(Q37697791)

22 August 2017

1 reference

title

Orexin receptor antagonists: a review of promising compounds patented since 2006. (English)

1 reference

22 August 2017

0 references

Paul J Coleman

1

1 reference

PubMed ID

20180618

22 August 2017

John J Renger

series ordinal

2

1 reference

PubMed ID

20180618

22 August 2017

language of work or name

English

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publication date

1 March 2010

1 reference

Expert Opinion on Therapeutic Patents

22 August 2017

1 reference

22 August 2017

20

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22 August 2017

3

1 reference

22 August 2017

307-324

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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

22 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Clinical and neurobiological aspects of narcolepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Behavioral state instability in orexin knock-out mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Differential expression of orexin receptors 1 and 2 in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Inhibitory effect of exogenous orexin a on gastric emptying, plasma leptin, and the distribution of orexin and orexin receptors in the gut and pancreas in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

The signalling profile of recombinant human orexin-2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Development of cataplexy in genetically narcoleptic Dobermans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Orexin receptor antagonists: medicinal chemistry and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Biomedical application of orexin/hypocretin receptor ligands in neuroscience

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Promotion of sleep by targeting the orexin system in rats, dogs and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

A role for lateral hypothalamic orexin neurons in reward seeking

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Addiction and arousal: alternative roles of hypothalamic peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Role of lateral hypothalamic orexin neurons in reward processing and addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Proline bis-amides as potent dual orexin receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903567085

10.1517/13543770903567085

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20180618