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p-NICD1 PEST domain mutants do not bind FBXW7
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-2220967)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2220967
part of
Constitutive Signaling by NOTCH1 PEST Domain Mutants
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2220967
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2220967
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2220967
exact match
https://identifiers.org/reactome:R-HSA-2220967
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2220967
has part(s)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2220967
p-NICD1 PEST domain mutants [nucleoplasm]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2220967
cites work
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2220967
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2220967
Identifiers
Reactome ID
R-HSA-2220967
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2220967
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