(Q37511687)

20 August 2017

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title

The accelerator hypothesis: a review of the evidence for insulin resistance as the basis for type I as well as type II diabetes (English)

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20 August 2017

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T J Wilkin

1

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20 August 2017

language of work or name

English

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publication date

9 June 2009

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International Journal of Obesity

20 August 2017

published in

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20 August 2017

volume

33

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20 August 2017

issue

7

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20 August 2017

page(s)

716-726

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Emerging epidemic of type 2 diabetes in youth

20 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Testing the accelerator hypothesis: the relationship between body mass and age at diagnosis of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Increasing body weight predicts the earlier onset of insulin-dependant diabetes in childhood: testing the 'accelerator hypothesis' (2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

The 'accelerator hypothesis': relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 German and Austrian children with type 1 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Higher body weight is associated with earlier onset of Type 1 diabetes in children: confirming the 'Accelerator Hypothesis'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Obesity, Insulin Resistance, β-Cell Autoimmunity, and the Changing Clinical Epidemiology of Childhood Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Type 1 diabetes: recent developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

HL-A antigens and diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Worldwide increase in incidence of Type I diabetes--the analysis of the data on published incidence trends

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

The rise of childhood type 1 diabetes in the 20th century.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Resistin, obesity, and insulin resistance--the emerging role of the adipocyte as an endocrine organ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Insulin resistance--mechanisms, syndromes, and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Inflammation and metabolic disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

An immune origin of type 2 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Beta-cells in type 2 diabetes: a loss of function and mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

The relative contributions of birth weight, weight change, and current weight to insulin resistance in contemporary 5-year-olds: the EarlyBird Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Trends, associations and predictions of insulin resistance in prepubertal children (EarlyBird 29).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Globalization, coca-colonization and the chronic disease epidemic: can the Doomsday scenario be averted?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Early nutrition and diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Autoimmunity: attack, or defence? (The case for a primary lesion theory).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Increased islet antigen presentation leads to type-1 diabetes in mice with autoimmune susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

The accelerator hypothesis and increasing incidence of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Insulin resistance is a risk factor for progression to type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

No evidence for genetically determined alteration in insulin secretion or sensitivity predisposing to type 1 diabetes: a study of identical twins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Coexistence of type 1 and type 2 diabetes mellitus: "double" diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Beta-cell autoantibodies in children with type 2 diabetes mellitus: subgroup or misclassification?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Letter: Weight gain in infancy and subsequent development of diabetes mellitus in childhood

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Infant feeding, early weight gain, and risk of type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

The incidence of type 1 diabetes in the age group 0-39 years has not increased in Antwerp (Belgium) between 1989 and 2000: evidence for earlier disease manifestation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes--indication of an increased environmental pressure?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

The role of insulin resistance in the natural history of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Insulin resistance in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

High frequency of abnormal glucose tolerance in DQA1*0102/DQB1*0602 relatives identified as part of the Diabetes Prevention Trial--Type 1 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Clinical and pathogenic significance of pancreatic-islet-cell antibodies in diabetics treated with oral hypoglycaemic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Diabetic autoimmune markers in children and adolescents with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Autoimmunity to islet proteins in children diagnosed with new-onset diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Braking the accelerator hypothesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes: response to Dabelea et al.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Major increase in Type 1 diabetes: no support for the Accelerator Hypothesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Thiazolidinediones: a new class of antidiabetic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Future intervention trials in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Obesity, increased linear growth, and risk of type 1 diabetes in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Increased Adiposity at Diagnosis in Younger Children With Type 1 Diabetes Does Not Persist

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

Incidence of insulin-dependent diabetes mellitus in age groups over 30 years in Denmark

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Ketosis-onset diabetes in young adults with subsequent non-insulin-dependency, a link between IDDM and NIDDM?

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Declassifying diabetes

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Changing perspectives in diabetes: their impact on its classification

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Is the 'Accelerator Hypothesis' worthy of our attention?

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

To boldly go--or to go too boldly? The accelerator hypothesis revisited

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Pathologic anatomy of the pancreas in juvenile diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Adipocytokines and the metabolic complications of obesity

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Type 1 1/2 diabetes: myth or reality?

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Autoantibodies and the physiological role of immunoglobulins

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Role of insulin resistance in predicting progression to type 1 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Netherlands Kolibrie study group of childhood diabetes

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

The incidence of Type I diabetes has not increased but shifted to a younger age at diagnosis in the 0-34 years group in Sweden 1983-1998

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Spring harvest? Reflections on the rise of type 1 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Autoimmunity and clinical course in children with type 1, type 2, and type 1.5 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

The accelerator hypothesis cannot be tested using the type 2 diabetes gene, TCF7L2

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Major increase in Type 1 diabetes: no support for the accelerator hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

The aetiology of type 1 diabetes: an epidemiological perspective

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Immune intervention with anti-CD3 in diabetes

1 reference

https://api.crossref.org/works/10.1038%2FIJO.2009.97

7 January 2021

Identifiers

DOI

10.1038/IJO.2009.97

1 reference

20 August 2017

1 reference