(Q37690470)

22 August 2017

In vitro and in vivo efficacy of SYL040012, a novel siRNA compound for treatment of glaucoma (English)

1 reference

22 August 2017

Tamara Martínez

1

1 reference

22 August 2017

Maria Victoria González

2

1 reference

22 August 2017

Ingo Roehl

3

1 reference

22 August 2017

Natalia Wright

4

1 reference

22 August 2017

Covadonga Pañeda

5

1 reference

22 August 2017

Ana Isabel Jiménez

6

1 reference

22 August 2017

12 September 2013

1 reference

22 August 2017

1 reference

22 August 2017

22

1 reference

22 August 2017

1

1 reference

22 August 2017

81-91

1 reference

Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

An assessment of the health and economic burdens of glaucoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Ocular neuroprotection by siRNA targeting caspase-2

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Aqueous humor dynamics: a review

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

RNA interference technologies and therapeutics: from basic research to products

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Pharmacogenetics of ophthalmic topical beta-blockers

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Cardiovascular and respiratory considerations with pharmacotherapy of glaucoma and ocular hypertension

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

RNAi therapeutics: principles, prospects and challenges

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Ophthalmic timolol: plasma concentration and systemic cardiopulmonary effects.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Challenges and obstacles of ocular pharmacokinetics and drug delivery

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Progress towards in vivo use of siRNAs

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

In vivo application of RNA interference: from functional genomics to therapeutics

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Glaucoma is second leading cause of blindness globally

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

23 August 2017

Glaucoma--1: diagnosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

ATP requirements and small interfering RNA structure in the RNA interference pathway

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Selection in vitro of novel ribozymes from a partially randomized U2 and U6 snRNA library

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Oligo safety working group exaggerated pharmacology subcommittee consensus document

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Intraocular pressure: modulation as treatment for glaucoma.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Effects of common topical antiglaucoma medications on the ocular surface, eyelids and periorbital tissue.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Stability study of unmodified siRNA and relevance to clinical use.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Comparative efficacy of pilocarpine, timolol and latanoprost in experimental models of glaucoma.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Topical ophthalmic beta blockers: a comparative review

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Phase III latanoprost studies in Scandinavia, the United Kingdom and the United States.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Beta adrenergic receptors in pigmented ciliary processes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Importance of the noncorneal absorption route in topical ophthalmic drug delivery

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Paracellular permeability of corneal and conjunctival epithelia

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Efficiency of glaucoma drug regulation in 5 European countries: a 1995-2006 longitudinal prescription analysis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Potent reduction of intraocular pressure by nipradilol plus latanoprost in ocular hypertensive rabbits

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3978804

Efficient intraocular penetration of topical anti-TNF-alpha single-chain antibody (ESBA105) to anterior and posterior segment without penetration enhancer

1 September 2018

1 reference

12 December 2020

The effect of topical diltiazem on ocular hypertension induced by water loading in rabbits

1 reference

12 December 2020

Distribution and properties of beta-adrenergic receptors in human iris-ciliary body

1 reference

12 December 2020

An improved model of experimentally induced ocular hypertension in the rabbit

1 reference

12 December 2020

Comparison of the ocular distribution of a model oligonucleotide after topical instillation in rabbits of conventional and new dosage forms

1 reference

12 December 2020

Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera

1 reference

12 December 2020

Beta adrenergic binding sites in the human eye: an autoradiographic study

1 reference

12 December 2020

1 reference

12 December 2020

Transitory models of experimentally induced intraocular pressure changes in the rabbit. A reappraisal

1 reference

12 December 2020

Differential inhibition of beta adrenergic receptors in human and rabbit ciliary process and heart

1 reference

12 December 2020

Autoradiographic localization of beta-adrenergic receptors in rabbit eye

1 reference

12 December 2020

Identifiers

DOI

10.1038/MT.2013.216

1 reference

22 August 2017

1 reference

22 August 2017

PubMed publication ID

24025749

1 reference