(Q37628444)

21 August 2017

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title

The increase in renin during renin inhibition: does it result in harmful effects by the (pro)renin receptor? (English)

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21 August 2017

A H Jan Danser

1

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21 August 2017

publication date

6 November 2009

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21 August 2017

published in

Hypertension Research

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21 August 2017

volume

33

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21 August 2017

issue

1

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21 August 2017

page(s)

4-10

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https://scigraph.springernature.com/pub.10.1038/hr.2009.186

21 August 2017

exact match

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cites work

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade prevent cardiac remodeling in pigs after myocardial infarction: role of tissue angiotensin II

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https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Intrarenal angiotensin II: interstitial and cellular levels and site of production

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https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells.

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Prorenin Induces Intracellular Signaling in Cardiomyocytes Independently of Angiotensin II

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Integrating drug pharmacokinetics for phenotyping individual renin response to angiotensin II blockade in humans

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https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Aliskiren combined with losartan in type 2 diabetes and nephropathy

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https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial

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https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy

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https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Prorenin-induced myocyte proliferation: no role for intracellular angiotensin II.

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Aliskiren-binding increases the half life of renin and prorenin in rat aortic vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Aliskiren accumulates in Renin secretory granules and binds plasma prorenin

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Renin, prorenin and the putative (pro)renin receptor

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Conformational changes in prorenin during renin inhibition in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Newly developed renin and prorenin assays and the clinical evaluation of renin inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Determinants of interindividual variation of renin and prorenin concentrations: evidence for a sexual dimorphism of (pro)renin levels in humans

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https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

The renin rise with aliskiren: it's simply stoichiometry

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https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Aliskiren fails to lower blood pressure in patients who have either low PRA levels or whose PRA falls insufficiently or reactively rises

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Aliskiren monotherapy results in the greatest and the least blood pressure lowering in patients with high- and low-baseline PRA levels, respectively

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Plasma renin and the antihypertensive effect of the orally active renin inhibitor aliskiren in clinical hypertension

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Local renin-angiotensin systems: the unanswered questions

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https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Cultured neonatal rat cardiac myocytes and fibroblasts do not synthesize renin or angiotensinogen: evidence for stretch-induced cardiomyocyte hypertrophy independent of angiotensin II.

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Transendothelial transport of renin-angiotensin system components

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Renin-angiotensin system components in the interstitial fluid of the isolated perfused rat heart. Local production of angiotensin I

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Uptake and proteolytic activation of prorenin by cultured human endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension.

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats.

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Circulating versus tissue renin-angiotensin system: on the origin of (pro)renin

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

(Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

The (Pro)renin receptor: site-specific and functional linkage to the vacuolar H+-ATPase in the kidney.

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Long-term regulation of vacuolar H(+)-ATPase by angiotensin II in proximal tubule cells.

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

(Pro)renin receptor and vacuolar H+-ATPase

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Elevated blood pressure and heart rate in human renin receptor transgenic rats.

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Renal (pro)renin receptor upregulation in diabetic rats through enhanced angiotensin AT1 receptor and NADPH oxidase activity

1 reference

https://api.crossref.org/works/10.1038%2FHR.2009.186

7 January 2021

Identifiers

DOI

10.1038/HR.2009.186

1 reference

21 August 2017

1 reference