(Q37666225)

21 August 2017

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title

Transgenic mouse models of mitochondrial toxicity associated with HIV/AIDS and antiretrovirals (English)

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21 August 2017

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anti-retroviral agent

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Christopher Koczor

1

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21 August 2017

James Kohler

series ordinal

2

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21 August 2017

William Lewis

series ordinal

3

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21 August 2017

language of work or name

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4 January 2010

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21 August 2017

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21 August 2017

volume

51

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21 August 2017

issue

4

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21 August 2017

page(s)

399-404

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Frequency of myocarditis, left ventricular dysfunction and ventricular tachycardia in the acquired immune deficiency syndrome

21 August 2017

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1 reference

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Cardiomyopathy Associated with Antiretroviral Therapy in Patients with HIV Infection: A Report of Six Cases

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Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine

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Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine

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Batteries not included: diagnosis and management of mitochondrial disease.

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Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS.

7 January 2021

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Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease

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Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance.

7 January 2021

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Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals

7 January 2021

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Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma

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Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation

7 January 2021

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Modifying Human Thymidylate Kinase to Potentiate Azidothymidine Activation

7 January 2021

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Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP

7 January 2021

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7 January 2021

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Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis

7 January 2021

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DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations.

7 January 2021

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Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis

7 January 2021

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Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma.

7 January 2021

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Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation

7 January 2021

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Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis

7 January 2021

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

7 January 2021

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

7 January 2021

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Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

7 January 2021

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Tat protein of human immunodeficiency virus type 1 represses expression of manganese superoxide dismutase in HeLa cells

7 January 2021

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HIV-1 protein Vpr causes gross mitochondrial dysfunction in the yeast Saccharomyces cerevisiae

7 January 2021

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Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes

7 January 2021

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Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression

7 January 2021

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The trans-activator gene of the human T cell lymphotropic virus type III is required for replication

7 January 2021

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7 January 2021

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The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation

7 January 2021

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7 January 2021

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7 January 2021

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Dilated cardiomyopathy in transgenic mice expressing HIV Tat.

7 January 2021

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Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1

7 January 2021

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The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore

7 January 2021

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HIV viral protein R causes atrial cardiomyocyte mitosis, mesenchymal tumor, dysrhythmia, and heart failure.

7 January 2021

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Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

7 January 2021

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Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

7 January 2021

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Transgenic mitochondrial superoxide dismutase and mitochondrially targeted catalase prevent antiretroviral-induced oxidative stress and cardiomyopathy.

7 January 2021

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Extension of murine life span by overexpression of catalase targeted to mitochondria

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress

7 January 2021

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Focal glomerulosclerosis in proviral and c-fms transgenic mice links Vpr expression to HIV-associated nephropathy

7 January 2021

1 reference

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HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis

7 January 2021

1 reference

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HIV-1 Tat inhibits neprilysin and elevates amyloid beta

7 January 2021

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Tenofovir renal toxicity targets mitochondria of renal proximal tubules

7 January 2021

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10.1016/J.YMETH.2009.12.013

7 January 2021

Identifiers

DOI

1 reference

21 August 2017

1 reference