(Q37388865)

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Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina

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29 February 2020

Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina (English)

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29 February 2020

Laura Contreras

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29 February 2020

Jorgina Satrustegui Gil Delgado

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29 February 2020

François Paquet-Durand

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29 February 2020

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Jianhai Du

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29 February 2020

Whitney M Cleghorn

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29 February 2020

Ken Lindsay

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29 February 2020

Austin M Rountree

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29 February 2020

Andrei O Chertov

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29 February 2020

Sally J Turner

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29 February 2020

Ayse Sahaboglu

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29 February 2020

Jonathan Linton

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29 February 2020

Martin Sadilek

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29 February 2020

Ian R Sweet

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29 February 2020

James B Hurley

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29 February 2020

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1 November 2013

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29 February 2020

Journal of Biological Chemistry

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29 February 2020

288

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29 February 2020

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29 February 2020

36129-36140

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29 February 2020

Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans

1 reference

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6 September 2017

Identification and functional expression of the mitochondrial pyruvate carrier

1 reference

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6 September 2017

IsoCor: correcting MS data in isotope labeling experiments.

1 reference

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6 September 2017

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

1 reference

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6 September 2017

Roles of glucose in photoreceptor survival

1 reference

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6 September 2017

Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions

1 reference

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6 September 2017

PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.

1 reference

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6 September 2017

A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene

1 reference

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6 September 2017

Cyclic nucleotide-gated channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Inhibition of N-type calcium channels by activation of GPR35, an orphan receptor, heterologously expressed in rat sympathetic neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors

1 reference

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6 September 2017

Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Impaired mitochondrial pyruvate importation in a patient and a fetus at risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Retinal degeneration mutants in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Phosphodiesterase 5 inhibitors and nitrergic transmission-from zaprinast to sildenafil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Mutation spectrum of the gene encoding the beta subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Autosomal recessive retinitis pigmentosa caused by mutations in the alpha subunit of rod cGMP phosphodiesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

6 September 2017

Development and advantages of serum-free, chemically defined nutrient media for culturing of nerve tissue

1 reference

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14 September 2017

GPR35 as a Novel Therapeutic Target.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

14 September 2017

Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

28 September 2017

Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861660

26 June 2018

Regional Amino Acid Distribution in Relation to Function in Insulin Hypoglycaemia

1 reference

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26 June 2018

Metabolically derived aspartate--elevated extracellular levels in vivo in lodoacetate poisoning

1 reference

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26 June 2018

Pyruvate transport by thermogenic-tissue mitochondria

1 reference

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26 June 2018

Reversible shifts in the Ca2+-dependent release of aspartate and glutamate from hippocampal slices with changing glucose concentrations

1 reference

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26 June 2018

Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948.

1 reference

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26 June 2018

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1 reference

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1 reference

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2 September 2018

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2 September 2018

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1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Potential roles of conserved amino acids in the catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24187136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24187136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/24187136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1074/JBC.M113.507285

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29 February 2020

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29 February 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24187136%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

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