(Q37622124)

21 August 2017

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title

Structural basis of activation of cys-loop receptors: the extracellular-transmembrane interface as a coupling region (English)

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21 August 2017

main subject

transmembrane protein

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author name string

Mariana Bartos

series ordinal

1

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21 August 2017

Jeremías Corradi

series ordinal

2

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21 August 2017

Cecilia Bouzat

series ordinal

3

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21 August 2017

publication date

28 October 2009

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21 August 2017

published in

Molecular Neurobiology

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21 August 2017

volume

40

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21 August 2017

issue

3

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21 August 2017

page(s)

236-252

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https://api.crossref.org/works/10.1007%2FS12035-009-8084-X

21 August 2017

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Nicotinic receptors, allosteric proteins and medicine.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12035-009-8084-X

Mutation causing severe myasthenia reveals functional asymmetry of AChR signature cystine loops in agonist binding and gating.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12035-009-8084-X

Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors.

21 January 2018

1 reference

12 December 2020

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1 reference

12 December 2020

Detection and trapping of intermediate states priming nicotinic receptor channel opening

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12 December 2020

Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence

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12 December 2020

Crosslinking of proteins in acetylcholine receptor-rich membranes: association between the beta-subunit and the 43 kd subsynaptic protein

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12 December 2020

An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors

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12 December 2020

Mammalian nicotinic acetylcholine receptors: from structure to function

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12 December 2020

Structural basis of the different gating kinetics of fetal and adult acetylcholine receptors

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12 December 2020

Prediction of 5-HT3 receptor agonist-binding residues using homology modeling.

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12 December 2020

Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors

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12 December 2020

Nicotinic receptor interloop proline anchors beta1-beta2 and Cys loops in coupling agonist binding to channel gating

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12 December 2020

An intersubunit trigger of channel gating in the muscle nicotinic receptor.

1 reference

12 December 2020

Subunit-selective contribution to channel gating of the M4 domain of the nicotinic receptor

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12 December 2020

Opened by a twist: a gating mechanism for the nicotinic acetylcholine receptor

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12 December 2020

Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening

1 reference

12 December 2020

Mapping the lipid-exposed regions in the Torpedo californica nicotinic acetylcholine receptor

1 reference

12 December 2020

Energy and structure of the M2 helix in acetylcholine receptor-channel gating.

1 reference

12 December 2020

Acetylcholine receptor gating at extracellular transmembrane domain interface: the "pre-M1" linker

1 reference

12 December 2020

Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel.

1 reference

12 December 2020

Structural mechanisms underlying benzodiazepine modulation of the GABA(A) receptor

1 reference

12 December 2020

Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer

1 reference

12 December 2020

Coupling of agonist binding to channel gating in the GABA(A) receptor

1 reference

12 December 2020

Isomerization of the proline in the M2-M3 linker is not required for activation of the human 5-HT3A receptor.

1 reference

12 December 2020

Nicotine binding to brain receptors requires a strong cation-pi interaction

1 reference

12 December 2020

Molecular, pharmacological and functional diversity of 5-HT receptors

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12 December 2020

Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors

1 reference

12 December 2020

Analysis of GLRA1 in hereditary and sporadic hyperekplexia: a novel mutation in a family cosegregating for hyperekplexia and spastic paraparesis

1 reference

12 December 2020

Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens

1 reference

12 December 2020

A glia-derived acetylcholine-binding protein that modulates synaptic transmission.

1 reference

12 December 2020

Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors

1 reference

12 December 2020

Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles

1 reference

12 December 2020

Channel opening motion of alpha7 nicotinic acetylcholine receptor as suggested by normal mode analysis

1 reference

12 December 2020

Establishing an ion pair interaction in the homomeric rho1 gamma-aminobutyric acid type A receptor that contributes to the gating pathway.

1 reference

12 December 2020

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor

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12 December 2020

A study of curare action with an electrical micromethod

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12 December 2020

N-glycosylation sites on the nicotinic ACh receptor subunits regulate receptor channel desensitization and conductance

1 reference

12 December 2020

A hydrophobic gate in an ion channel: the closed state of the nicotinic acetylcholine receptor

1 reference

12 December 2020

The Ligand Gated Ion Channel database: an example of a sequence database in neuroscience

1 reference

12 December 2020

Mutations at lipid-exposed residues of the acetylcholine receptor affect its gating kinetics

1 reference

12 December 2020

The nicotinic receptor ligand binding domain

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12 December 2020

Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution

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12 December 2020

Single-channel currents recorded from membrane of denervated frog muscle fibres

1 reference

12 December 2020

Gating dynamics of the acetylcholine receptor extracellular domain.

1 reference

12 December 2020

A nomenclature for ligand-gated ion channels

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12 December 2020

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.

1 reference

12 December 2020

Muscle and neuronal nicotinic acetylcholine receptors. Structure, function and pathogenicity.

1 reference

12 December 2020

Rapid upregulation of alpha7 nicotinic acetylcholine receptors by tyrosine dephosphorylation.

1 reference

12 December 2020

Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels

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12 December 2020

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

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12 December 2020

Contributions of the non-alpha subunit residues (loop D) to agonist binding and channel gating in the muscle nicotinic acetylcholine receptor

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12 December 2020

Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.

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12 December 2020

The 5-HT3B subunit is a major determinant of serotonin-receptor function

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12 December 2020

Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions

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12 December 2020

Single-channel kinetic analysis of chimeric alpha7-5HT3A receptors.

1 reference

12 December 2020

Phosphorylation of the alpha4 subunit of human alpha4beta2 nicotinic receptors: role of cAMP-dependent protein kinase (PKA) and protein kinase C (PKC).

1 reference

12 December 2020

Key roles of hydrophobic rings of TM2 in gating of the alpha9alpha10 nicotinic cholinergic receptor

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12 December 2020

Charged residues in the alpha1 and beta2 pre-M1 regions involved in GABAA receptor activation.

1 reference

12 December 2020

The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function.

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12 December 2020

The role of the cystine loop in acetylcholine receptor assembly

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12 December 2020

Barriers to ion translocation in cationic and anionic receptors from the Cys-loop family

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12 December 2020

The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans

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12 December 2020

Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

1 reference

12 December 2020

Recent advances in Cys-loop receptor structure and function

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12 December 2020

Single-channel kinetic analysis for activation and desensitization of homomeric 5-HT(3)A receptors

1 reference

12 December 2020

Recent advances in understanding the structure of nicotinic acetylcholine receptors

1 reference

12 December 2020

Allosteric proteins after thirty years: the binding and state functions of the neuronal alpha 7 nicotinic acetylcholine receptors

1 reference

12 December 2020

Neuronal nicotinic receptors in non-neuronal cells: new mediators of tobacco toxicity?

1 reference

12 December 2020

Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome

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12 December 2020

Structure and gating mechanism of the acetylcholine receptor pore

1 reference

12 December 2020

Evolutionary relationship of the ligand-gated ion channels and the avermectin-sensitive, glutamate-gated chloride channels.

1 reference

12 December 2020

The submembrane machinery for nicotinic acetylcholine receptor clustering

1 reference

12 December 2020

Regulation of nicotinic acetylcholine receptors by tyrosine kinases in the peripheral and central nervous system: same players, different roles.

1 reference

12 December 2020

A study of desensitization of acetylcholine receptors using nerve-released transmitter in the frog

1 reference

12 December 2020

Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model.

1 reference

12 December 2020

Functional properties of a cloned 5-hydroxytryptamine ionotropic receptor subunit: comparison with native mouse receptors

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12 December 2020

Regulation of the neuronal nicotinic acetylcholine receptor by SRC family tyrosine kinases

1 reference

12 December 2020

Asymmetric contribution of the conserved disulfide loop to subunit oligomerization and assembly of the nicotinic acetylcholine receptor.

1 reference

12 December 2020

Bubbles, gating, and anesthetics in ion channels

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12 December 2020

The extracellular linker of muscle acetylcholine receptor channels is a gating control element

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12 December 2020

Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans

1 reference

12 December 2020

Phosphorylation of the nicotinic acetylcholine receptor by protein tyrosine kinases

1 reference

12 December 2020

Regulation of alpha4beta2 nicotinic receptor desensitization by calcium and protein kinase C.

1 reference

12 December 2020

Nanosecond-timescale conformational dynamics of the human alpha7 nicotinic acetylcholine receptor

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12 December 2020

Threonine in the selectivity filter of the acetylcholine receptor channel

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12 December 2020

Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E

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12 December 2020

Gating mechanisms in Cys-loop receptors

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12 December 2020

Anxiety over GABA(A) receptor structure relieved by AChBP.

1 reference

12 December 2020

Molecular basis of the differential sensitivity of nematode and mammalian muscle to the anthelmintic agent levamisole.

1 reference

12 December 2020

Number and locations of agonist binding sites required to activate homomeric Cys-loop receptors

1 reference

12 December 2020

3B but which 3B and that's just one of the questions: the heterogeneity of human 5-HT3 receptors.

1 reference

12 December 2020

Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells

1 reference

12 December 2020

A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptor

1 reference

12 December 2020

The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit

1 reference

12 December 2020

The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization

1 reference

12 December 2020

Principal pathway coupling agonist binding to channel gating in nicotinic receptors

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12 December 2020

Role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors

1 reference

12 December 2020

Molecular tuning of fast gating in pentameric ligand-gated ion channels

1 reference

12 December 2020

Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E.

1 reference

12 December 2020

Activation of GABA(A) receptors containing the alpha4 subunit by GABA and pentobarbital

1 reference

12 December 2020

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

1 reference

12 December 2020

A cytoplasmic region determines single-channel conductance in 5-HT3 receptors

1 reference

12 December 2020

Toxin insights into nicotinic acetylcholine receptors

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12 December 2020

Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.

1 reference

12 December 2020

The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptors

1 reference

12 December 2020

Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein

1 reference

12 December 2020

A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors

1 reference

12 December 2020

A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics

1 reference

12 December 2020

A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors.

1 reference

12 December 2020

Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function.

1 reference

12 December 2020

Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor

1 reference

12 December 2020

Precise localization of alpha7 nicotinic acetylcholine receptors on glutamatergic axon terminals in the rat ventral tegmental area.

1 reference

12 December 2020

Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization

1 reference

12 December 2020

Agonist-induced conformational changes in the extracellular domain of alpha 7 nicotinic acetylcholine receptors

1 reference

12 December 2020

Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events

1 reference

12 December 2020

Phi-value analysis of a linear, sequential reaction mechanism: theory and application to ion channel gating

1 reference

12 December 2020

Molecular determinants of pyrantel selectivity in nicotinic receptors

1 reference

12 December 2020

Desensitization of nicotinic ACh receptors: shaping cholinergic signaling

1 reference

12 December 2020

Agonist-activated ion channels

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12 December 2020

Human vascular endothelial cells express functional nicotinic acetylcholine receptors

1 reference

12 December 2020

Allosteric mechanisms of signal transduction

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12 December 2020

Mechanics of channel gating of the nicotinic acetylcholine receptor

1 reference

12 December 2020

GABA A receptors: subtypes provide diversity of function and pharmacology

1 reference

12 December 2020

The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences

1 reference

12 December 2020

Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors

1 reference

12 December 2020

Unliganded gating of acetylcholine receptor channels

1 reference

12 December 2020

Opening rate of acetylcholine receptor channels

1 reference

12 December 2020

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

1 reference

12 December 2020

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

1 reference

12 December 2020

Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism

1 reference

12 December 2020

Probing ion-channel pores one proton at a time

1 reference

12 December 2020

Identifying the lipid-protein interface of the Torpedo nicotinic acetylcholine receptor: secondary structure implications

1 reference

12 December 2020

Pore conformations and gating mechanism of a Cys-loop receptor

1 reference

12 December 2020

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

1 reference

12 December 2020

The non-neuronal cholinergic system in humans: expression, function and pathophysiology

1 reference

12 December 2020

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

1 reference

12 December 2020

Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor.

1 reference

12 December 2020

Mutational analysis of familial and sporadic hyperekplexia

1 reference

12 December 2020

Mechanisms of neurosteroid interactions with GABA(A) receptors.

1 reference

12 December 2020

A family of acetylcholine-gated chloride channel subunits in Caenorhabditis elegans

1 reference

12 December 2020

Cys-loop receptors: new twists and turns

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12 December 2020

Synaptogenesis: The MAP location of GABA receptors

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12 December 2020

A stepwise mechanism for acetylcholine receptor channel gating

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12 December 2020

The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms

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12 December 2020

Structural dynamics of the M4 transmembrane segment during acetylcholine receptor gating

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12 December 2020

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

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12 December 2020

A conserved salt bridge critical for GABA(A) receptor function and loop C dynamics

1 reference

12 December 2020

The dynamics of the rapsyn scaffolding protein at individual acetylcholine receptor clusters.

1 reference

12 December 2020

Rapsyn variants in ciliary ganglia and their possible effects on clustering of nicotinic receptors

1 reference

12 December 2020

Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist

1 reference

12 December 2020

Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye.

1 reference

12 December 2020

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

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12 December 2020

Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism

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12 December 2020

Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor

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12 December 2020

Rapsyn clusters neuronal acetylcholine receptors but is inessential for formation of an interneuronal cholinergic synapse

1 reference

12 December 2020

Effect of 5-hydroxyindole on ethanol potentiation of 5-hydroxytryptamine (5-HT)3 receptor-activated ion current in NCB-20 neuroblastoma cells

1 reference

12 December 2020

Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors

1 reference

12 December 2020

Cation-pi interactions involving aromatic amino acids

1 reference

12 December 2020

Ligand-gated chloride channels are receptors for biogenic amines in C. elegans

1 reference

12 December 2020

Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker

1 reference

12 December 2020

Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel

1 reference

12 December 2020

A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors.

1 reference

12 December 2020

Relationship between alpha 7 nAChR and apoptosis in human lymphocytes.

1 reference

12 December 2020

Single-channel current through nicotinic receptor produced by closure of binding site C-loop

1 reference

12 December 2020

Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics

1 reference

12 December 2020

On the nature of partial agonism in the nicotinic receptor superfamily

1 reference

12 December 2020

Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the alphaM2-cap

1 reference

12 December 2020

Nicotinic receptor fourth transmembrane domain: hydrogen bonding by conserved threonine contributes to channel gating kinetics

1 reference

12 December 2020

Trans-cis switching mechanisms in proline analogues and their relevance for the gating of the 5-HT3 receptor.

1 reference

12 December 2020

A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists.

1 reference

12 December 2020

EXP-1 is an excitatory GABA-gated cation channel

1 reference

12 December 2020

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

1 reference

12 December 2020

Arginine 222 in the pre-transmembrane domain 1 of 5-HT3A receptors links agonist binding to channel gating

1 reference

12 December 2020

Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel

1 reference

12 December 2020

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

1 reference

12 December 2020

How to turn the reaction coordinate into time

1 reference

12 December 2020

Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants

1 reference

12 December 2020

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

1 reference

12 December 2020

An energy-efficient gating mechanism in the acetylcholine receptor channel suggested by molecular and Brownian dynamics

1 reference

12 December 2020

The quantitative analysis of drug-receptor interactions: a short history

1 reference

12 December 2020

Roles for loop 2 residues of alpha1 glycine receptors in agonist activation.

1 reference

12 December 2020

10.1007/S12035-009-8084-X

Identifiers

DOI

1 reference

21 August 2017

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