(Q37753086)

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Constitutive Signaling by NOTCH1 PEST Domain Mutants

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2644606)

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1 reference

8 July 2022

Signaling by NOTCH1 PEST Domain Mutants in Cancer

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-2644606

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8 July 2022

NOTCH1 PEST domain mutants bind DLL1

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8 July 2022

NOTCH1 PEST domain mutants bind DLL4

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8 July 2022

NOTCH1 PEST domain mutants bind JAG1

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8 July 2022

NOTCH1 PEST domain mutants bind JAG2

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8 July 2022

Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants

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8 July 2022

ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants

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8 July 2022

NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants

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8 July 2022

NICD1 PEST domain mutants translocate from cytosol to nucleus

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8 July 2022

NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)

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8 July 2022

NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML

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8 July 2022

NOTCH1 PEST domain mutants bind HES1 promoter

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8 July 2022

NOTCH1 PEST domain mutants stimulate HES1 transcription

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8 July 2022

NOTCH1 PEST domain mutants bind HES5 promoter

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8 July 2022

NOTCH1 PEST domain mutants stimulate HES5 transcription

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8 July 2022

NOTCH1 PEST domain mutants bind promoters of HEY genes

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8 July 2022

NOTCH1 PEST domain mutants stimulate HEY transcription

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8 July 2022

NOTCH1 PEST domain mutants bind MYC promoter

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8 July 2022

NOTCH1 PEST domain mutants stimulate MYC transcription

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8 July 2022

NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC

1 reference

8 July 2022

CDK8 phosphorylates NICD1 PEST domain mutants

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8 July 2022

p-NICD1 PEST domain mutants do not bind FBXW7

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8 July 2022

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

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8 July 2022

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

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8 July 2022

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q37753086)

Constitutive Signaling by NOTCH1 PEST Domain Mutants

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