(Q37565374)

21 August 2017

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title

Titin-based mechanical signalling in normal and failing myocardium (English)

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21 August 2017

Martina Krüger

1

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21 August 2017

Wolfgang A Linke

series ordinal

2

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21 August 2017

publication date

1 April 2009

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Journal of Molecular and Cellular Cardiology

21 August 2017

published in

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21 August 2017

volume

46

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21 August 2017

issue

4

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21 August 2017

page(s)

490-498

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The giant protein titin: a major player in myocardial mechanics, signaling, and disease

21 August 2017

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Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts

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Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure

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7 January 2021

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7 January 2021

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7 January 2021

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The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly

7 January 2021

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The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins

7 January 2021

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7 January 2021

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7 January 2021

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Obscurin is a ligand for small ankyrin 1 in skeletal muscle

7 January 2021

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Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Molecular interactions with obscurin are involved in the localization of muscle-specific small ankyrin1 isoforms to subcompartments of the sarcoplasmic reticulum

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Mapping the binding site on small ankyrin 1 for obscurin

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Calpain 1 binding capacities of the N1-line region of titin are significantly enhanced by physiological concentrations of calcium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Actin removal from cardiac myocytes shows that near Z line titin attaches to actin while under tension

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice

7 January 2021

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Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2

7 January 2021

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DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis

7 January 2021

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Ischemia-induced association of the stress protein alpha B-crystallin with I-band portion of cardiac titin

7 January 2021

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Association of the chaperone alphaB-crystallin with titin in heart muscle.

7 January 2021

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Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy

7 January 2021

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The Muscle Ankyrin Repeat Proteins: CARP, ankrd2/Arpp and DARP as a Family of Titin Filament-based Stress Response Molecules

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

The Ankrd2 Protein, a Link Between the Sarcomere and the Nucleus in Skeletal Muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Possible functions of p94 in connectin-mediated signaling pathways in skeletal muscle cells

7 January 2021

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Calpain 3: a key regulator of the sarcomere?

7 January 2021

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Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain

7 January 2021

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Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

7 January 2021

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Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin

7 January 2021

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Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.

7 January 2021

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Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Structural basis for activation of the titin kinase domain during myofibrillogenesis

7 January 2021

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M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

The kinase domain of titin controls muscle gene expression and protein turnover

7 January 2021

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Mechanically induced titin kinase activation studied by force-probe molecular dynamics simulations

7 January 2021

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Mechanoenzymatics of titin kinase

7 January 2021

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Targeted homozygous deletion of M-band titin in cardiomyocytes prevents sarcomere formation

7 January 2021

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Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region

7 January 2021

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7 January 2021

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7 January 2021

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Titin mutations as the molecular basis for dilated cardiomyopathy

7 January 2021

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Structural analysis of the titin gene in hypertrophic cardiomyopathy: identification of a novel disease gene

7 January 2021

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Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.

7 January 2021

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Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy

7 January 2021

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Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy.

7 January 2021

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C-terminal titin deletions cause a novel early-onset myopathy with fatal cardiomyopathy

7 January 2021

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Truncating mutations in C-terminal titin may cause more severe tibial muscular dystrophy (TMD).

7 January 2021

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Titinopathies and extension of the M-line mutation phenotype beyond distal myopathy and LGMD2J.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

Tibial muscular dystrophy in a Belgian family

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.01.004

10.1016/J.YJMCC.2009.01.004

7 January 2021

Identifiers

DOI

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21 August 2017

1 reference