(Q37753187)

English

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2894862)

In more languages

edit

Statements

1 reference

8 July 2022

Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-2894862

1 reference

8 July 2022

NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants

1 reference

8 July 2022

NICD1 PEST domain mutants translocate from cytosol to nucleus

1 reference

8 July 2022

NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)

1 reference

8 July 2022

NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML

1 reference

8 July 2022

NOTCH1 PEST domain mutants stimulate HES1 transcription

1 reference

8 July 2022

NOTCH1 PEST domain mutants bind HES1 promoter

1 reference

8 July 2022

NOTCH1 PEST domain mutants bind HES5 promoter

1 reference

8 July 2022

NOTCH1 PEST domain mutants stimulate HES5 transcription

1 reference

8 July 2022

NOTCH1 PEST domain mutants bind promoters of HEY genes

1 reference

8 July 2022

NOTCH1 PEST domain mutants stimulate HEY transcription

1 reference

8 July 2022

NOTCH1 PEST domain mutants bind MYC promoter

1 reference

8 July 2022

NOTCH1 PEST domain mutants stimulate MYC transcription

1 reference

8 July 2022

NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC

1 reference

8 July 2022

CDK8 phosphorylates NICD1 PEST domain mutants

1 reference

8 July 2022

p-NICD1 PEST domain mutants do not bind FBXW7

1 reference

8 July 2022

NOTCH1 HD+PEST domain mutants bind DLL1

1 reference

8 July 2022

NOTCH1 HD+PEST domain mutants bind DLL4

1 reference

8 July 2022

NOTCH1 HD+PEST domain mutants bind JAG1

1 reference

8 July 2022

NOTCH1 HD+PEST domain mutants bind JAG2

1 reference

8 July 2022

NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding

1 reference

8 July 2022

Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants

1 reference

8 July 2022

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

1 reference

8 July 2022

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

1 reference

8 July 2022

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

1 reference

8 July 2022

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q37753187)

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)