(Q37778607)

23 August 2017

1 reference

title

Vascular remodeling in pulmonary arterial hypertension: multiple cancer-like pathways and possible treatment modalities (English)

1 reference

23 August 2017

Vascular remodeling in pulmonary arterial hypertension: Multiple cancer-like pathways and possible treatment modalities (English)

1 reference

https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

microvasculature remodeling

18 June 2024

main subject

arterial hypertension

0 references

1 reference

Seiichiro Sakao

1

1 reference

23 August 2017

Koichiro Tatsumi

2

1 reference

23 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20692712

18 June 2024

publication date

7 August 2010

1 reference

full work available at URL

23 August 2017

https://api.elsevier.com/content/article/PII:S0167527310005309?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

https://api.elsevier.com/content/article/PII:S0167527310005309?httpAccept=text/plain

18 June 2024

1 reference

https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

International Journal of Cardiology

18 June 2024

published in

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23 August 2017

volume

147

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23 August 2017

issue

1

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23 August 2017

page(s)

4-12

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Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells.

23 August 2017

cites work

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30 December 2023

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18 June 2024

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Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension

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18 June 2024

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18 June 2024

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Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis

18 June 2024

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Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

18 June 2024

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VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34+ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells

18 June 2024

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Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells

18 June 2024

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Transforming growth factor-beta(1) stimulates L-arginine transport and metabolism in vascular smooth muscle cells: role in polyamine and collagen synthesis

18 June 2024

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Apoptosis of pulmonary microvascular endothelial cells stimulates vascular smooth muscle cell growth

18 June 2024

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Mechanism of action and in vivo role of platelet-derived growth factor

18 June 2024

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A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro

18 June 2024

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Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus

18 June 2024

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Reversal of experimental pulmonary hypertension by PDGF inhibition

18 June 2024

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Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension

18 June 2024

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Role of epidermal growth factor inhibition in experimental pulmonary hypertension.

18 June 2024

26

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Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

18 June 2024

27

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Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension

18 June 2024

28

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Chronic hypoxia induces exaggerated growth responses in pulmonary artery adventitial fibroblasts: potential contribution of specific protein kinase c isozymes.

18 June 2024

29

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Low oxygen stimulates proliferation of fibroblasts seeded as single cells

18 June 2024

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Oxygen concentration regulates the proliferative response of human fibroblasts to serum and growth factors

18 June 2024

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Hypoxia enhances proliferation and generation of IP3 in pulmonary artery fibroblasts but not in those from the mesenteric circulation

18 June 2024

32

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Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmonary but not systemic arteries

18 June 2024

33

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Hypoxia enhances cellular proliferation and inositol 1,4, 5-triphosphate generation in fibroblasts from bovine pulmonary artery but not from mesenteric artery

18 June 2024

34

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia.

18 June 2024

35

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.

18 June 2024

36

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

CDK inhibitors: positive and negative regulators of G1-phase progression

18 June 2024

37

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Contact inhibition and malignancy

18 June 2024

38

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry

18 June 2024

39

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

18 June 2024

40

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

p27Kip1 expression by contact inhibition as a prognostic index of human glioma.

18 June 2024

41

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells

18 June 2024

42

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Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts

18 June 2024

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Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation

18 June 2024

44

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

p27(Kip1) is important in modulating pulmonary artery smooth muscle cell proliferation

18 June 2024

45

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice

18 June 2024

46

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TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights

18 June 2024

47

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Pulmonary hypertension due to BMPR2 mutation: a new paradigm for tissue remodeling?

18 June 2024

48

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BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension

18 June 2024

49

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BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK

18 June 2024

50

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Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis

18 June 2024

51

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Bone morphogenetic proteins and their receptor signaling in prostate cancer

18 June 2024

52

1 reference

https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms

18 June 2024

53

1 reference

https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitia

18 June 2024

54

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Cell death: the significance of apoptosis

18 June 2024

55

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension

18 June 2024

56

1 reference

https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Impaired apoptosis of pulmonary endothelial cells is associated with intimal proliferation and irreversibility of pulmonary hypertension in congenital heart disease

18 June 2024

57

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

IAP proteins: blocking the road to death's door

18 June 2024

58

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Validating survivin as a cancer therapeutic target

18 June 2024

59

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Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells

18 June 2024

60

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Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension.

18 June 2024

61

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Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension

18 June 2024

62

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Hypoxia-driven proliferation of human pulmonary artery fibroblasts: cross-talk between HIF-1α and an autocrine angiotensin system

18 June 2024

63

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NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts

18 June 2024

64

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https://api.crossref.org/works/10.1016/J.IJCARD.2010.07.003

Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature.

18 June 2024

65

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Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

18 June 2024

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Suppressing cancer: the importance of being senescent.

18 June 2024

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Telomeres shorten during ageing of human fibroblasts

18 June 2024

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How shelterin protects mammalian telomeres

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Telomeres and telomerase in cancer

18 June 2024

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A critical role for telomeres in suppressing and facilitating carcinogenesis

18 June 2024

72

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Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells

18 June 2024

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Clonal analysis of human colorectal tumors

18 June 2024

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Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension

18 June 2024

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Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension

18 June 2024

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How tumors become angiogenic

18 June 2024

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

18 June 2024

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Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells

18 June 2024

80

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Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells

18 June 2024

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The pathology of pulmonary artery hypertension

18 June 2024

82

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PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells

18 June 2024

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Pulmonary artery adventitial fibroblasts cooperate with vasa vasorum endothelial cells to regulate vasa vasorum neovascularization: a process mediated by hypoxia and endothelin-1.

18 June 2024

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Controlling the angiogenic switch in developing atherosclerotic plaques: possible targets for therapeutic intervention

18 June 2024

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18 June 2024

The war on cancer

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THE METABOLISM OF TUMORS IN THE BODY

18 June 2024

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On the Origin of Cancer Cells

18 June 2024

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Molecular imaging of cancer with positron emission tomography

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Alterations of cellular bioenergetics in pulmonary artery endothelial cells

18 June 2024

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Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

18 June 2024

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An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

18 June 2024

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The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted

18 June 2024

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Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling

18 June 2024

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Hypoxia- and non-hypoxia-related pulmonary hypertension - established and new therapies.

18 June 2024

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A dosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension.

18 June 2024

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18 June 2024

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Future perspectives for the treatment of pulmonary arterial hypertension

18 June 2024

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Imatinib for the treatment of pulmonary arterial hypertension

18 June 2024

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Imatinib Mesylate in the Treatment of Refractory Idiopathic Pulmonary Arterial Hypertension

18 June 2024

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Long term imatinib treatment in pulmonary arterial hypertension.

18 June 2024

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Possible role of imatinib in clinical pulmonary veno-occlusive disease

18 June 2024

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Evaluation of imatinib mesylate in the treatment of pulmonary arterial hypertension

18 June 2024

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Pulmonary arterial remodeling induced by a Th2 immune response

18 June 2024

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Ethical authorship and publishing.

18 June 2024

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18 June 2024

Identifiers

1 reference

23 August 2017

1 reference