(Q37484078)

20 August 2017

A concise, total synthesis of the TMC-95A/B proteasome inhibitors (English)

1 reference

20 August 2017

Brian K Albrecht

1

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20 August 2017

Robert M Williams

series ordinal

2

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20 August 2017

language of work or name

English

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publication date

26 May 2004

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Proceedings of the National Academy of Sciences of the United States of America

20 August 2017

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20 August 2017

101

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20 August 2017

33

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20 August 2017

11949-11954

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Simplified synthetic TMC-95A/B analogues retain the potency of proteasome inhibitory activity

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514414

Proteasome inhibitors: from research tools to drug candidates

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514414

Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514414

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514414

The ubiquitin-proteasome proteolytic pathway

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514414

Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514414

The total synthesis of proteasome inhibitors TMC-95A and TMC-95B: discovery of a new method to generate cis-propenyl amides

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514414

The core structure of TMC-95A is a promising lead for reversible proteasome inhibition

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514414

Total synthesis of the ramoplanin A2 and ramoplanose aglycon

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514414

Stereoselective synthesis of enamides by a Peterson reaction manifold.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514414

Stereocontrolled synthesis of the northern part of potent proteasome inhibitor TMC-95A.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514414

TMC-95A, B, C, and D, novel proteasome inhibitors produced by Apiospora montagnei Sacc. TC 1093. Taxonomy, production, isolation, and biological activities.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514414

The Palladium-Catalyzed Cross-Coupling Reactions of Organotin Reagents with Organic Electrophiles[New Synthetic Methods(58)]

2 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308432101

Syntheses a l'aide de sulfones v(+)- methode de synthese generale de doubles liaisons

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308432101

Über Isonitrosoacetanilide und deren Kondensation zu Isatinen

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308432101

Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308432101

Synthesis of the Functionalized Macrocyclic Core of Proteasome Inhibitors TMC-95A and B This work was supported by grants from the National Institutes of Health (grant CA28824). We thank Dr. George Sukenick and Sylvi Rusli of the MSKCC NMR Core Faci

21 January 2018

1 reference

12 December 2020

Structures of TMC-95A-D: novel proteasome inhibitors from Apiospora montagnei sacc. TC 1093

1 reference

12 December 2020

Efficient synthesis of novel 3-(Het)arylanthranilic acids via a suzuki cross-coupling reaction of 7-iodoisatin with (Het)arylboronic acids in water

1 reference

12 December 2020

A concise formal total synthesis of TMC-95A/B proteasome inhibitors

1 reference

12 December 2020

Total synthesis of TMC-95A

1 reference

12 December 2020

Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling

1 reference

12 December 2020

Total synthesis of (+)-ambruticin

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0308432101

1 reference

20 August 2017

0 references

1 reference

20 August 2017

PubMed publication ID

15163792

1 reference