(Q37552150)

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Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats

scientific article published on 24 October 2013

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Europe PubMed Central

PMC publication ID

21 August 2017

Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats (English)

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Europe PubMed Central

PMC publication ID

21 August 2017

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5

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3 June 2020

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Yaoming Wang

1

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3 June 2020

Zhen Zhao

2

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3 June 2020

Nienwen Chow

3

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3 June 2020

Padmesh S Rajput

4

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3 June 2020

Patrick D Lyden

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3 June 2020

Berislav V Zlokovic

7

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3 June 2020

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24 October 2013

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21 August 2017

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Europe PubMed Central

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3 June 2020

44

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3 June 2020

12

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3 June 2020

3529-3536

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Europe PubMed Central

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3 June 2020

describes a project that uses

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11 June 2022

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An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Thrombin activity associated with neuronal damage during acute focal ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Cytoprotective protein C pathways and implications for stroke and neurological disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Thrombolytic therapy for acute ischemic stroke beyond three hours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Severe blood-brain barrier disruption and surrounding tissue injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Update of the stroke therapy academic industry roundtable preclinical recommendations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Validation of an acute ischemic stroke model: does diffusion-weighted imaging lesion volume offer a clinically significant improvement in prediction of outcome?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

The cytoprotective protein C pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

1,026 experimental treatments in acute stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Magnetic resonance imaging indexes of therapeutic efficacy of recombinant tissue plasminogen activator treatment of rat at 1 and 4 hours after embolic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

Recommendations for standards regarding preclinical neuroprotective and restorative drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

A rat model of focal embolic cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

23 August 2017

High-density lipoprotein-based therapy reduces the hemorrhagic complications associated with tissue plasminogen activator treatment in experimental stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

6 September 2017

Can molecular and cellular neuroprotection be translated into therapies for patients?: yes, but not the way we tried it before

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

6 September 2017

Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

28 September 2017

Activated protein C prevents glutamate- and thrombin-induced activation of nuclear factor-kappaB in cultured hippocampal neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

25 June 2018

Use of a spectrophotometric hemoglobin assay to objectively quantify intracerebral hemorrhage in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

25 June 2018

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

25 June 2018

Thrombin mediates severe neurovascular injury during ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

Alteplase for ischaemic stroke--much sooner is much better

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

Endothelial protein C receptor is expressed in rat cortical and hippocampal neurons and is necessary for protective effect of activated protein C at glutamate excitotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

Role of matrix metalloproteinases in delayed cortical responses after stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

MR diffusion-weighted imaging and outcome prediction after ischemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

Functional recovery after embolic stroke in rodents by activated protein C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

Infarct volume as a surrogate or auxiliary outcome measure in ischemic stroke clinical trials. The RANTTAS Investigators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

A semiautomated method for measuring brain infarct volume.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

1 September 2018

Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

2 October 2018

Activated protein C reduces the severity of compression-induced spinal cord injury in rats by inhibiting activation of leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3912991

2 October 2018

Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24159062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebral hemorrhage: effects of aging on brain edema and neurological deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/24159062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena

1 reference

https://pubmed.ncbi.nlm.nih.gov/24159062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancing the Development and Approval of Acute Stroke Therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24159062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NXY-059 for the treatment of acute ischemic stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/24159062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

National US Estimates of Recombinant Tissue Plasminogen Activator Use

1 reference

https://pubmed.ncbi.nlm.nih.gov/24159062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of activated protein C on neonatal hypoxic ischemic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/24159062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/STROKEAHA.113.003350

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159062%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159062%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24159062%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

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