(Q37370315)

20 August 2017

Modification of apolipoprotein(a) lysine binding site reduces atherosclerosis in transgenic mice (English)

1 reference

20 August 2017

1 reference

N W Boonmark

1

1 reference

20 August 2017

X J Lou

2

1 reference

20 August 2017

Z J Yang

3

1 reference

20 August 2017

K Schwartz

4

1 reference

20 August 2017

J L Zhang

5

1 reference

20 August 2017

E M Rubin

6

1 reference

20 August 2017

R M Lawn

7

1 reference

20 August 2017

language of work or name

English

0 references

publication date

1 August 1997

1 reference

Journal of Clinical Investigation

20 August 2017

1 reference

20 August 2017

100

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20 August 2017

3

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20 August 2017

558-564

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A quantitative immunoassay for the lysine-binding function of lipoprotein(a). Application to recombinant apo(a) and lipoprotein(a) in plasma

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Evidence that the fibrinogen binding domain of Apo(a) is outside the lysine binding site of kringle IV-10: a study involving naturally occurring lysine binding defective lipoprotein(a) phenotypes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a).

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Expression of human apolipoprotein B and assembly of lipoprotein(a) in transgenic mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Activation of transforming growth factor-beta is inhibited in transgenic apolipoprotein(a) mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

A single point mutation (Trp72-->Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a)

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Identification of two functionally distinct lysine-binding sites in kringle 37 and in kringles 32-36 of human apolipoprotein(a).

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Atherogenesis in transgenic mice with human apolipoprotein B and lipoprotein (a).

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

cDNA sequence of human apolipoprotein(a) is homologous to plasminogen

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

The mysteries of lipoprotein(a)

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Plasmin catalyzes binding of lipoprotein (a) to immobilized fibrinogen and fibrin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Lipoprotein (a). Heterogeneity and biological relevance

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Synergistic interactions between transcription factors control expression of the apolipoprotein AI gene in liver cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Catabolism of lipoprotein(a) in familial hypercholesterolaemic subjects

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Lipoprotein (a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Further characterization of the cellular plasminogen binding site: evidence that plasminogen 2 and lipoprotein a compete for the same site

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

American College of Cardiology 45th Annual Scientific Session, Orlando, Florida, March 24 to 27, 1996.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Feedback mechanism of focal vascular lesion formation in transgenic apolipoprotein(a) mice

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Lys and fibrinogen binding of wild-type (Trp72) and mutant (Arg72) human apo(a) kringle IV-10 expressed in E coli and CHO cells.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Human apolipoprotein A-I prevents atherosclerosis associated with apolipoprotein[a] in transgenic mice

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Antifibrinolytic activity of apolipoprotein(a) in vivo: Human apolipoprotein(a) transgenic mice are resistant to tissue plasminogen activator-mediated thrombolysis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

A potential basis for the thrombotic risks associated with lipoprotein(a).

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Lipoprotein(a), fibrin binding, and plasminogen activation.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Interaction of apolipoprotein(a) with apolipoprotein B-containing lipoproteins.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Atherogenesis in transgenic mice expressing human apolipoprotein(a)

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a)

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Molecular definition of the extreme size polymorphism in apolipoprotein(a).

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

The apolipoprotein(a) kringle IV repeats which differ from the major repeat kringle are present in variably-sized isoforms.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Relation of plasma lipoprotein(a) to infarct artery patency in survivors of myocardial infarction

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508222

Studies on the Lysine-Binding Sites of Human Plasminogen. The Effect of Ligand Structure on the Binding of Lysine Analogs to Plasminogen

2 September 2018

1 reference

12 December 2020

Lp(a): an interloper into the fibrinolytic system?

1 reference

12 December 2020

Lipoprotein(a) impairs generation of plasmin by fibrin-bound tissue-type plasminogen activator. In vitro studies in a plasma milieu

1 reference

12 December 2020

Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-A resolution

1 reference

12 December 2020

Lysine-binding heterogeneity of Lp(a): consequences for fibrin binding and inhibition of plasminogen activation

1 reference

12 December 2020

Occlusive arterial thrombosis in cynomolgus monkeys with varying plasma concentrations of lipoprotein(a)

1 reference

12 December 2020

Comparison of ligand-binding sites of modeled apo[a] kringle-like sequences in human lipoprotein[a]

1 reference

12 December 2020

Proliferation of human smooth muscle cells promoted by lipoprotein(a)

1 reference

12 December 2020

Protein-ligand interactions in the lysine-binding site of plasminogen kringle 4 are different in crystal and solution. Electrostatic interactions studied by site-directed mutagenesis exclude Lys35 as an important acceptor in solution

1 reference

12 December 2020

Cloning, expression, and characterization of human apolipoprotein(a) kringle IV37

1 reference

12 December 2020

Effect of human apoE4 on the clearance of chylomicron-like lipid emulsions and atherogenesis in transgenic mice

1 reference

12 December 2020

Amino acid residues of the kringle-4 and kringle-5 domains of human plasminogen that stabilize their interactions with omega-amino acid ligands

1 reference

12 December 2020

Relative contributions of apolipoprotein(a) and apolipoprotein-B to the development of fatty lesions in the proximal aorta of mice

1 reference

12 December 2020

The serum concentration of active transforming growth factor-beta is severely depressed in advanced atherosclerosis

1 reference

12 December 2020

Hypertriglyceridemia and elevated lipoprotein(a) are risk factors for major coronary events in middle-aged men

1 reference

12 December 2020

Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger. A prospective study

1 reference

12 December 2020

Optimization of immunofluorescence methods by quantitative image analysis

1 reference

12 December 2020

Lipoprotein(a) inhibition of plasminogen activation by tissue-type plasminogen activator

1 reference

12 December 2020

Heterogeneity of human lipoprotein Lp[a]: cytochemical and biochemical studies on the interaction of two Lp[a] species with the LDL receptor

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI119565

1 reference

20 August 2017

1 reference

20 August 2017

1 reference