(Q37682095)

22 August 2017

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title

Cell regulation by sphingosine and more complex sphingolipids (English)

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22 August 2017

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Merrill AH Jr

1

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22 August 2017

publication date

1 February 1991

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Journal of Bioenergetics and Biomembranes

22 August 2017

published in

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22 August 2017

volume

23

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22 August 2017

issue

1

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22 August 2017

page(s)

83-104

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Gangliosides as bimodal regulators of cell growth

22 August 2017

cites work

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12 December 2020

Dexamethasone increases neutral sphingomyelinase activity and sphingosine levels in 3T3-L1 fibroblasts

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12 December 2020

Phospholipid functional groups involved in protein kinase C activation, phorbol ester binding, and binding to mixed micelles.

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12 December 2020

Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia

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12 December 2020

Tumor-promoter-resistant cells lack trisialoganglioside response

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12 December 2020

Biphasic response of Na+-dependent amino acid transport to tumor promoting phorbol esters in cultured renal epithelial cells, LLC-PK1

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12 December 2020

Alteration of glycolipids in ras-transfected NIH 3T3 cells

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12 December 2020

Mitogenesis of 3T3 fibroblasts induced by endogenous ganglioside is not mediated by cAMP, protein kinase C, or phosphoinositides turnover

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12 December 2020

Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst

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12 December 2020

Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils

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12 December 2020

1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells

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12 December 2020

Intracellular calcium release mediated by sphingosine derivatives generated in cells

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12 December 2020

Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells

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12 December 2020

The subcellular localization of neutral sphingomyelinase in rat liver

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12 December 2020

Modified ganglioside as a possible modulator of transmembrane signaling mechanism through growth factor receptors: a preliminary note

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12 December 2020

Regulation of protein kinase C activity by gangliosides

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12 December 2020

Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes.

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12 December 2020

Activation of the epidermal growth factor receptor tyrosine protein kinase in the absence of receptor oligomerization

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12 December 2020

Protein kinase C regulation by sphingosine/lysosphingolipids

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12 December 2020

Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways

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12 December 2020

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

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12 December 2020

Mechanism of protein kinase C inhibition by sphingosine

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12 December 2020

Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for an involvement of protein kinase C.

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12 December 2020

Sphingosine inhibits calmodulin-dependent enzymes

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12 December 2020

Incorporation and metabolism of ganglioside GM2 in skin fibroblasts from normal and GM2 gangliosidosis subjects.

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12 December 2020

Incorporation of exogenous glycosphingolipids in plasma membranes of cultured hamster cells and concurrent change of growth behavior

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12 December 2020

Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor

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12 December 2020

Sialidase activities of cultured human fibroblasts and the metabolism of GM3 ganglioside

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12 December 2020

Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors

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12 December 2020

Dexamethasone influences the lipid fluidity, lipid composition and glycosphingolipid glycosyltransferase activities of rat proximal-small-intestinal Golgi membranes

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12 December 2020

ATP stimulates the hydrolysis of phosphatidylethanolamine in NIH 3T3 cells. Potentiating effects of guanosine triphosphates and sphingosine

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12 December 2020

Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation

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12 December 2020

Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release

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12 December 2020

Ganglioside-modulated protein phosphorylation in muscle. Activation of phosphorylase b kinase by gangliosides

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12 December 2020

Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles

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12 December 2020

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor

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12 December 2020

Free sphingosines in porcine epidermis

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12 December 2020

Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases

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12 December 2020

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds

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12 December 2020

Prevention of the TPA-mediated down-regulation of protein kinase C

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12 December 2020

Direct evidence that endogenous GM1 ganglioside can mediate thymocyte proliferation

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12 December 2020

Free sphingosine formation from endogenous substrates by a liver plasma membrane system with a divalent cation dependence and a neutral pH optimum

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12 December 2020

A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth.

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12 December 2020

Effect of retinoic acid and phorbol-12-myristate-13-acetate on glycosyltransferase activities in normal and transformed cells

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12 December 2020

Inhibition of protein kinase C-dependent cellular proliferation by interaction of endogenous ganglioside GM1 with the B subunit of cholera toxin.

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12 December 2020

Regulation of protein kinase C activity by lipids

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12 December 2020

Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose

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12 December 2020

Enzymatic synthesis of N,N-dimethyl-sphingosine: demonstration of the sphingosine: N-methyltransferase in mouse brain

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12 December 2020

Protein kinase C enhances Ca2+ mobilization in human platelets by activating Na+/H+ exchange

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12 December 2020

Inhibition of Na,K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid.

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12 December 2020

GM3 ganglioside induces hamster fibrobiast growth inhibition in chemically-defined medium: Ganglioside may regulate growth factor receptor function

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12 December 2020

Regulation of platelet protein kinase C by oleic acid. Kinetic analysis of allosteric regulation and effects on autophosphorylation, phorbol ester binding, and susceptibility to inhibition

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12 December 2020

Thrombin-induced changes of intracellular [Ca2+] and pH in human platelets. Cytoplasmic alkalinization is not a prerequisite for calcium mobilization

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12 December 2020

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway

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12 December 2020

A novel, carbohydrate signal-mediated cell surface protein phosphorylation: ganglioside GQ1b stimulates ecto-protein kinase activity on the cell surface of a human neuroblastoma cell line, GOTO

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12 December 2020

Promotion of survival and neurite outgrowth of cultured peripheral neurons by exogenous lipids and detergents.

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12 December 2020

Exogenous glycosphingolipids suppress growth rate of transformed and untransformed 3T3 mouse cells

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12 December 2020

Induction of virus enzymes by phorbol esters and n-butyrate in Epstein-Barr virus genome-carrying Raji cells

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12 December 2020

Forskolin and phorbol esters decrease the same K+ conductance in cultured oligodendrocytes

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12 December 2020

Quantitation of free sphingosine in liver by high-performance liquid chromatography

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12 December 2020

Choline, phosphatidylcholine and sphingomyelin in human and bovine milk and infant formulas

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12 December 2020

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation

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12 December 2020

Growth control of human foreskin fibroblasts and inhibition of extracellular sialidase activity by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid

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12 December 2020

Sustained dendritic gradients of Ca2+ induced by excitatory amino acids in CA1 hippocampal neurons

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12 December 2020

Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action

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12 December 2020

Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles

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12 December 2020

Dexamethasone and sphingolipids inhibit concanavalin A stimulated glucose uptake in 3T3-L1 fibroblasts

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12 December 2020

Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction

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12 December 2020

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation

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12 December 2020

Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells

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12 December 2020

Phospholipid remodeling in human neutrophils. Parallel activation of a deacylation/reacylation cycle and platelet-activating factor synthesis

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12 December 2020

Synthetic sialyl compounds as well as natural gangliosides induce neuritogenesis in a mouse neuroblastoma cell line (Neuro2a).

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12 December 2020

Sphingosine inhibits phorbol ester-induced inflammation, ornithine decarboxylase activity, and activation of protein kinase C in mouse skin

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12 December 2020

Sphingosine inhibits thyrotropin-releasing hormone binding to pituitary cells by a mechanism independent of protein kinase C

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12 December 2020

Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s).

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12 December 2020

Enzymatic quantification of sphingosine in the picomole range in cultured cells.

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12 December 2020

Gangliosides inhibit phospholipid-sensitive Ca2+-dependent kinase phosphorylation of rat myelin basic proteins.

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12 December 2020

Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells

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12 December 2020

Comparative analysis of mammalian plasma lipoproteins

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12 December 2020

Augmentation of lymphocyte responses by monoclonal antibodies to the gangliosides GD3 and GD2: the role of protein kinase C, cyclic nucleotides, and intracellular calcium

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12 December 2020

Biosynthesis of paf-acether. X. Phorbol myristate acetate-induced paf-acether biosynthesis and acetyltransferase activation in human neutrophils.

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12 December 2020

An update of the enzymology and regulation of sphingomyelin metabolism

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12 December 2020

Infantile and fetal globoid cell leukodystrophy: analysis of galactosylceramide and galactosylsphingosine

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12 December 2020

Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affectin

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12 December 2020

Biosynthesis and localization of gangliosides in cultured cells.

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12 December 2020

Sphingomyelins in bilayers and biological membranes

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12 December 2020

Salvage of glucosylceramide by recycling after internalization along the pathway of receptor-mediated endocytosis

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12 December 2020

In Vivo Studies on the Introduction of the 4-t-Double Bond of the Sphingenine Moiety of Rat Brain Ceramides

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12 December 2020

Different metabolic recycling of the lipid components of exogenous sulphatide in human fibroblasts

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12 December 2020

Inhibition of protein kinase C by sphingosine correlates with the presence of positive charge

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12 December 2020

Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferation

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12 December 2020

Modulation of protein kinase C and diverse cell functions by sphingosine--a pharmacologically interesting compound linking sphingolipids and signal transduction

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12 December 2020

Evidence that neutral spingomyelinase of cultured murine neuroblastoma cells is oriented externally on the plasma membrane

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12 December 2020

Ganglioside stimulation of axonal sprouting in vitro

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12 December 2020

Differential effects of long-chain (sphingoid) bases on the monocytic differentiation of human leukemia (HL-60) cells induced by phorbol esters, 1 alpha, 25-dihydroxyvitamin D3, or ganglioside GM3.

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12 December 2020

Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils

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12 December 2020

Effects of luminal Na+ on single Na+ channels in A6 cells, a regulatory role for protein kinase C.

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12 December 2020

Differential effect of ganglioside GM1 on rat brain phosphoproteins: potentiation and inhibition of protein phosphorylation regulated by calcium/calmodulin and calcium/phospholipid-dependent protein kinases

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12 December 2020

Toxicity of some charged lipids used in liposome preparations

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12 December 2020

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal growth factor receptor.

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12 December 2020

Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses

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12 December 2020

Acid and alkaline ceramidases of rat tissues.

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12 December 2020

Sphingomyelin synthase and PKC activation

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12 December 2020

Role of membrane gangliosides in the binding and action of bacterial toxins.

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12 December 2020

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

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12 December 2020

Complement C5b-9-stimulated platelet secretion is associated with a Ca2+-initiated activation of cellular protein kinases

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12 December 2020

An acidic glycosphingolipid, monosialo-ganglioside GM3, is a potent physiological inducer for monocytic differentiation of human promyelocytic leukemia cell line HL-60 cells

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12 December 2020

Biology of gangliosides: neuritogenic and neuronotrophic properties

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12 December 2020

Inhibition of the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate in mouse skin by sphingosine sulfate

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12 December 2020

The gangliosides of adult human aorta: intima, media and plaque

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12 December 2020

Activation of the respiratory burst oxidase in neutrophils: on the role of membrane-derived second messengers, Ca++, and protein kinase C.

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12 December 2020

Regulation of RAW264 macrophage morphology and spreading: studies with protein kinase C activators, inhibitors and a cyclic AMP analog

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12 December 2020

Sphingomyelinase activity at pH 7.4 in human brain and a comparison to activity at pH 5.0

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12 December 2020

Ganglioside-modulated protein phosphorylation. Partial purification and characterization of a ganglioside-stimulated protein kinase in brain.

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12 December 2020

Functions of sphingolipids and sphingolipid breakdown products in cellular regulation

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12 December 2020

Sphingosine inhibits phorbol 12-myristate 13-acetate-, but not serum-induced, activation of Na+/H+ exchange in mammalian cells

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12 December 2020

Antitumor activity via inhibition of glycosphingolipid biosynthesis.

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12 December 2020

Glycosphingolipids in cellular interaction, differentiation, and oncogenesis

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12 December 2020

Activation of the purified protein tyrosine kinase domain of the epidermal growth factor receptor.

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12 December 2020

Free sphingoid bases in normal murine tissues

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12 December 2020

Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils

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12 December 2020

Phorbol ester-associated changes in ganglioside metabolism

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12 December 2020

Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol

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12 December 2020

Activation of CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase during the differentiation of HL-60 cells induced by 12-O-tetradecanoylphorbol-13-acetate

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12 December 2020

Insulin and phorbol ester stimulate conductive Na+ transport through a common pathway.

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12 December 2020

Phosphoinositide breakdown and evidence for protein kinase C involvement during human NK killing

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12 December 2020

A further comparison of insulin- and phorbol ester-stimulated glucose transport in adipocytes

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12 December 2020

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets

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12 December 2020

Biosynthesis and Function of Gangliosides

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12 December 2020

1,2-Diacylglycerols, but not phorbol esters, activate a potential inhibitory pathway for protein kinase C in GH3 pituitary cells. Evidence for involvement of a sphingomyelinase.

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12 December 2020

Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding

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12 December 2020

Insulin-stimulated hexose transport and glucose oxidation in rat adipocytes is inhibited by sphingosine at a step after insulin binding.

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12 December 2020

On the chemistry and occurrence of sphingolipid long-chain bases

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12 December 2020

Identifiers

DOI

10.1007/BF00768840

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