(Q37542931)

20 August 2017

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title

Systems pathology--taking molecular pathology into a new dimension (English)

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20 August 2017

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Dana Faratian

1

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20 August 2017

Robert G Clyde

series ordinal

2

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20 August 2017

John W Crawford

series ordinal

3

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20 August 2017

David J Harrison

series ordinal

4

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20 August 2017

language of work or name

English

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publication date

7 July 2009

1 reference

Nature Reviews Clinical Oncology

20 August 2017

1 reference

20 August 2017

6

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20 August 2017

8

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20 August 2017

455-464

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Computational modelling of ErbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity

20 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

The application of systems biology to drug discovery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

31 March 2020

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Metaplastic breast carcinomas are basal-like tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Triple negative tumours: a critical review

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Do 'basal-like' breast cancers really exist?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Molecular portraits of human breast tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Comparative genomic hybridisation arrays: high-throughput tools to determine targeted therapy in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Basal-like breast cancer and the BRCA1 phenotype

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Breast cancer molecular subtypes respond differently to preoperative chemotherapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Predictive markers in breast cancer--the future

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

The genomic landscapes of human breast and colorectal cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Dynamic computational modeling in the search for better breast cancer drug therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Can the pharmaceutical industry reduce attrition rates?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Cell-signalling dynamics in time and space

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Giving Space to Cell Signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Dynamic proteomics of individual cancer cells in response to a drug.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

31 March 2020

Biological robustness

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Highly Optimized Tolerance: Robustness and Design in Complex Systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Standards and ontologies in computational systems biology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Mathematical models of cell cycle regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Computational approaches to the topology, stability and dynamics of metabolic networks.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Network biology: understanding the cell's functional organization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

The role of modelling in identifying drug targets for diseases of the cell cycle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Systems biology and the heart

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Fitting ordinary differential equations to short time course data

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

A comparison of variant theories of intact biochemical systems. I. Enzyme-enzyme interactions and biochemical systems theory.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Metabolic control analysis in drug discovery and disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Models-of-data and models-of-processes in the post-genomic era.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Systems biology by the rules: hybrid intelligent systems for pathway modeling and discovery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

31 March 2020

Gene expression assays

2 references

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

31 March 2020

12 December 2020

Laser capture microdissection of mammalian tissue

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Automated subcellular localization and quantification of protein expression in tissue microarrays.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Mass spectrometry based targeted protein quantification: methods and applications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Intravital imaging of metastatic behavior through a mammary imaging window.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Melanoma cell-derived factors stimulate glycosaminoglycan synthesis by fibroblasts cultured as monolayers and within contracted collagen lattices

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

The scientific value of preoperative studies and how they can be used

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Proliferation and apoptosis as markers of benefit in neoadjuvant endocrine therapy of breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Intraperitoneal therapy for stage III ovarian cancer: a therapy whose time has come!

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Radiation induces different changes in expression profiles of normal rectal tissue compared with rectal carcinoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.102

Technical demonstration of whole genome array comparative genomic hybridization

31 March 2020

1 reference

PubMed

12 December 2020

Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodium-calcium overload

1 reference

PubMed

12 December 2020

Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine

1 reference

PubMed

12 December 2020

10.1038/NRCLINONC.2009.102

Identifiers

DOI

1 reference

20 August 2017

1 reference