(Q37384434)

English

Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy

scientific article published on August 1998

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

multiple sclerosis

0 references

0 references

author name string

M Comabella

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

K Balashov

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

S Issazadeh

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

D Smith

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

H L Weiner

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

S J Khoury

6

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

language of work or name

0 references

publication date

1 August 1998

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

102

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

671-678

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

6 September 2017

Detection of altered T helper 1 and T helper 2 cytokine production by peripheral blood mononuclear cells in patients with multiple sclerosis utilizing intracellular cytokine detection by flow cytometry and surface marker analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

6 September 2017

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

6 September 2017

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

6 September 2017

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

6 September 2017

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

6 September 2017

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

6 September 2017

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

6 September 2017

Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

6 September 2017

Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

6 September 2017

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

6 September 2017

Detecting cytokine production at the single-cell level

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

6 September 2017

Critical Influences of the Cytokine Orchestration on the Outcome of Myelin Antigen‐Specific T‐Cell Autoimmunity in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

14 September 2017

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

14 September 2017

Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

28 September 2017

Exacerbations of multiple sclerosis in patients treated with gamma interferon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

28 September 2017

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

28 September 2017

Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

28 September 2017

Mechanisms of recovery from experimental autoimmune encephalomyelitis: T cell deletion and immune deviation in myelin basic protein T cell receptor transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

26 June 2018

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

26 June 2018

Cytokine flow cytometry: understanding cytokine biology at the single-cell level

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

26 June 2018

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

26 June 2018

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

26 June 2018

Direct in vitro evidence for different susceptibilities to 4-hydroperoxycyclophosphamide of antigen-primed T cells regulating humoral and cell-mediated immune responses to sheep erythrocytes: a possible explanation for the inverse action of cyclopho

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

26 June 2018

The short-term effect of an immunosuppressive treatment on CSF myelin basic protein in chronic progressive multiple sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

26 June 2018

Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

26 June 2018

Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

26 June 2018

Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: Increased interleukin-4 production and associated eosinophilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508928

3 December 2018

Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated serum levels of interleukin-12 in chronic progressive multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of transforming growth factor-beta production by interleukin-12

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclophosphamide: Effect on Experimental Allergic Encephalomyelitis in Lewis Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclophosphamide inhibition of experimental allergic encephalomyelitis and cellular transfer of the disease in Lewis rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative susceptibilities of T cell subsets involved in delayed-type hypersensitivity to sheep red blood cells to the in vitro action of 4-hydroperoxycyclophosphamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of cyclophosphamide on T lymphocytes and T lymphocyte subsets in patients with chronic progressive multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Administration of monthly pulses of cyclophosphamide in multiple sclerosis patients. Delayed recovery of several immune parameters following discontinuation of long-term cyclophosphamide treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4,

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of intracellular cytokines by flow cytometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo effects of glucocorticoids on IgE production

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased transforming growth factor-beta, interleukin-4, and interferon-gamma in multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9710434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI3125

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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