golgi and the Golgi stack membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

26 June 2018

Bile acid transport into hepatocyte smooth endoplasmic reticulum vesicles is mediated by microsomal epoxide hydrolase, a membrane protein exhibiting two distinct topological orientations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

26 June 2018

Association of anti-58 kDa endoplasmic reticulum antibodies with halothane hepatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

26 June 2018

Immunological studies on the mechanism of halothane-induced hepatotoxicity: immunohistochemical evidence of trifluoroacetylated hepatocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

26 June 2018

Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

26 June 2018

Presence of covalently bound metabolites on rat hepatocyte plasma membrane proteins after administration of isaxonine, a drug leading to immunoallergic hepatitis in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

26 June 2018

Detection of human hepatitis anti-liver kidney microsomes (LKM2) autoantibodies on rat liver sections is predominantly due to reactivity with rat liver P-450 IIC11

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

26 June 2018

Post-Golgi membrane traffic: brefeldin A inhibits export from distal Golgi compartments to the cell surface but not recycling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

26 June 2018

Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507575

2 September 2018

Ticrynafen-associated hepatic injury: analysis of 340 cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of the proline-rich region following signal-anchor sequence in the formation of correct conformation of microsomal cytochrome P-450s

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane topology of liver microsomal cytochrome P450 2B4 determined via monoclonal antibodies directed to the halt-transfer signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of dihydralazine with cytochromes P4501A: a possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interleukin-2 receptor down-regulates the expression of cytochrome P450 in cultured rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of functional cytochrome P-450 on isolated rat hepatocyte plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI118936

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8823314%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8823314%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8823314%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

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