(Q37754789)

English

FBXW7 Mutants and NOTCH1 in Cancer

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2644605)

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Statements

biological pathway

1 reference

8 July 2022

Signaling by NOTCH1 in Cancer

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-2644605

1 reference

8 July 2022

Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling

1 reference

8 July 2022

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

1 reference

8 July 2022

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

1 reference

8 July 2022

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

1 reference

8 July 2022

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

1 reference

8 July 2022

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

1 reference

8 July 2022

FBXW7/hCDC4 is a general tumor suppressor in human cancer.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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