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English
ErbB2 inhibition by lapatinib promotes degradation of mutant p53 protein in cancer cells.
scientific article published on 25 October 2016
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
5351592
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27791982%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
title
ErbB2 inhibition by lapatinib promotes degradation of mutant p53 protein in cancer cells
(English)
1 reference
stated in
Europe PubMed Central
PMCID
5351592
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27791982%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
author
Dun Li
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
5351592
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27791982%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
author name string
Natalia D Marchenko
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
5351592
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27791982%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
language of work or name
English
0 references
publication date
1 January 2017
1 reference
stated in
Europe PubMed Central
PMCID
5351592
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27791982%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
published in
Oncotarget
1 reference
stated in
Europe PubMed Central
PMCID
5351592
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27791982%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
volume
8
1 reference
stated in
Europe PubMed Central
PMCID
5351592
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27791982%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
issue
4
1 reference
stated in
Europe PubMed Central
PMCID
5351592
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27791982%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
page(s)
5823-5833
1 reference
stated in
Europe PubMed Central
PMCID
5351592
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27791982%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
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A gain-of-function mutant p53-HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress
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Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling
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Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells
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HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer
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Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis
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Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis
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PubMed Central
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23 August 2017
Mutant p53: one name, many proteins
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23 August 2017
Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort
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23 August 2017
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
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23 August 2017
The epidermal growth factor receptor/Erb-B/HER family in normal and malignant breast biology
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23 August 2017
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer
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PubMed Central
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23 August 2017
Early onset HER2-positive breast cancer is associated with germline TP53 mutations
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PubMed Central
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23 August 2017
Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells
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23 August 2017
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
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23 August 2017
When mutants gain new powers: news from the mutant p53 field.
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23 August 2017
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
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23 August 2017
Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351592
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23 August 2017
The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351592
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23 August 2017
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
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23 August 2017
Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors
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23 August 2017
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
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23 August 2017
Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer
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PubMed Central
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23 August 2017
The Evolving Landscape of HER2 Targeting in Breast Cancer
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6 September 2017
Mutant p53 drives invasion by promoting integrin recycling
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14 September 2017
Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis
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14 September 2017
Geldanamycin selectively destabilizes and conformationally alters mutated p53.
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351592
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28 September 2017
TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351592
retrieved
23 June 2018
Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351592
retrieved
1 September 2018
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351592
retrieved
1 September 2018
Corrigendum: Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27791982
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.18632/ONCOTARGET.12878
1 reference
stated in
Europe PubMed Central
PMCID
5351592
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27791982%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
PMCID
5351592
1 reference
stated in
Europe PubMed Central
PMCID
5351592
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27791982%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
PubMed ID
27791982
1 reference
stated in
Europe PubMed Central
PMCID
5351592
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27791982%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
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