(Q37517178)

20 August 2017

1 reference

title

Mineralocorticoid receptor activation in obesity hypertension (English)

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20 August 2017

main subject

arterial hypertension

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obesity

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author name string

Miki Nagase

series ordinal

1

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20 August 2017

Toshiro Fujita

series ordinal

2

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20 August 2017

publication date

12 June 2009

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20 August 2017

published in

Hypertension Research

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20 August 2017

volume

32

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20 August 2017

issue

8

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20 August 2017

page(s)

649-657

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Obesity wars: molecular progress confronts an expanding epidemic

20 August 2017

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The role of renin-angiotensin system blockade in the management of hypertension associated with the cardiometabolic syndrome

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Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension

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Salt excess causes left ventricular diastolic dysfunction in rats with metabolic disorder

21 January 2018

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Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats

21 January 2018

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Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

21 January 2018

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Hibernoma development in transgenic mice identifies brown adipose tissue as a novel target of aldosterone action.

21 January 2018

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Alteration of cardiac and renal functions in transgenic mice overexpressing human mineralocorticoid receptor

21 January 2018

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Genome-wide association study identifies eight loci associated with blood pressure

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Visceral adiposity is an independent predictor of incident hypertension in Japanese Americans

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Hypertension and associated metabolic abnormalities--the role of insulin resistance and the sympathoadrenal system

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The metabolic syndrome and chronic kidney disease in U.S. adults

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Dietary sodium intake and subsequent risk of cardiovascular disease in overweight adults

21 January 2018

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Sodium intake affects urinary albumin excretion especially in overweight subjects

21 January 2018

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Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention study

21 January 2018

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Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension.

21 January 2018

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Genome-wide scan for linkage to obesity-associated hypertension in French Canadians.

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

The glucocorticoid receptor gene and its association to metabolic syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

-344C/T Variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in men.

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

The thrifty-genotype hypothesis and its implications for the study of complex genetic disorders in man.

21 January 2018

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Blood pressure control--special role of the kidneys and body fluids

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

Obesity-associated hypertension and kidney disease

21 January 2018

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Factors that influence the risk of hypertension in obese individuals

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications.

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

Weight loss and the renin-angiotensin-aldosterone system

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

Morbid obesity, hypertensive disease and the renin-angiotensin-aldosterone axis

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Human adipocytes secrete mineralocorticoid-releasing factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Plasma aldosterone is independently associated with the metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Association of adrenal steroids with hypertension and the metabolic syndrome in blacks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Prevalence and characteristics of the metabolic syndrome in primary aldosteronism

21 January 2018

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Serum aldosterone and the incidence of hypertension in nonhypertensive persons

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure

21 January 2018

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Increased salt sensitivity secondary to leptin resistance in SHHF rats is mediated by endothelin

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

A novel adipokine CTRP1 stimulates aldosterone production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Aldosterone stimulated differentiation of mouse 3T3-L1 cells into adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

50th anniversary of aldosterone

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2009.86

Aldosterone in chronic kidney and cardiac disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Aldosterone blockade: an emerging strategy for abrogating progressive renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Effectiveness of aldosterone blockade in patients with diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Regression of existing glomerulosclerosis by inhibition of aldosterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

The incidence and implications of aldosterone breakthrough

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Metabolic syndrome and chronic kidney disease in Okinawa, Japan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Aldosterone and glomerular podocyte injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Aldosterone-induced organ damage: plasma aldosterone level and inappropriate salt status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Modulation of human mineralocorticoid receptor function by protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Evolution of hormone-receptor complexity by molecular exploitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

Public health. Provocative study says obesity may reduce U.S. life expectancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Mineralocorticoid and glucocorticoid receptors inhibit UCP expression and function in brown adipocytes.

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Weight and blood pressure. Findings in hypertension screening of 1 million Americans

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Incidence and precursors of hypertension in young adults: the Framingham Offspring Study

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Role of tumor necrosis factor-alpha gene locus in obesity and obesity-associated hypertension in French Canadians

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Obesity-associated hypertension: new insights into mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Aldosterone in obesity.

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Anticortisol action of aldosterone

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Double-blind, placebo-controlled study on the effect of the aldosterone receptor antagonist spironolactone in patients who have persistent proteinuria and are on long-term angiotensin-converting enzyme inhibitor therapy, with or without an angiotens

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Aldosterone breakthrough during therapy with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in proteinuric patients with immunoglobulin A nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Metabolic syndrome and CKD in a general Japanese population: the Hisayama Study

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Overview: increased cardiovascular risk in patients with minor renal dysfunction: an emerging issue with far-reaching consequences

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators

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https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Rho GTPases as modulators of the estrogen receptor transcriptional response

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Small GTP-binding proteins

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.86

7 January 2021

Identifiers

DOI

10.1038/HR.2009.86

1 reference

20 August 2017

1 reference