(Q37416147)

20 August 2017

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title

Challenges and opportunities in CNS delivery of therapeutics for neurodegenerative diseases (English)

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20 August 2017

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Thomas M Barchet

1

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20 August 2017

Mansoor M Amiji

series ordinal

2

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20 August 2017

language of work or name

English

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publication date

1 March 2009

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Expert Opinion on Drug Delivery

20 August 2017

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20 August 2017

6

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20 August 2017

3

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20 August 2017

211-225

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Novel targets for CNS gene therapy

20 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Why is the global CNS pharmaceutical market so under-penetrated?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

A review of nanocarrier-based CNS delivery systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Neuroprotection in a rat Parkinson model by GDNF gene therapy using EIAV vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Delivery of peptides and proteins through the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Gene delivery to the spinal cord: comparison between lentiviral, adenoviral, and retroviral vector delivery systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

21 January 2018

Gene therapy in the CNS.

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Toxic proteins in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Alzheimer Disease in the US Population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Therapies for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Growth-factor gene therapy for neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Mixed results for disease-modification strategies for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

RNA knockdown as a potential therapeutic strategy in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Huntington's disease: from pathology and genetics to potential therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Symptomatic treatment of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

The blood-brain barrier: bottleneck in brain drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

The blood-brain barrier/neurovascular unit in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Fine structural localization of a blood-brain barrier to exogenous peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Astrocyte-endothelial interactions at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

A new aspect of the protective functions of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Drug and gene delivery to the brain: the vascular route

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Recent developments in peptide drug delivery to the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Six-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF) in rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Quantification and pharmacokinetics of blood-brain barrier disruption in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

The blood-brain barrier and bilirubin encephalopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Ethanol enhancement of blood-brain barrier permeability to catecholamines in chicks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Morphologic effect of dimethyl sulfoxide on the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Reversal of multidrug resistance phenotype by surfactants: relationship to membrane lipid fluidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

The role of surfactants in the reversal of active transport mediated by multidrug resistance proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Transvascular delivery of small interfering RNA to the central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Molecular Trojan horses for blood-brain barrier drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Functional expression and localization of P-glycoprotein at the blood brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Increased drug delivery to the brain by P-glycoprotein inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

A strategy for delivering peptides into the central nervous system by sequential metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Synthesis and biological evaluations of brain-targeted chemical delivery systems of [Nva2]-TRH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Nasal drug administration: potential for targeted central nervous system delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Prodrugs in nasal drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

The potential of nasal application for delivery to the central brain-a microdialysis study of fluorescein in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Intranasal drug delivery for brain targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Intranasal delivery could be used to administer drugs directly to the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Preliminary brain-targeting studies on intranasal mucoadhesive microemulsions of sumatriptan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Is nose-to-brain transport of drugs in man a reality?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Manipulating neuropeptidergic pathways in humans: a novel approach to neuropharmacology?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

An Effective Absorption Behavior of Insulin for Diabetic Treatment Following Intranasal Delivery Using Porous Spherical Calcium Carbonate in Monkeys and Healthy Human Volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Can nasal drug delivery bypass the blood-brain barrier?: questioning the direct transport theory

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Formulation and physiological factors influencing CNS delivery upon intranasal administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Role of nanotechnology in pharmaceutical product development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Brain drug delivery of small molecules using immunoliposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Antisense gene therapy of brain cancer with an artificial virus gene delivery system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Drug and gene targeting to the brain with molecular Trojan horses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Emulsion-based delivery systems for lipophilic bioactive components.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Intravenous administration to rabbits of non-stealth and stealth doxorubicin-loaded solid lipid nanoparticles at increasing concentrations of stealth agent: pharmacokinetics and distribution of doxorubicin in brain and other tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Brain uptake of thiamine-coated nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Strategies for intranasal delivery of therapeutics for the prevention and treatment of neuroAIDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Estimation of the amyotrophic lateral sclerosis incidence by capture-recapture method in the Limousin region of France.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Recombinant proteins for neurodegenerative diseases: the delivery issue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Liposomes as carriers of cisplatin into the central nervous system--experiments with 9L gliomas in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Tf-lipoplex-mediated NGF gene transfer to the CNS: neuronal protection and recovery in an excitotoxic model of brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Paclitaxel nanoparticles for the potential treatment of brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Etoposide-incorporated tripalmitin nanoparticles with different surface charge: formulation, characterization, radiolabeling, and biodistribution studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

TAT-conjugated nanoparticles for the CNS delivery of anti-HIV drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Effect of nanoparticulate polybutylcyanoacrylate and methylmethacrylate-sulfopropylmethacrylate on the permeability of zidovudine and lamivudine across the in vitro blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Biodistribution of polysorbate 80-coated doxorubicin-loaded [14C]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to glioblastoma-bearing rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Targeting the central nervous system: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Efficient gene delivery targeted to the brain using a transferrin-conjugated polyethyleneglycol-modified polyamidoamine dendrimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

Drug metabolizing enzymes in the brain and cerebral microvessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240902758188

10.1517/17425240902758188

21 January 2018

Identifiers

DOI

1 reference

release_rsdkxzhlevbg7ogcek52yfr2ga

20 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rsdkxzhlevbg7ogcek52yfr2ga

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference