(Q37773268)

22 August 2017

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title

Harnessing regulatory T cells for the therapy of lupus and other autoimmune diseases (English)

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22 August 2017

Amir Sharabi

1

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PubMed ID

20635958

22 August 2017

Edna Mozes

series ordinal

2

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22 August 2017

1 May 2009

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22 August 2017

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22 August 2017

1

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22 August 2017

3

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22 August 2017

385-401

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Regulatory T cells and immune tolerance

22 August 2017

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Polyclonal anti-T-cell therapy for type 1 diabetes mellitus of recent onset

21 January 2018

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The T lymphocyte in experimental allergic encephalomyelitis

21 January 2018

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The dynamics of effector T cells and Foxp3+ regulatory T cells in the promotion and regulation of autoimmune encephalomyelitis

21 January 2018

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Autoreactive T cells in murine lupus: origins and roles in autoantibody production

21 January 2018

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CD4(+) T cells from lupus-prone mice are hyperresponsive to T cell receptor engagement with low and high affinity peptide antigens: a model to explain spontaneous T cell activation in lupus

21 January 2018

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T cell epitope mapping of the Smith antigen reveals that highly conserved Smith antigen motifs are the dominant target of T cell immunity in systemic lupus erythematosus

21 January 2018

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Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice

21 January 2018

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Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype

21 January 2018

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A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus

21 January 2018

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Modulation of SLE induction in naive mice by specific T cells with suppressor activity to pathogenic anti-DNA idiotype

21 January 2018

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Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

21 January 2018

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Natural versus adaptive regulatory T cells

21 January 2018

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Antigen-induced regulatory T cells in autoimmunity

21 January 2018

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Imbalance of regulatory T cells in human autoimmune diseases

21 January 2018

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Regulatory T cells in spontaneous autoimmune encephalomyelitis

21 January 2018

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Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis

21 January 2018

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Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease

21 January 2018

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Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia gravis

21 January 2018

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Down-regulation of myasthenogenic T cell responses by a dual altered peptide ligand via CD4+CD25+-regulated events leading to apoptosis

21 January 2018

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Suppression of myasthenogenic responses of a T cell line by a dual altered peptide ligand by induction of CD4+CD25+ regulatory cells

21 January 2018

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In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

21 January 2018

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TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

21 January 2018

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Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice

21 January 2018

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Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus.

21 January 2018

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Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus

21 January 2018

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Anti-DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patients

21 January 2018

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The role of CD4CD25 T cells in autoantibody production in murine lupus.

21 January 2018

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A deficiency of CD4+CD25+ T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen

21 January 2018

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Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells

21 January 2018

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The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice

21 January 2018

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Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus

21 January 2018

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Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA.

21 January 2018

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Induction of immune tolerance by activation of CD8+ T suppressor/regulatory cells in lupus-prone mice

21 January 2018

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The role of CD8 suppressors versus destructors in autoimmune central nervous system inflammation

21 January 2018

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Inhibitory CD8+ T cells in autoimmune disease

21 January 2018

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Regulatory functions of CD8+CD28– T cells in an autoimmune disease model

21 January 2018

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Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodies

21 January 2018

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CD8+CD28- regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice

21 January 2018

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The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand

21 January 2018

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Regulatory T cells in patients with systemic lupus erythematosus.

21 January 2018

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Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3-expressing, apoptosis-resistant, TGFbeta-secreting CD8+ T cell suppressors

21 January 2018

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CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression.

21 January 2018

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pConsensus peptide induces tolerogenic CD8+ T cells in lupus-prone (NZB x NZW)F1 mice by differentially regulating Foxp3 and PD1 molecules

21 January 2018

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Suppressor T cells--they're back and critical for regulation of autoimmunity!

21 January 2018

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Control of regulatory T cell development by the transcription factor Foxp3

21 January 2018

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

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Neuropilin-1: a surface marker of regulatory T cells

21 January 2018

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Foxp3 and natural regulatory T cells: key to a cell lineage?

21 January 2018

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Lack of Foxp3 function and expression in the thymic epithelium

21 January 2018

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21 January 2018

The B7-CD28 superfamily

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

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Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

21 January 2018

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Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes

21 January 2018

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Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

21 January 2018

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T-cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens

21 January 2018

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Modulation of tryptophan catabolism by regulatory T cells.

21 January 2018

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Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression

21 January 2018

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CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells.

21 January 2018

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Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

21 January 2018

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Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

21 January 2018

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CTLA-4 control over Foxp3+ regulatory T cell function

21 January 2018

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Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

21 January 2018

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TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

21 January 2018

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A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood

21 January 2018

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T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

21 January 2018

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TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling

21 January 2018

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Mechanisms of suppression by suppressor T cells

21 January 2018

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Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses

21 January 2018

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PD-1 and its ligands in tolerance and immunity

21 January 2018

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Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.

21 January 2018

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

21 January 2018

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Human CD4+CD25+ regulatory T cells share equally complex and comparable repertoires with CD4+CD25- counterparts

21 January 2018

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Immune regulation by self-reactive T cells is antigen specific.

21 January 2018

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Peripheral autoantigen induces regulatory T cells that prevent autoimmunity

21 January 2018

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CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

21 January 2018

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Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice

21 January 2018

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Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice.

21 January 2018

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Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitis

21 January 2018

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Cutting edge: Autoimmune disease in day 3 thymectomized mice is actively controlled by endogenous disease-specific regulatory T cells

21 January 2018

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In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro

21 January 2018

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In vivo instruction of suppressor commitment in naive T cells

21 January 2018

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Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen

21 January 2018

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The role of the transcription factor Foxp3 in the development of regulatory T cells

21 January 2018

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Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors

21 January 2018

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CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

21 January 2018

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

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Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

21 January 2018

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The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens

21 January 2018

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TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells

21 January 2018

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FOXP3 controls regulatory T cell function through cooperation with NFAT

21 January 2018

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CTLA-4 x Ig converts naive CD4+CD25- T cells into CD4+CD25+ regulatory T cells.

21 January 2018

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TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cells

21 January 2018

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CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness

21 January 2018

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TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3.

21 January 2018

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IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells

21 January 2018

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Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen

21 January 2018

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

21 January 2018

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Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

21 January 2018

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How regulatory T cells work

21 January 2018

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The inhibitory cytokine IL-35 contributes to regulatory T-cell function

21 January 2018

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The role of apoptosis in the ameliorating effects of a CDR1-based peptide on lupus manifestations in a mouse model.

21 January 2018

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A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4+CD25+ cells and TGF-beta

21 January 2018

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Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway

21 January 2018

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JNK1 is required for T cell-mediated immunity against Leishmania major infection.

21 January 2018

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Activation-induced cell death in T cells

21 January 2018

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Cutting edge: amelioration of kidney disease in a transgenic mouse model of lupus nephritis by administration of the caspase inhibitor carbobenzoxy-valyl-alanyl-aspartyl-(beta-o-methyl)-fluoromethylketone

21 January 2018

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21 January 2018

Key autoantigens in SLE.

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Apoptosis in the pathogenesis of systemic lupus erythematosus.

21 January 2018

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Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE).

21 January 2018

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Clinical amelioration of murine lupus by a peptide based on the complementarity determining region-1 of an autoantibody and by cyclophosphamide: similarities and differences in the mechanisms of action

21 January 2018

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Function of CD4+,CD25+ Treg cells in MRL/lpr mice is compromised by intrinsic defects in antigen-presenting cells and effector T cells

21 January 2018

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Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells

21 January 2018

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CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cells

21 January 2018

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Cutting Edge: TGF- Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/IMT.09.2

1 reference

22 August 2017

1 reference

PubMed ID

20635958