(Q37600403)

English

Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4.

scientific article published on May 1996

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4. (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

A D Vaz

1

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

S J Pernecky

2

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

G M Raner

3

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

M J Coon

4

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

language of work or name

0 references

publication date

1 May 1996

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

93

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

4644-4648

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Structure of cytochrome P450eryF involved in erythromycin biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

23 August 2017

The role of Thr268 in oxygen activation of cytochrome P450BM-3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

23 August 2017

Mechanistic studies on C-19 demethylation in oestrogen biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

23 August 2017

High-resolution crystal structure of cytochrome P450cam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

23 August 2017

Primary structures of multiple forms of cytochrome P-450 isozyme 2 derived from rabbit pulmonary and hepatic cDNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

23 August 2017

Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

23 August 2017

Catalysis by cytochrome P-450 of an oxidative reaction in xenobiotic aldehyde metabolism: deformylation with olefin formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

23 August 2017

Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

23 August 2017

Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

23 August 2017

Purification and properties of a shortened form of cytochrome P-450 2E1: deletion of the NH2-terminal membrane-insertion signal peptide does not alter the catalytic activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

23 August 2017

Role of Thr-252 in cytochrome P450cam: a study with unnatural amino acid mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

6 September 2017

Subcellular localization, aggregation state, and catalytic activity of microsomal P450 cytochromes modified in the NH2-terminal region and expressed in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

6 September 2017

Mechanism and inhibition of cytochrome P-450 aromatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

6 September 2017

Kinetics of reduction of cytochrome P-450LM4 in a reconstituted liver microsomal enzyme system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

14 September 2017

Properties of NADPH-cytochrome P-450 reductase purified from rabbit liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

14 September 2017

Oxygen activation by cytochrome P-450.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

14 September 2017

Hydrogen peroxide-supported oxidation of NG-hydroxy-L-arginine by nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

28 September 2017

On the mechanism of action of cytochrome P450: evaluation of hydrogen abstraction in oxygen-dependent alcohol oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

25 June 2018

Secondary structure prediction of 52 membrane-bound cytochromes P450 shows a strong structural similarity to P450cam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

25 June 2018

Androgen formation by cytochrome P450 CYP17. Solvent isotope effect and pL studies suggest a role for protons in the regulation of oxene versus peroxide chemistry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

1 September 2018

Structure and function of cytochromes P450: a comparative analysis of three crystal structures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

1 September 2018

Alcohol-inducible cytochrome P-450IIE1 lacking the hydrophobic NH2-terminal segment retains catalytic activity and is membrane-bound when expressed in Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39332

1 September 2018

Solvent effects on reversible formation and oxidative stability of heme-oxygen complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two forms of liver microsomal cytochrome P-450, P-450lm2 and P-450LM4 (rabbit liver)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide in hepatic microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of cytochrome P-450, NADPH-cytochrome P-450 reductase, phospholipid, and substrate in the reconstituted liver microsomal enzyme system

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological strategies for the manipulation of dioxygen. The chemistry of cytochrome P-450

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the membrane topology of vertebrate cytochrome P-450 proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of threonine-301 from cytochromes P-450 (laurate (omega-1)-hydroxylase and testosterone 16 alpha-hydroxylase) in substrate binding as demonstrated by site-directed mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (omega-1)-hydroxylase and testosterone 16 alpha-hydroxylase)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed mutageneses of rat liver cytochrome P-450d: catalytic activities toward benzphetamine and 7-ethoxycoumarin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity of 6-deoxyerythronolide B hydroxylase, a bacterial cytochrome P450 of erythromycin A biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoaffinity labeling of cytochrome P450 2B4: capture of active site heme ligands by a photocarbene

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential roles of Glu318 and Thr319 in cytochrome P450 1A2 catalysis supported by NADPH-cytochrome P450 reductase and tert-butyl hydroperoxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aromatization of a bicyclic steroid analog, 3-oxodecalin-4-ene-10-carboxaldehyde, by liver microsomal cytochrome P450 2B4

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8643457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.93.10.4644

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

1996PNAS...93.4644V

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

ResearchGate publication ID

0 references

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