(Q37368145)

English

Anticoagulant synergism of heparin and activated protein C in vitro. Role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C

scientific article published on June 1997

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scholarly article

1 reference

Europe PubMed Central

20 August 2017

Anticoagulant synergism of heparin and activated protein C in vitro. Role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C (English)

1 reference

Europe PubMed Central

20 August 2017

anticoagulation

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

drotrecogin alfa

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

J Petäjä

1

1 reference

Europe PubMed Central

20 August 2017

J A Fernández

2

1 reference

Europe PubMed Central

20 August 2017

A Gruber

3

1 reference

Europe PubMed Central

20 August 2017

J H Griffin

4

1 reference

Europe PubMed Central

20 August 2017

language of work or name

0 references

publication date

1 June 1997

1 reference

Europe PubMed Central

20 August 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

20 August 2017

99

1 reference

Europe PubMed Central

20 August 2017

11

1 reference

Europe PubMed Central

20 August 2017

2655-2663

1 reference

Europe PubMed Central

20 August 2017

Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Mutation in blood coagulation factor V associated with resistance to activated protein C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

The mechanism of inactivation of human factor V and human factor Va by activated protein C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

The protein C anticoagulant system: inherited defects as basis for venous thrombosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Studies of the capacity of factor Xa to protect factor Va from inactivation by activated protein C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Deficiency of protein C in congenital thrombotic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Regulation of activated protein C by a new protein. A possible function for bovine protein S.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Mechanism of Inhibition of Activated Protein C by Protein C Inhibitor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

The binding of activated protein C to factors V and Va

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Purification and characterization of plasma protein C inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Bleeding complications associated with cardiopulmonary bypass.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Heparin inhibition of von Willebrand factor-dependent platelet function in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

The protein C anticoagulant pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

6 September 2017

Activation of factor V during intrinsic and extrinsic coagulation. Inhibition by heparin, hirudin and D-Phe-Pro-Arg-Ch2Cl

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

28 September 2017

Thrombin-catalyzed activation of recombinant human factor V.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

28 September 2017

Unfractionated heparin inhibits thrombin-catalysed amplification reactions of coagulation more efficiently than those catalysed by factor Xa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

28 September 2017

Resistance to activated protein C as a basis for venous thrombosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

26 June 2018

Blood coagulation factor Va abnormality associated with resistance to activated protein C in venous thrombophilia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

26 June 2018

Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

26 June 2018

The inhibition of thrombin-dependent positive-feedback reactions is critical to the expression of the anticoagulant effect of heparin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

26 June 2018

Direct detection of activated protein C in blood from human subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

26 June 2018

Interindividual variation in relationships between plasma heparin concentration and the results of five heparin assays.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

2 September 2018

Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor V.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

2 September 2018

The relative importance of thrombin inhibition and factor Xa inhibition to the antithrombotic effects of heparin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508111

2 September 2018

Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of protein C inhibitor activity by histidine-rich glycoprotein and platelet factor 4: role of zinc and calcium ions in the heparin-neutralizing ability of histidine-rich glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticoagulant protein C pathway defective in majority of thrombophilic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of activated protein C during thrombolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition by heparin of thrombin-catalyzed activation of the factor VIII-von Willebrand factor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated protein C resistance caused by Arg506Gln mutation in factor Va

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of arterial reocclusion after thrombolysis with activated protein C. Comparison with heparin in a canine model of coronary artery thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human protein S inhibits prothrombinase complex activity on endothelial cells and platelets via direct interactions with factors Va and Xa

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition by heparin of the human blood coagulation intrinsic pathway factor X activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombosis and embolism in long-term central venous access for parenteral nutrition

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the molecular defect in factor VR506Q

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heparin and low molecular weight heparins inhibit prothrombinase formation but not its activity in plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic events that regulate factor V activity in whole plasma from normal and activated protein C (APC)-resistant individuals during clotting: an insight into the APC-resistance assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of activated protein C/protein S-mediated inactivation of human factor VIII and factor V

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated protein C-catalyzed proteolysis of factor VIIIa alters its interactions within factor Xase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrinolysis, antithrombin III, and protein C in neonates during cardiac operations

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of human coagulation factor V by activated protein C

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction of bovine factor V and factor V-derived peptides with phospholipid vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The factor Xa-catalyzed activation of factor V

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of thrombin-catalyzed reactions in blood coagulation and platelet activation by heparin fractions in the absence of antithrombin III

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of inactivation of membrane-bound factor Va by activated protein C. Protein S modulates factor Xa protection

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The limited importance of factor Xa inhibition to the anticoagulant property of heparin in thromboplastin-activated plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mode of action of heparin in plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic effect of antithrombin III, activated protein C and heparin on the inhibition of the tissue thromboplastin-mediated coagulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of human factor V by factor Xa and thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of factor X and prothrombin in antithrombin-III depleted plasma: the effects of heparin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flow and the inhibition of prothrombinase by antithrombin III and heparin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI119454

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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