(Q37653253)

English

Folding of the RNA recognition motif (RRM) domains of the amyotrophic lateral sclerosis (ALS)-linked protein TDP-43 reveals an intermediate state

scientific article published on 04 February 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Folding of the RNA recognition motif (RRM) domains of the amyotrophic lateral sclerosis (ALS)-linked protein TDP-43 reveals an intermediate state (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

amyotrophic lateral sclerosis

0 references

protein folding

0 references

RNA recognition motif domain

1 reference

based on heuristic

inferred from title

author name string

Brian C Mackness

1

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Meme T Tran

2

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Shannan P McClain

3

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

C Robert Matthews

4

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Jill A Zitzewitz

5

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

language of work or name

0 references

publication date

4 February 2014

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

289

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

8264-8276

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Genetics of amyotrophic lateral sclerosis: an update.

1 reference

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23 August 2017

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders

1 reference

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23 August 2017

RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43.

1 reference

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23 August 2017

Inhibition of TDP-43 aggregation by nucleic acid binding

1 reference

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23 August 2017

Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Controversies and priorities in amyotrophic lateral sclerosis

1 reference

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23 August 2017

Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates

1 reference

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23 August 2017

TARDBP mutations in Parkinson's disease

1 reference

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23 August 2017

The RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic acid binding site.

1 reference

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23 August 2017

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

1 reference

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23 August 2017

Does a loss of TDP-43 function cause neurodegeneration?

1 reference

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23 August 2017

TDP-43: a new player on the AD field?

1 reference

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23 August 2017

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

1 reference

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23 August 2017

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

TDP-43 regulates its mRNA levels through a negative feedback loop

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Quantitative approaches to monitor protein-nucleic acid interactions using fluorescent probes

1 reference

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23 August 2017

A series of PDB related databases for everyday needs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

TAR DNA-binding protein 43 in neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Structural insights into TDP-43 in nucleic-acid binding and domain interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

1 reference

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23 August 2017

Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 Concept

1 reference

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23 August 2017

Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

RNA recognition motifs: boring? Not quite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Using circular dichroism spectra to estimate protein secondary structure

1 reference

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23 August 2017

Mapping the structure of folding cores in TIM barrel proteins by hydrogen exchange mass spectrometry: the roles of motif and sequence for the indole-3-glycerol phosphate synthase from Sulfolobus solfataricus

1 reference

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23 August 2017

Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

A tightly packed hydrophobic cluster directs the formation of an off-pathway sub-millisecond folding intermediate in the alpha subunit of tryptophan synthase, a TIM barrel protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

1 reference

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Analysis and prediction of leucine-rich nuclear export signals

1 reference

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Domain architectures and characterization of an RNA-binding protein, TLS

1 reference

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23 August 2017

Protein aggregation and neurodegenerative disease

1 reference

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23 August 2017

Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9

1 reference

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23 August 2017

Sequence complexity of disordered protein

1 reference

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23 August 2017

Automated analysis of interatomic contacts in proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

23 August 2017

Folding mechanism of the alpha-subunit of tryptophan synthase, an alpha/beta barrel protein: global analysis highlights the interconversion of multiple native, intermediate, and unfolded forms through parallel channels

1 reference

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23 August 2017

Temperature, stability, and the hydrophobic interaction

1 reference

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23 August 2017

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

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23 August 2017

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

1 reference

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Determination and analysis of urea and guanidine hydrochloride denaturation curves

1 reference

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23 August 2017

Temperature dependence of the hydrophobic interaction in protein folding

1 reference

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23 August 2017

Calculation of protein extinction coefficients from amino acid sequence data

1 reference

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23 August 2017

RRM-RNA recognition: NMR or crystallography…and new findings

1 reference

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6 September 2017

Molecular properties of TAR DNA binding protein-43 fragments are dependent upon its cleavage site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

6 September 2017

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961654

14 September 2017

Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.

1 reference

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14 September 2017

Structural determinants of the cellular localization and shuttling of TDP-43.

1 reference

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14 September 2017

Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.

1 reference

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14 September 2017

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1 reference

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25 June 2018

RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.

1 reference

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1 September 2018

Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation.

1 reference

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1 September 2018

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1 reference

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1 September 2018

Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.

1 reference

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1 September 2018

Induction of amyloid fibrils by the C-terminal fragments of TDP-43 in amyotrophic lateral sclerosis

1 reference

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1 September 2018

Kinetic traps in the folding of beta alpha-repeat proteins: CheY initially misfolds before accessing the native conformation

1 reference

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1 September 2018

Large-scale purification of a stable form of recombinant tobacco etch virus protease

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1 September 2018

Structural properties and RNA-binding activities of two RNA recognition motifs of a mouse neural RNA-binding protein, mouse-Musashi-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542779

21 January 2018

An RBD that does not bind RNA: NMR secondary structure determination and biochemical properties of the C-terminal RNA binding domain from the human U1A protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/24497641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.542779

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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