(Q37528136)

20 August 2017

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title

Novel pharmacological approaches to combat obesity and insulin resistance: targeting skeletal muscle with 'exercise mimetics'. (English)

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20 August 2017

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A L Carey

1

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PubMed ID

19547950

20 August 2017

B A Kingwell

series ordinal

2

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20 August 2017

23 June 2009

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20 August 2017

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20 August 2017

52

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20 August 2017

10

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20 August 2017

2015-2026

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https://scigraph.springernature.com/pub.10.1007/s00125-009-1420-x

20 August 2017

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cites work

Fundamental questions about genes, inactivity, and chronic diseases

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https://api.crossref.org/works/10.1007%2FS00125-009-1420-X

Systematic Review: Comparative Effectiveness and Safety of Oral Medications for Type 2 Diabetes Mellitus

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-009-1420-X

The effects of changes in physical activity on major cardiovascular risk factors, hemodynamics, sympathetic function, and glucose utilization in man: a controlled study of four levels of activity.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-009-1420-X

Prevention of fat-induced insulin resistance by salicylate

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-009-1420-X

The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-009-1420-X

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-009-1420-X

The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-009-1420-X

Green tea extract improves running endurance in mice by stimulating lipid utilization during exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-009-1420-X

Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.

21 January 2018

1 reference

12 December 2020

Skeletal muscle Ca(2+)-independent kinase activity increases during either hypertrophy or running

1 reference

12 December 2020

Can exercise mimetics substitute for exercise?

1 reference

12 December 2020

Muscle fibre stress in response to exercise: synthesis, accumulation and isoform transitions of 70-kDa heat-shock proteins

1 reference

12 December 2020

Effects of the amount and intensity of exercise on plasma lipoproteins

1 reference

12 December 2020

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes.

1 reference

12 December 2020

Signaling mechanisms in skeletal muscle: acute responses and chronic adaptations to exercise

1 reference

12 December 2020

Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice

1 reference

12 December 2020

Exercise, MAPK, and NF-kappaB signaling in skeletal muscle

1 reference

12 December 2020

SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase

1 reference

12 December 2020

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes

1 reference

12 December 2020

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

1 reference

12 December 2020

Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.

1 reference

12 December 2020

Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

1 reference

12 December 2020

cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats

1 reference

12 December 2020

Exercise and physical training in the treatment of diabetes mellitus

1 reference

12 December 2020

Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake

1 reference

12 December 2020

Calorie restriction increases muscle mitochondrial biogenesis in healthy humans

1 reference

12 December 2020

Effects of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle

1 reference

12 December 2020

Rapid exercise-induced changes in PGC-1alpha mRNA and protein in human skeletal muscle

1 reference

12 December 2020

Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome

1 reference

12 December 2020

Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase

1 reference

12 December 2020

The exercise pill--too good to be true?

1 reference

12 December 2020

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

1 reference

12 December 2020

Ca2+ and the sarcoplasmic reticulum

1 reference

12 December 2020

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

1 reference

12 December 2020

Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport.

1 reference

12 December 2020

A central role for JNK in obesity and insulin resistance

1 reference

12 December 2020

Effects of walking and other exercise programs upon blood pressure in normal subjects

1 reference

12 December 2020

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals

1 reference

12 December 2020

Muscle contractile activity increases fatty acid metabolism and transport and FAT/CD36

1 reference

12 December 2020

Endurance training-induced changes in insulin sensitivity and gene expression

1 reference

12 December 2020

When will we treat physical activity as a legitimate medical therapy...even though it does not come in a pill?

1 reference

12 December 2020

Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5'-AMP-activated protein kinase

1 reference

12 December 2020

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

1 reference

12 December 2020

Does caffeine alter muscle carbohydrate and fat metabolism during exercise?

1 reference

12 December 2020

Genetic Variations inPPARDandPPARGC1ADetermine Mitochondrial Function and Change in Aerobic Physical Fitness and Insulin Sensitivity during Lifestyle Intervention

1 reference

12 December 2020

Exercise training, glucose transporters, and glucose transport in rat skeletal muscles

1 reference

12 December 2020

Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway.

1 reference

12 December 2020

Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance

1 reference

12 December 2020

Regulation of muscle fiber type and running endurance by PPARdelta

1 reference

12 December 2020

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.

1 reference

12 December 2020

Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

1 reference

12 December 2020

Low-intensity exercise increases skeletal muscle protein expression of PPARδ and UCP3 in type 2 diabetic patients

1 reference

12 December 2020

Skeletal muscle adaptation to exercise: a century of progress

1 reference

12 December 2020

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

1 reference

12 December 2020

The epidemiology of obesity: the size of the problem

1 reference

12 December 2020

Why insulin sensitizers but not secretagogues should be retained when initiating insulin in type 2 diabetes

1 reference

12 December 2020

AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

1 reference

12 December 2020

Effect of endurance exercise training on Ca2+ calmodulin-dependent protein kinase II expression and signalling in skeletal muscle of humans

1 reference

12 December 2020

Exercise increases serum Hsp72 in humans

1 reference

12 December 2020

Effects of acute exercise and training on insulin action and sensitivity: focus on molecular mechanisms in muscle

1 reference

12 December 2020

AMPK and PPARdelta agonists are exercise mimetics

1 reference

12 December 2020

Clinical and cost effectiveness of surgery for morbid obesity: a systematic review and economic evaluation

1 reference

12 December 2020

Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle

1 reference

12 December 2020

Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta

1 reference

12 December 2020

Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle

1 reference

12 December 2020

Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse

1 reference

12 December 2020

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

1 reference

12 December 2020

The role of exercise and PGC1alpha in inflammation and chronic disease

1 reference

12 December 2020

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

1 reference

12 December 2020

Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance.

1 reference

12 December 2020

Acadesine, an adenosine-regulating agent with the potential for widespread indications

1 reference

12 December 2020

AMPK and the biochemistry of exercise: implications for human health and disease

1 reference

12 December 2020

Therapeutic potential of resveratrol: the in vivo evidence

1 reference

12 December 2020

Evidence for the involvement of CaMKII and AMPK in Ca2+-dependent signaling pathways regulating FA uptake and oxidation in contracting rodent muscle

1 reference

12 December 2020

High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus

1 reference

12 December 2020

Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.

1 reference

12 December 2020

Drug treatments for obesity: orlistat, sibutramine, and rimonabant.

1 reference

12 December 2020

Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity

1 reference

12 December 2020

SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation

1 reference

12 December 2020

Muscle as an endocrine organ: focus on muscle-derived interleukin-6.

1 reference

12 December 2020

Long-term outcome of bariatric surgery: an interim analysis

1 reference

12 December 2020

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

1 reference

12 December 2020

Effect of exercise on protein kinase C activity and localization in human skeletal muscle

1 reference

12 December 2020

Gastric banding or bypass? A systematic review comparing the two most popular bariatric procedures

1 reference

12 December 2020

Lactic acidosis in biguanide-treated diabetics: a review of 330 cases

1 reference

12 December 2020

HSP72 protects against obesity-induced insulin resistance

1 reference

12 December 2020

Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial

1 reference

12 December 2020

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

1 reference

12 December 2020

Physical activity in the treatment of the adulthood overweight and obesity: current evidence and research issues

1 reference

12 December 2020

Exercise: it's the real thing!

1 reference

12 December 2020

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

1 reference

12 December 2020

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

1 reference

12 December 2020

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

1 reference

12 December 2020

Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle.

1 reference

12 December 2020

Calcium induces increases in peroxisome proliferator-activated receptor gamma coactivator-1alpha and mitochondrial biogenesis by a pathway leading to p38 mitogen-activated protein kinase activation

1 reference

12 December 2020

Overexpression of peroxisome proliferator-activated receptor gamma co-activator-1alpha leads to muscle atrophy with depletion of ATP

1 reference

12 December 2020

Obesity, weight loss and bariatric surgery.

1 reference

12 December 2020

Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes

1 reference

12 December 2020

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

1 reference

12 December 2020

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.

1 reference

12 December 2020

10.1007/S00125-009-1420-X

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19547950