(Q37427549)

English

The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases

scientific article published on May 2013

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scholarly article

1 reference

Europe PubMed Central

20 August 2017

The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases (English)

1 reference

Europe PubMed Central

20 August 2017

1 reference

ChEBI release 2020-05-28

author name string

Krithi Rao-Bindal

1

1 reference

Europe PubMed Central

20 August 2017

Nadezhda V Koshkina

2

1 reference

Europe PubMed Central

20 August 2017

John Stewart

3

1 reference

Europe PubMed Central

20 August 2017

Eugenie S Kleinerman

4

1 reference

Europe PubMed Central

20 August 2017

publication date

1 May 2013

1 reference

Europe PubMed Central

20 August 2017

Current Cancer Drug Targets

1 reference

Europe PubMed Central

20 August 2017

13

1 reference

Europe PubMed Central

20 August 2017

4

1 reference

Europe PubMed Central

20 August 2017

411-422

1 reference

Europe PubMed Central

20 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3878976/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases

1 reference

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23 August 2017

The clinical development of histone deacetylase inhibitors as targeted anticancer drugs

1 reference

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Understanding micrometastatic disease and Anoikis resistance in ewing family of tumors and osteosarcoma

1 reference

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4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells

1 reference

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23 August 2017

The role of Fas/FasL in the metastatic potential of osteosarcoma and targeting this pathway for the treatment of osteosarcoma lung metastases

1 reference

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PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells

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Depsipeptide induces cell death in Hodgkin lymphoma-derived cell lines

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Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells, enhances their metastatic potential, and reduces the effect of aerosol gemcitabine

1 reference

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The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases.

1 reference

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23 August 2017

Fas expression in lung metastasis from osteosarcoma patients

1 reference

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The multiple uses of fluorescent proteins to visualize cancer in vivo

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Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells

1 reference

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23 August 2017

Human pancreatic cancer cells disable function of Fas receptors at several levels in Fas signal transduction pathway

1 reference

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23 August 2017

Apoptosis control by death and decoy receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

23 August 2017

Inhibition of death receptor signals by cellular FLIP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

23 August 2017

c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

14 September 2017

Fas-negative osteosarcoma tumor cells are selected during metastasis to the lungs: the role of the Fas pathway in the metastatic process of osteosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

14 September 2017

Expression of cellular FLICE inhibitory protein, caspase-8, and protease inhibitor-9 in Ewing sarcoma and implications for susceptibility to cytotoxic pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

14 September 2017

Interleukin-12 up-regulates Fas expression in human osteosarcoma and Ewing's sarcoma cells by enhancing its promoter activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

14 September 2017

Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

14 September 2017

Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers

1 reference

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14 September 2017

Aerosol gene therapy with PEI: IL-12 eradicates osteosarcoma lung metastases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

14 September 2017

MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

14 September 2017

Selective expression of FLIP in malignant melanocytic skin lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

28 September 2017

Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

26 June 2018

Intranasal interleukin-12 gene therapy enhanced the activity of ifosfamide against osteosarcoma lung metastases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

2 September 2018

Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

2 September 2018

Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878976

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c-FLIP expression in bladder urothelial carcinomas: its role in resistance to Fas-mediated apoptosis and clinicopathologic correlations

1 reference

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2 September 2018

The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells

1 reference

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Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy

1 reference

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2 September 2018

Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines

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2 September 2018

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein

1 reference

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Eradication of osteosarcoma lung metastases following intranasal interleukin-12 gene therapy using a nonviral polyethylenimine vector

1 reference

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Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells

1 reference

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2 September 2018

The histone deacetylase inhibitor, CBHA, inhibits growth of human neuroblastoma xenografts in vivo, alone and synergistically with all-trans retinoic acid.

1 reference

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Sensitization of human colon cancer cells to TRAIL-mediated apoptosis

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Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells

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based on heuristic

inferred from PubMed ID database lookup

Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/23410027

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2174/1568009611313040005

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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