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PDE5 inhibitors: in vitro and in vivo pharmacological profile.

scientific article published on January 2009

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11 February 2020

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PDE5 inhibitors: in vitro and in vivo pharmacological profile (English)

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Chrysanthi Sardeli

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D Kouvelas

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A Goulas

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G Papazisis

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C Pourzitaki

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Current Pharmaceutical Design

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11 February 2020

Cyclic GMP phosphodiesterase-5: target of sildenafil

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https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats.

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

The efficacy and safety of udenafil, a new selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Cerebral haemodynamic response or excitability is not affected by sildenafil

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https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

The mineralocorticoid receptor in endothelial physiology and disease: novel concepts in the understanding of erectile dysfunction.

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Non-invasive diagnostic tools for investigating endothelial dysfunction

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Role of sildenafil in neurological disorders

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Effects of phosphodiesterase-5 inhibition by sildenafil in the pressure overloaded right heart.

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytes

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro.

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Role of nitric oxide in the physiology of erection

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Central effects of sildenafil (Viagra) on auditory selective attention and verbal recognition memory in humans: a study with event-related brain potentials

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Sildenafil inhibits hypoxia-induced pulmonary hypertension

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Human PDE5A gene encodes three PDE5 isoforms from two alternate promoters

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Tonic-clonic seizures in patients taking sildenafil

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

The phosphodiesterase 5 inhibitor sildenafil has no effect on cerebral blood flow or blood velocity, but nevertheless induces headache in healthy subjects

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Zaprinast, a phosphodiesterase 5 inhibitor, overcomes sexual dysfunction produced by fluoxetine, a selective serotonin reuptake inhibitor in hamsters

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

DA-8159, a new PDE5 inhibitor, attenuates the development of compensatory right ventricular hypertrophy in a rat model of pulmonary hypertension

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Vardenafil (Levitra) for erectile dysfunction: a systematic review and meta-analysis of clinical trial reports.

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Phosphodiesterase inhibition by sildenafil citrate attenuates the learning impairment induced by blockade of cholinergic muscarinic receptors in rats

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Hemiballism due to sildenafil use.

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis.

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Aggressive behavior increases after termination of chronic sildenafil treatment in mice

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Transient global amnesia after intake of tadalafil, a PDE-5 inhibitor: a possible association?

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

A double blind, randomised study of sildenafil citrate for erectile dysfunction in men with multiple sclerosis

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Activation of the PI3-K/Akt pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Analysis of the mechanism underlying the peripheral antinociceptive action of sildenafil in the formalin test

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Life after PDE4: overcoming adverse events with dual-specificity phosphodiesterase inhibitors

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

PDE5 inhibitors and permanent visual loss

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Tadalafil improves quality of life and exercise tolerance in idiopathic pulmonary arterial hypertension

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Phosphodiesterase inhibition by sildenafil citrate attenuates a maze learning impairment in rats induced by nitric oxide synthase inhibition

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Indirect comparison of interventions using published randomised trials: systematic review of PDE-5 inhibitors for erectile dysfunction

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway.

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Efficacy of sildenafil citrate (Viagra) in men with premature ejaculation

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

The proconvulsant effect of sildenafil in mice: role of nitric oxide-cGMP pathway

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Endosomal hyperacidification in cystic fibrosis is due to defective nitric oxide-cylic GMP signalling cascade

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Long-term vardenafil therapy improves hemodynamics in patients with pulmonary hypertension.

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Selective blockade of phosphodiesterase types 2, 5 and 9 results in cyclic 3'5' guanosine monophosphate accumulation in retinal pigment epithelium cells

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Effects of gender, age, diabetes mellitus and renal and hepatic impairment on tadalafil pharmacokinetics

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

The role of pharmacokinetics and pharmacodynamics in phosphodiesterase-5 inhibitor therapy.

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Neurorestorative treatment of stroke: cell and pharmacological approaches

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Normal sexual response in women

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Expression of the PDE5 enzyme on human retinal tissue: new aspects of PDE5 inhibitors ocular side effects.

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Erectile dysfunction drugs and risk of anterior ischaemic optic neuropathy: casual or causal association?

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Sildenafil (Viagra) evokes retinal arteriolar dilation: dual pathways via NOS activation and phosphodiesterase inhibition

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Essential role of mitochondrial Ca2+-activated and ATP-sensitive K+ channels in sildenafil-induced late cardioprotection.

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Sildenafil inhibits duodenal contractility via activation of the NO-K+ channel pathway

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Safety, tolerability and pharmacokinetics of udenafil, a novel PDE-5 inhibitor, in healthy young Korean subjects

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets

1 reference

https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

Phosphodiesterase isozymes involved in regulation of formula secretion in isolated mouse stomach in vitro

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https://www.researchgate.net/publication/38039938_PDE5_Inhibitors_In_Vitro_and_In_Vivo_Pharmacological_Profile#references

(PDF) PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile (English)

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