(Q37753210)

English

NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-2220976)

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Statements

biological process

1 reference

8 July 2022

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-2220976

1 reference

8 July 2022

NOTCH1 HD+PEST Domain Mutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane]

1

object has role

1 reference

8 July 2022

NEXT1 PEST domain mutants [plasma membrane]

1

object has role

1 reference

8 July 2022

NOTCH1 HD+PEST Domain Mutant Fragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane]

1

object has role

1 reference

8 July 2022

ADAM10/17:Zn2+ [plasma membrane]

1

object has role

1 reference

8 July 2022

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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