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Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2644607)
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Statements
instance of
biological pathway
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2644607
part of
FBXW7 Mutants and NOTCH1 in Cancer
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2644607
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2644607
exact match
https://identifiers.org/reactome:R-HSA-2644607
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2644607
has part(s)
FBXW7 WD mutants do not bind NICD1
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2644607
cites work
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2644607
Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2644607
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2644607
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2644607
Identifiers
Reactome ID
R-HSA-2644607
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2644607
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