(Q37727999)

22 August 2017

1 reference

title

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels in the regulation of midbrain dopamine systems (English)

1 reference

22 August 2017

0 references

Hong-yuan Chu

1

1 reference

PMCID

4002296

22 August 2017

Xuechu Zhen

series ordinal

2

1 reference

PMCID

4002296

22 August 2017

language of work or name

1 reference

2 August 2010

1 reference

Acta Pharmacologica Sinica

22 August 2017

1 reference

22 August 2017

31

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22 August 2017

9

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22 August 2017

1036-1043

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https://scigraph.springernature.com/pub.10.1038/aps.2010.105

22 August 2017

0 references

cites work

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Hyperpolarization-activated cation channels: from genes to function

23 August 2017

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Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons

23 August 2017

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Ethanol effects on dopaminergic ventral tegmental area neurons during block of Ih: involvement of barium-sensitive potassium currents

23 August 2017

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Chemical transmission between dopaminergic neuron pairs

23 August 2017

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Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system

23 August 2017

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'Rejuvenation' protects neurons in mouse models of Parkinson's disease

23 August 2017

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Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex.

23 August 2017

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The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm

23 August 2017

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Regulation of firing of dopaminergic neurons and control of goal-directed behaviors

23 August 2017

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Glutamatergic neurons are present in the rat ventral tegmental area

23 August 2017

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Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2

23 August 2017

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Mesocortical dopamine modulation of executive functions: beyond working memory

23 August 2017

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Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location

23 August 2017

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Hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice

23 August 2017

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The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse?

23 August 2017

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A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase

23 August 2017

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Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain

23 August 2017

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Prefrontal DA Transmission at D1 Receptors and the Pathology of Schizophrenia

23 August 2017

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Hyperpolarization-activated cation currents: from molecules to physiological function

23 August 2017

1 reference

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Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions

23 August 2017

1 reference

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Evidence for a modulatory role of Ih on the firing of a subgroup of midbrain dopamine neurons

23 August 2017

1 reference

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Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS.

23 August 2017

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Can calcium antagonists provide a neuroprotective effect in Parkinson's disease?

23 August 2017

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A family of hyperpolarization-activated mammalian cation channels

23 August 2017

1 reference

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D1 dopamine receptor immunoreactivity in human and monkey cerebral cortex: predominant and extrasynaptic localization in dendritic spines

23 August 2017

1 reference

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The control of firing pattern in nigral dopamine neurons: burst firing

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia

23 August 2017

1 reference

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Ventral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity

23 August 2017

1 reference

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Parkinson's disease: from brain homogenate to treatment

14 September 2017

1 reference

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Noradrenergic modulation of the hyperpolarization-activated cation current (Ih) in dopamine neurons of the ventral tegmental area

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Pacemaker channels in mouse thalamocortical neurones are regulated by distinct pathways of cAMP synthesis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Enhancement of synaptic transmission by cyclic AMP modulation of presynaptic Ih channels

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

The effects of ethanol on dopaminergic neurons of the ventral tegmental area studied with intracellular recording in brain slices.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Baclofen inhibition of the hyperpolarization-activated cation current, Ih, in rat substantia nigra zona compacta neurons may be secondary to potassium current activation.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Nifedipine- and omega-conotoxin-sensitive Ca2+ conductances in guinea-pig substantia nigra pars compacta neurones

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Effects of dihydropyridine calcium antagonists on rat midbrain dopaminergic neurones

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons--2. Action potential generating mechanisms and morphological correlates.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons--1. Identification and characterization.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Serotonin augments the cationic current Ih in central neurons

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Noradrenergic and serotonergic modulation of a hyperpolarization-activated cation current in thalamic relay neurones

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

A modeling study suggesting a possible pharmacological target to mitigate the effects of ethanol on reward-related dopaminergic signaling

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

HCN1 channels control resting and active integrative properties of stellate cells from layer II of the entorhinal cortex.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Roles of subthreshold calcium current and sodium current in spontaneous firing of mouse midbrain dopamine neurons.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Pacemaking by HCN channels requires interaction with phosphoinositides.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Modulation of h-channels in hippocampal pyramidal neurons by p38 mitogen-activated protein kinase.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Serotonin reduces the hyperpolarization-activated current (Ih) in ventral tegmental area dopamine neurons: involvement of 5-HT2 receptors and protein kinase C.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Ethanol Excitation of Dopaminergic Ventral Tegmental Area Neurons Is Blocked by Quinidine

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Postnatal development of the hyperpolarization-activated excitatory current Ih in mouse hippocampal pyramidal neurons.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Molecular mechanism of cAMP modulation of HCN pacemaker channels.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Calcium dynamics underlying pacemaker-like and burst firing oscillations in midbrain dopaminergic neurons: a computational study.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Effect of catecholamines on the hyperpolarization-activated cationic Ih and the inwardly rectifying potassium I(Kir) currents in the rat substantia nigra pars compacta.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Heterogeneity of ventral tegmental area neurons: single-unit recording and iontophoresis in awake, unrestrained rats.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Neurotensin inhibition of the hyperpolarization-activated cation current (Ih) in the rat substantia nigra pars compacta implicates the protein kinase C pathway.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Opioid inhibition of Ih via adenylyl cyclase

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002296

Single-cell mRNA expression of HCN1 correlates with a fast gating phenotype of hyperpolarization-activated cyclic nucleotide-gated ion channels (Ih) in central neurons

1 September 2018

1 reference

12 December 2020

Determinants of activation kinetics in mammalian hyperpolarization-activated cation channels

1 reference

12 December 2020

A new interpretation of the pace-maker current in calf Purkinje fibres

1 reference

12 December 2020

Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids

1 reference

12 December 2020

Properties of the hyperpolarization-activated cation current Ih in rat midbrain dopaminergic neurons

1 reference

12 December 2020

Burst firing in midbrain dopaminergic neurons

1 reference

12 December 2020

Identifiers

DOI

10.1038/APS.2010.105

1 reference

22 August 2017

1 reference

22 August 2017

1 reference

PMCID

4002296