(Q37620379)

21 August 2017

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title

Epithelial-mesenchymal transition in development and cancer (English)

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21 August 2017

Douglas S Micalizzi

1

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21 August 2017

Heide L Ford

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

1 October 2009

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21 August 2017

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21 August 2017

volume

5

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21 August 2017

issue

8

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21 August 2017

page(s)

1129-1143

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Conserved patterns of cell movements during vertebrate gastrulation

21 August 2017

cites work

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Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart

21 January 2018

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Transforming growth factor beta (TGFbeta) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT).

21 January 2018

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Neural crest cells: a model for invasive behavior

21 January 2018

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Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development

21 January 2018

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Epithelial-mesenchymal transition and its implications for fibrosis

21 January 2018

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Epithelial-mesenchymal transitions in tumour progression

21 January 2018

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Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines

21 January 2018

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Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

21 January 2018

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The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling

21 January 2018

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Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney

21 January 2018

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Transforming growth factor-beta in cancer and metastasis

21 January 2018

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Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin

21 January 2018

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Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

21 January 2018

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Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

21 January 2018

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Of mice, frogs and flies: generation of membrane asymmetries in early development

21 January 2018

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The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it

21 January 2018

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RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulation

21 January 2018

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Slug is an essential target of TGFbeta2 signaling in the developing chicken heart.

21 January 2018

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The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition

21 January 2018

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The role of twist during palate development.

21 January 2018

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TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development

21 January 2018

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Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

21 January 2018

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Transitions between epithelial and mesenchymal states in development and disease

21 January 2018

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Snail family members and cell survival in physiological and pathological cleft palates

21 January 2018

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Transforming growth factor beta in cardiovascular development and function

21 January 2018

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Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes.

21 January 2018

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The role of epithelial-mesenchymal transition in cancer pathology

21 January 2018

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Epithelial-mesenchymal transition and the invasive potential of tumors.

21 January 2018

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21 January 2018

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Thrombospondin-1 is a major activator of TGF-beta1 in vivo

21 January 2018

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Smad transcription factors

21 January 2018

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Role of transforming growth factor beta in human disease

21 January 2018

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Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice

21 January 2018

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Signaling via the Tgf-beta type I receptor Alk5 in heart development

21 January 2018

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TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

21 January 2018

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TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

21 January 2018

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TGF-beta and epithelial-to-mesenchymal transitions

21 January 2018

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Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

21 January 2018

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Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.

21 January 2018

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Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

21 January 2018

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The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

21 January 2018

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MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA

21 January 2018

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Small non-coding RNAs in animal development

21 January 2018

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

21 January 2018

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TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

21 January 2018

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Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

21 January 2018

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Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

21 January 2018

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In vivo and in vitro evidence for transforming growth factor-beta1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma.

21 January 2018

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Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion

21 January 2018

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Inflammatory cytokines augments TGF-beta1-induced epithelial-mesenchymal transition in A549 cells by up-regulating TbetaR-I.

21 January 2018

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VEGF, FGF2, TGFB1 and TGFBR1 mRNA expression levels correlate with the malignant transformation of the uterine cervix.

21 January 2018

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Expression of TGF-beta isoforms, TGF-beta receptors, and SMAD molecules at different stages of human glioma.

21 January 2018

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TGF-beta1 genotype and phenotype in breast cancer and their associations with IGFs and patient survival

21 January 2018

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Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

21 January 2018

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Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

21 January 2018

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Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast

21 January 2018

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Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse

21 January 2018

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Convergence of Wnt, beta-catenin, and cadherin pathways

21 January 2018

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Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK

21 January 2018

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The Wnt/Wg signal transducer beta-catenin controls fibronectin expression

21 January 2018

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Molecular requirements for epithelial-mesenchymal transition during tumor progression

21 January 2018

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Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT.

21 January 2018

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A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells

21 January 2018

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Prognostic and diagnostic significance of beta-catenin nuclear immunostaining in colorectal cancer

21 January 2018

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The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

21 January 2018

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Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest

21 January 2018

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The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

21 January 2018

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Snail-associated epithelial-mesenchymal transition promotes oesophageal squamous cell carcinoma motility and progression.

21 January 2018

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The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha

21 January 2018

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Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level

21 January 2018

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Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition

21 January 2018

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The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition

21 January 2018

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Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor

21 January 2018

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Connexin43 repression following epithelium-to-mesenchyme transition in embryonal carcinoma cells requires Snail1 transcription factor.

21 January 2018

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The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors

21 January 2018

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Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha.

21 January 2018

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MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer

21 January 2018

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Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

21 January 2018

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Expression of the zinc-finger transcription factor Snail in adrenocortical carcinoma is associated with decreased survival

21 January 2018

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Slug is overexpressed in gastric carcinomas and may act synergistically with SIP1 and Snail in the down-regulation of E-cadherin.

21 January 2018

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Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients

21 January 2018

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Snail silencing effectively suppresses tumour growth and invasiveness.

21 January 2018

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The transcriptional repressor Snail promotes mammary tumor recurrence

21 January 2018

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Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer

21 January 2018

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Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

21 January 2018

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Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism

21 January 2018

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TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development.

21 January 2018

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Direct regulation of TWIST by HIF-1alpha promotes metastasis

21 January 2018

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Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression

21 January 2018

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TWIST modulates prostate cancer cell-mediated bone cell activity and is upregulated by osteogenic induction

21 January 2018

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The expression of Twist has an impact on survival in human bladder cancer and is influenced by the smoking status.

21 January 2018

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Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis

21 January 2018

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Altered myogenesis in Six1-deficient mice

21 January 2018

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Six1 is required for the early organogenesis of mammalian kidney

21 January 2018

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Genes that control the development of migrating muscle precursor cells.

21 January 2018

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Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development.

21 January 2018

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Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

21 January 2018

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Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition

21 January 2018

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Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis

21 January 2018

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Gene amplification is a mechanism of Six1 overexpression in breast cancer

21 January 2018

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Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival.

21 January 2018

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Substantial changes in gene expression of Wnt, MAPK and TNFalpha pathways induced by TGF-beta1 in cervical cancer cell lines

21 January 2018

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Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FON.09.94

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21 August 2017

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