(Q37636343)

21 August 2017

Emulating multicentre clinical stroke trials: a new paradigm for studying novel interventions in experimental models of stroke (English)

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multicenter clinical trial

21 August 2017

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author name string

P M W Bath

series ordinal

1

1 reference

PubMed ID

19930059

21 August 2017

M R Macleod

series ordinal

2

1 reference

PubMed ID

19930059

21 August 2017

A R Green

series ordinal

3

1 reference

21 August 2017

1 December 2009

1 reference

International Journal of Stroke

21 August 2017

1 reference

21 August 2017

4

1 reference

21 August 2017

471-479

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21 August 2017

6

1 reference

Calcium antagonists for ischemic stroke: a systematic review

21 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Controlled safety study of a hemoglobin-based oxygen carrier, DCLHb, in acute ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Selfotel in acute ischemic stroke : possible neurotoxic effects of an NMDA antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Use of anti-ICAM-1 therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Comparison of treatment effects between animal experiments and clinical trials: systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Why do all drugs work in animals but none in stroke patients? 2. Neuroprotective therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Animal models of stroke: do they have value for discovering neuroprotective agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Pharmacological approaches to acute ischaemic stroke: reperfusion certainly, neuroprotection possibly

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Use of animal models has not contributed to development of acute stroke therapies: pro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Use of animal models has not contributed to development of acute stroke therapies: con.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Stroke drug development: usually, but not always, animal models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Recommendations for standards regarding preclinical neuroprotective and restorative drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: a need for more rigorous testing of neuroprotective agents in animal models of stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

How can we improve the pre-clinical development of drugs for stroke?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Effects of NXY-059 in experimental stroke: an individual animal meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Identifying low-quality preclinical studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Quality of full and final publications reporting acute stroke trials: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Influence of age on stroke and preconditioning-induced ischemic tolerance in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Update of the stroke therapy academic industry roundtable preclinical recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Coadministration of NXY-059 and tenecteplase six hours following embolic strokes in rabbits improves clinical rating scores

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

NXY-059: a neuroprotective agent in acute stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Experimental models, neurovascular mechanisms and translational issues in stroke research

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Systematic reviews as a tool for planning and interpreting trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Sample size calculations in acute stroke trials: a systematic review of their reporting, characteristics, and relationship with outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Generation of allocation sequences in randomised trials: chance, not choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Glyceryl trinitrate vs. control, and continuing vs. stopping temporarily prior antihypertensive therapy, in acute stroke: rationale and design of the Efficacy of Nitric Oxide in Stroke (ENOS) trial (ISRCTN99414122).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Comparison of stratification and adaptive methods for treatment allocation in an acute stroke clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Systematic reviews in health care: Assessing the quality of controlled clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Allocation concealment in randomised trials: defending against deciphering

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

The NeuroGrid stroke exemplar clinical trial protocol

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

A systematic review of nitric oxide donors and L-arginine in experimental stroke; effects on infarct size and cerebral blood flow.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Pooling of animal experimental data reveals influence of study design and publication bias

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Bias in meta-analysis detected by a simple, graphical test

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

A comparison of methods to detect publication bias in meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

The Virtual International Stroke Trials Archive.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Individual patient data meta-analysis of randomized controlled trials of community occupational therapy for stroke patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Dipyridamole for preventing recurrent ischemic stroke and other vascular events: a meta-analysis of individual patient data from randomized controlled trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

Can We Improve the Statistical Analysis of Stroke Trials?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-4949.2009.00386.X

10.1111/J.1747-4949.2009.00386.X

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19930059