(Q37376587)

20 August 2017

Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia (English)

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20 August 2017

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S D Mittelman

1

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20 August 2017

Y Y Fu

2

1 reference

20 August 2017

K Rebrin

3

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20 August 2017

G Steil

4

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20 August 2017

R N Bergman

5

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20 August 2017

language of work or name

English

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publication date

1 December 1997

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Journal of Clinical Investigation

20 August 2017

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20 August 2017

100

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20 August 2017

12

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20 August 2017

3121-3130

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Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Insulin regulation of renal glucose metabolism in conscious dogs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Glucokinase and cytosolic phosphoenolpyruvate carboxykinase (GTP) in the human liver. Regulation of gene expression in cultured hepatocytes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Glucagon levels and metabolic effects in fasting man

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Insulin exerts metabolic and growth-promoting effects by a direct action on the liver in vivo: clarification of the functional significance of the portal vascular link between the beta cells of the pancreatic islets and the liver

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Glucagon in portal hypertension

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

In vitro reversal of the fasting state of liver metabolism in the rat. Reevaluation of the roles of insulin and glucose

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

14 September 2017

Hepatic vascular bed.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Glucagon and diabetes: A reappraisal

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Regulation by insulin of gluconeogenesis in isolated rat hepatocytes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Fatty acids are potent modulators of lactate utilization in isolated hepatocytes from fed rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Decreased responsiveness of basal gluconeogenesis to insulin action in hepatocytes isolated from genetically obese (fa/fa) Zucker rats

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Extrapancreatic effect of somatostatin infusion to increase glucose clearance

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Peripheral effects of insulin dominate suppression of fasting hepatic glucose production

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Hepatic glucagon sensitivity and fasting glucose concentration in normal dogs

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Restoration of stable metabolic conditions during islet suppression in dogs.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Analysis of techniques to obtain plasma for measurement of levels of free fatty acids.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Effects of metformin on glucose and glucagon regulated gluconeogenesis in cultured normal and diabetic hepatocytes.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Free Fatty Acid as a Link in the Regulation of Hepatic Glucose Output by Peripheral Insulin

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

The determination of lactate turnover in vivo with 3H- and 14C-labelled lactate. The significance of sites of tracer administration and sampling

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Evaluation of a sensitive and specific radioimmunoassay for pancreatic glucagon in human plasma and its clinical application.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508525

Intrahepatic distribution of portal and hepatic arterial blood flows in anaesthetized cats and dogs and the effects of portal occlusion, raised venous pressure and histamine

2 September 2018

1 reference

12 December 2020

The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog

1 reference

12 December 2020

The relation of insulin to liver metabolism

1 reference

12 December 2020

Effect of peripheral versus portal venous administration of insulin on postprandial hyperglycemia and glucose turnover in alloxan-diabetic dogs

1 reference

12 December 2020

Evidence for a direct effect of insulin on hepatic glucose output

1 reference

12 December 2020

Antagonism Between the Effects of Insulin and Glucagon on the Isolated Liver

1 reference

12 December 2020

Glucagon enhances the direct suppressive effect of insulin on hepatic glucose production in humans

1 reference

12 December 2020

Failure of somatostatin to modify effect of glucagon on carbohydrate metabolism in the dog

1 reference

12 December 2020

A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog

1 reference

12 December 2020

Effects of portal and peripheral venous insulin infusion on glucose production and utilization in depancreatized, conscious dogs

1 reference

12 December 2020

Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects

1 reference

12 December 2020

Studies on the Perfused Rat Liver: I. Effects of Glucagon and Insulin on Glucose Metabolism

1 reference

12 December 2020

Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentration

1 reference

12 December 2020

Differential time course of glucagon's effect on glycogenolysis and gluconeogenesis in the conscious dog

1 reference

12 December 2020

Site of insulin inhibition of cAMP-stimulated glycogenolysis

1 reference

12 December 2020

Effect of intraportal and peripheral insulin on glucose turnover and recycling in diabetic dogs

1 reference

12 December 2020

A moderate decline in specific activity does not lead to an underestimation of hepatic glucose production during a glucose clamp

1 reference

12 December 2020

Assessment of glucose turnover rates in euglycaemic clamp studies using primed-constant [3-3H]-glucose infusion and labelled or unlabelled glucose infusates

1 reference

12 December 2020

Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates

1 reference

12 December 2020

Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs: role of glucagon

1 reference

12 December 2020

Influence of glucagon and 3', 5'-AMP on insulin responsiveness of the perfused rat liver

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI119867

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

9399959

1 reference