(Q37650398)

English

Darapladib

scientific article published on January 2010

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scholarly article

1 reference

Europe PubMed Central

21 August 2017

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Europe PubMed Central

Darapladib (English)

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Europe PubMed Central

21 August 2017

author name string

Quang T Bui

1

1 reference

Europe PubMed Central

21 August 2017

Robert L Wilensky

2

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Europe PubMed Central

21 August 2017

language of work or name

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publication date

1 January 2010

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Europe PubMed Central

21 August 2017

Expert Opinion on Investigational Drugs

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Europe PubMed Central

21 August 2017

19

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Europe PubMed Central

21 August 2017

1

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Europe PubMed Central

21 August 2017

161-168

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Europe PubMed Central

21 August 2017

Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

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Intensive versus moderate lipid lowering with statins after acute coronary syndromes

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MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial

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One-year cardiovascular event rates in outpatients with atherothrombosis.

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Inflammation, atherosclerosis, and coronary artery disease

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The molecular basis of vulnerable plaque: potential therapeutic role for immunomodulation

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Lipid signalling in disease.

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Lp-PLA2: a new kid on the block

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Future role for selective phospholipase A2 inhibitors in the prevention of atherosclerotic cardiovascular disease

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Anti-inflammatory properties of a platelet-activating factor acetylhydrolase

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The expanding superfamily of phospholipase A(2) enzymes: classification and characterization

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New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease

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Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo

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Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position

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Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta

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Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident coronary heart disease in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study

1 reference

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Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam Study

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Lipoprotein-associated phospholipase A2: an independent predictor of coronary artery disease events in primary and secondary prevention

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Role of lipoprotein-associated phospholipase A2 in atherosclerosis: biology, epidemiology, and possible therapeutic target

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Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells

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Activation of ICAM-1 promoter by lysophosphatidylcholine: possible involvement of protein tyrosine kinases

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Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes

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Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor

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21 January 2018

Lipoprotein-associated phospholipase A2: a potential new risk factor for coronary artery disease and a therapeutic target

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beta-very low density lipoprotein enhances inducible nitric oxide synthase expression in cytokine-stimulated vascular smooth muscle cells

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Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages.

1 reference

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Site-specific atherogenic gene expression correlates with subsequent variable lesion development in coronary and peripheral vasculature

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Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

1 reference

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Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase

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Functional impairment of two novel mutations detected in lipoprotein-associated phospholipase A2 (Lp-PLA2) deficiency patients

1 reference

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A mutation in plasma platelet-activating factor acetylhydrolase (Val279-->Phe) is a genetic risk factor for stroke

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Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men.

1 reference

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Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese

1 reference

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Prediction of the risk of myocardial infarction from polymorphisms in candidate genes

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The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.

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The phospholipase A2 superfamily and its group numbering system

1 reference

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The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk equivalent: the results of a multicenter, randomized, dou

1 reference

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Effects of the direct lipoprotein-associated phospholipase A(2) inhibitor darapladib on human coronary atherosclerotic plaque

1 reference

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AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update

1 reference

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21 January 2018

Identifiers

10.1517/13543780903501513

1 reference

Europe PubMed Central

21 August 2017

1 reference

Europe PubMed Central

21 August 2017

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