(Q37636163)

21 August 2017

1 reference

title

Ruboxistaurin: PKC-beta inhibition for complications of diabetes (English)

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21 August 2017

Ronald P Danis

1

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21 August 2017

Matthew J Sheetz

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

1 December 2009

1 reference

Expert Opinion on Pharmacotherapy

21 August 2017

published in

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21 August 2017

volume

10

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21 August 2017

issue

17

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21 August 2017

page(s)

2913-2925

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

21 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy

21 January 2018

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

21 January 2018

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The RAGE axis in early diabetic retinopathy

21 January 2018

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The role of protein kinase C activation and the vascular complications of diabetes

21 January 2018

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Protein kinase C activation and the development of diabetic complications

21 January 2018

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The Role of Advanced Glycation End Products in Retinal Microvascular Leukostasis

21 January 2018

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Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats

21 January 2018

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Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes

21 January 2018

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21 January 2018

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21 January 2018

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Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412.

21 January 2018

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(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta

21 January 2018

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Advanced glycosylation end products stimulate collagen mRNA synthesis in mesangial cells mediated by protein kinase C and transforming growth factor-beta

21 January 2018

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Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress.

21 January 2018

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The extended protein kinase C superfamily

21 January 2018

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Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

21 January 2018

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Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII.

21 January 2018

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Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth

21 January 2018

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Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation

21 January 2018

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The potential role of PKC beta in diabetic retinopathy and macular edema

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Protein kinase C-beta as a therapeutic target in breast cancer.

21 January 2018

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Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes

21 January 2018

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Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus

21 January 2018

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High concentration of glucose inhibits glomerular endothelial eNOS through a PKC mechanism

21 January 2018

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Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans

21 January 2018

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Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation

21 January 2018

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Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy

21 January 2018

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Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients

21 January 2018

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A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase C-beta inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy

21 January 2018

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Effects of protein kinase Cbeta inhibition on neurovascular dysfunction in diabetic rats: interaction with oxidative stress and essential fatty acid dysmetabolism

21 January 2018

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Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation

21 January 2018

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Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy

21 January 2018

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Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina

21 January 2018

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Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition

21 January 2018

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Production of extracellular matrix by glomerular epithelial cells is regulated by transforming growth factor-beta 1.

21 January 2018

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Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.

21 January 2018

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Protein kinase C phosphorylates caldesmon77 and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

21 January 2018

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Sural sensory action potential identifies diabetic peripheral neuropathy responders to therapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656560903401620

Endothelial and neural regulation of skin microvascular blood flow in patients with diabetic peripheral neuropathy: effect of treatment with the isoform-specific protein kinase C beta inhibitor, ruboxistaurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656560903401620

Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial

21 January 2018

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https://api.crossref.org/works/10.1517%2F14656560903401620

Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656560903401620

The effect of ruboxistaurin on nephropathy in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656560903401620

The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656560903401620

Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656560903401620

Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656560903401620

Effect of ruboxistaurin on the visual acuity decline associated with long-standing diabetic macular edema

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656560903401620

Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656560903401620

Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656560903401620

Factors That Impact Symptomatic Diabetic Peripheral Neuropathy in Placebo-Administered Patients From Two 1-Year Clinical Trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656560903401620

10.1517/14656560903401620

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference