(Q37444381)

20 August 2017

Glucuronidation and covalent protein binding of benoxaprofen and flunoxaprofen in sandwich-cultured rat and human hepatocytes (English)

1 reference

20 August 2017

1 reference

ChEBI release 2020-05-28

1 reference

ChEBI release 2020-05-28

Jennifer Q Dong

1

1 reference

PMC publication ID

2784705

20 August 2017

Philip C Smith

series ordinal

2

1 reference

20 August 2017

22 September 2009

1 reference

Drug Metabolism and Disposition

20 August 2017

1 reference

20 August 2017

37

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20 August 2017

12

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20 August 2017

2314-2322

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Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Role of benoxaprofen and flunoxaprofen acyl glucuronides in covalent binding to rat plasma and liver proteins in vivo

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Acyl glucuronide reactivity in perspective: biological consequences

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Xenobiotic acyl glucuronides and acyl CoA thioesters as protein-reactive metabolites with the potential to cause idiosyncratic drug reactions

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Covalent binding of zomepirac glucuronide to proteins: evidence for a Schiff base mechanism

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Pharmacology, clinical efficacy, and adverse effects of the nonsteroidal anti-inflammatory agent benoxaprofen

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Xenobiotic lipids: the inclusion of xenobiotic compounds in pathways of lipid biosynthesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Disposition and covalent binding of ibuprofen and its acyl glucuronide in the elderly

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

The acylation of proteins by xenobiotic amphipathic carboxylic acids in cultured rat hepatocytes

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Benoxaprofen, a New Anti-Inflammatory Agent: Particle-Size Effect on Dissolution Rate and Oral Absorption in Humans

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

A novel approach for predicting acyl glucuronide reactivity via Schiff base formation: development of rapidly formed peptide adducts for LC/MS/MS measurements

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Disposition and reactivity of ibuprofen and ibufenac acyl glucuronides in vivo in the rhesus monkey and in vitro with human serum albumin

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Chemically-induced alteration of UDP-glucuronic acid concentration in rat liver

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784705

Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity

2 September 2018

1 reference

12 December 2020

High-performance liquid chromatographic determination of ibuprofen, its metabolites and enantiomers in biological fluids

1 reference

12 December 2020

Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration

1 reference

12 December 2020

Influence of extracellular matrix overlay on phenobarbital-mediated induction of CYP2B1, 2B2, and 3A1 genes in primary adult rat hepatocyte culture

1 reference

12 December 2020

Metabolic inversion of (R)-ibuprofen. Formation of ibuprofenyl-coenzyme A

1 reference

12 December 2020

Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration

1 reference

12 December 2020

Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac

1 reference

12 December 2020

Covalent binding of acidic drugs via reactive intermediates: detection of benoxaprofen and flunoxaprofen protein adducts in biological material

1 reference

12 December 2020

Selective protein adduct formation of diclofenac glucuronide is critically dependent on the rat canalicular conjugate export pump (Mrp2)

1 reference

12 December 2020

Metabolic activation of carboxylic acids

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12 December 2020

Effect of selective phase II enzyme inducers on glucuronidation of benoxaprofen in rats

1 reference

12 December 2020

In vitro covalent binding of nafenopin-CoA to human liver proteins

1 reference

12 December 2020

The metabolism of ibuprofen

1 reference

12 December 2020

Identifiers

DOI

10.1124/DMD.109.028944

1 reference

20 August 2017

1 reference

PMC publication ID

2784705

20 August 2017

PubMed publication ID

19773537

1 reference

PMC publication ID

2784705