(Q37366496)

English

JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis

scientific article published on September 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

author name string

Dong Oh Moon

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Mun Ock Kim

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Chang Hee Kang

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Jae Dong Lee

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Yung Hyun Choi

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Gi Young Kim

6

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

publication date

1 September 2009

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Experimental and Molecular Medicine

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

41

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

9

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

665-677

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

https://scigraph.springernature.com/pub.10.3858/emm.2009.41.9.073

0 references

Transcription of the protein kinase C-delta gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin

1 reference

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6 September 2017

Modulating the bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer

1 reference

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6 September 2017

Toward a comprehensive model for induced endoreduplication.

1 reference

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6 September 2017

Fortuitous convergences: the beginnings of JUN

1 reference

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6 September 2017

AP-1 in cell proliferation and survival

1 reference

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6 September 2017

Waiting for anaphase: Mad2 and the spindle assembly checkpoint

1 reference

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6 September 2017

Cell cycle checkpoints and their inactivation in human cancer

1 reference

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6 September 2017

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

1 reference

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6 September 2017

Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner

1 reference

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6 September 2017

p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption

1 reference

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6 September 2017

Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication

1 reference

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6 September 2017

Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

1 reference

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6 September 2017

Cell cycle checkpoints: preventing an identity crisis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753660

6 September 2017

DNA topoisomerases

1 reference

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6 September 2017

The stress-activated protein kinase subfamily of c-Jun kinases

1 reference

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6 September 2017

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

1 reference

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6 September 2017

Inactivation of Bcl-2 by phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753660

6 September 2017

Checkpoints: controls that ensure the order of cell cycle events

1 reference

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6 September 2017

Mechanism of action of taxol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753660

6 September 2017

The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753660

14 September 2017

Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753660

14 September 2017

Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent

1 reference

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14 September 2017

Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2753660

14 September 2017

Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis

1 reference

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28 September 2017

p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells

1 reference

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28 September 2017

Clinical toxicities encountered with paclitaxel (Taxol).

1 reference

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Application of fluorescence in situ hybridisation to study the relationship between cytotoxicity, chromosome aberrations, and changes in chromosome number after treatment with the topoisomerase II inhibitor amsacrine

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Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.

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p21WAF1 is dynamically associated with JNK in human T-lymphocytes during cell cycle progression.

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Paclitaxel pharmacology and other tumor types.

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Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

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Endoreduplication of human smooth muscle cells induced by 2-methoxyestradiol: a role for cyclin-dependent kinase 2.

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Cisplatin-induced endoreduplication in CHO cells: DNA damage and inhibition of topoisomerase II.

1 reference

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2 September 2018

The DNA demethylating 5-azaC induces endoreduplication in cultured Chinese hamster cells.

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Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines

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Continuous Cyclin E expression inhibits progression through endoreduplication cycles in Drosophila.

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Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state.

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Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression

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In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone

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pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine

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High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells

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https://pubmed.ncbi.nlm.nih.gov/19478553

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Taxol induces bcl-2 phosphorylation and death of prostate cancer cells

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https://pubmed.ncbi.nlm.nih.gov/19478553

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Induction of diplochromosomes in mammalian cells by inhibitors of topoisomerase II

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https://pubmed.ncbi.nlm.nih.gov/19478553

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Physiological regulation of eukaryotic topoisomerase II

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https://pubmed.ncbi.nlm.nih.gov/19478553

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Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest

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Identifiers

10.3858/EMM.2009.41.9.073

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

ResearchGate publication ID

0 references

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