(Q37731854)

22 August 2017

Defining a therapeutic window for the novel TGF-β inhibitor LY2157299 monohydrate based on a pharmacokinetic/pharmacodynamic model (English)

1 reference

22 August 2017

1 reference

ChEBI release 2020-05-28

1 reference

1 reference

Ivelina Gueorguieva

1

1 reference

22 August 2017

Ann L Cleverly

2

1 reference

22 August 2017

Anja Stauber

3

1 reference

22 August 2017

N Sada Pillay

4

1 reference

22 August 2017

Jordi A Rodon

5

1 reference

22 August 2017

Colin P Miles

6

1 reference

22 August 2017

Jonathan M Yingling

7

1 reference

22 August 2017

Michael M Lahn

8

1 reference

22 August 2017

language of work or name

English

0 references

publication date

1 May 2014

1 reference

British Journal of Clinical Pharmacology

22 August 2017

1 reference

22 August 2017

77

1 reference

22 August 2017

5

1 reference

22 August 2017

796-807

1 reference

TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

Impact of pharmacometrics on drug approval and labeling decisions: a survey of 42 new drug applications

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

Development of TGF-beta signalling inhibitors for cancer therapy

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

TGF-beta signaling: positive and negative effects on tumorigenesis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

TGF-beta signaling in tumor suppression and cancer progression

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

Smads: transcriptional activators of TGF-beta responses

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

Elucidation of relationship between tumor size and survival in non-small-cell lung cancer patients can aid early decision making in clinical drug development

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

Induction of heart valve lesions by small-molecule ALK5 inhibitors.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

Response criteria for phase II studies of supratentorial malignant glioma

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004400

A program for individual and population optimal design for univariate and multivariate response pharmacokinetic-pharmacodynamic models

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24868575

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24868575

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/BCP.12256

1 reference

release_4bg5j37mbvaizkrb5d7ktcl6ha

22 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4bg5j37mbvaizkrb5d7ktcl6ha

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

22 August 2017

PubMed publication ID

24868575

1 reference