(Q37786866)

23 August 2017

An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin (English)

1 reference

23 August 2017

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Yaremi Quiros

1

1 reference

23 August 2017

Laura Vicente-Vicente

2

1 reference

23 August 2017

Ana I Morales

3

1 reference

23 August 2017

José M López-Novoa

4

1 reference

23 August 2017

Francisco J López-Hernández

5

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23 August 2017

9 September 2010

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23 August 2017

Toxicological Sciences

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23 August 2017

119

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23 August 2017

2

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23 August 2017

245-256

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Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research

23 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Apoptotic pathways of oxidative damage to renal tubular epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

"Simple but not simpler": toward a unified picture of energy requirements in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Cathepsin-regulated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

A role for superoxide in gentamicin-mediated nephropathy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Potential therapeutic effect of antioxidant therapy in shock and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Death by design: apoptosis, necrosis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Concentrations of gentamicin and amikacin in human kidneys

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

A novel method for the evaluation of proximal tubule epithelial cellular necrosis in the intact rat kidney using ethidium homodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Gentamicin alters membrane structure as shown by freeze-fracture of liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Nitric oxide and oxidative stress in vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Regulation of apoptosis by the unfolded protein response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Cell death by necrosis: towards a molecular definition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Roles of hemodynamic and tubular factors in gentamicin-mediated nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Prostacyclin protects renal tubular cells from gentamicin-induced apoptosis via a PPARalpha-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Chemical hypoxia-induced cell death in human glioma cells: role of reactive oxygen species, ATP depletion, mitochondrial damage and Ca2+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Inhibition of in vitro endosomal vesicle fusion activity by aminoglycoside antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Cytokine cooperation in renal tubular cell injury: the role of TWEAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Effects of co-supplementation of vitamins E and C on gentamicin-induced nephrotoxicity in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Drug-phospholipid interactions: role in aminoglycoside nephrotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

TRPV4 enhances the cellular uptake of aminoglycoside antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Effect of tempol (4-hydroxy tempo) on gentamicin-induced nephrotoxicity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

The calpain, caspase 12, caspase 3 cascade leading to apoptosis is altered in F508del-CFTR expressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Endoplasmic reticulum stress: signaling the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Decreased renal uptake of (99m)Tc-DMSA in patients with tubular proteinuria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on gentamicin-induced renal tubular toxicity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Transgenic expression of proximal tubule peroxisome proliferator-activated receptor-alpha in mice confers protection during acute kidney injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

PPARα ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Peroxisomal proliferator-activated receptor-alpha protects renal tubular cells from doxorubicin-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Potential role of platelet activating factor in acute renal failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Involvement of reactive oxygen species on gentamicin-induced mesangial cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Glomerular nephrotoxicity of aminoglycosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Molecular parameters involved in aminoglycoside nephrotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Protective effect of trans-resveratrol on gentamicin-induced nephrotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Lipid rafts and oxidative stress-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Cytoplasmic and intra-nuclear binding of gentamicin does not require endocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Effect of gentamicin on pharmacokinetics of lysozyme in rats: interaction between megalin substrates in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Mitochondria, oxidative stress and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Gentamicin-induced preconditioning of proximal tubular LLC-PK1 cells stimulates nitric oxide production but not the synthesis of heat shock protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Effect of endoplasmic reticulum stress preconditioning on cytotoxicity of clinically relevant nephrotoxins in renal cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Basis for prokaryotic specificity of action of aminoglycoside antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Mechanisms of cell death in oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Turning point in apoptosis/necrosis induced by hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Effect of hypoxia on susceptibility of RGC-5 cells to nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Megalin Deficiency Offers Protection from Renal Aminoglycoside Accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Mitochondria and energetic depression in cell pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Autoradiography of gentamicin uptake by the rat proximal tubule cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Determinants of social outcome measured by the Frenchay Activities Index at one year after stroke onset

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Long-term protection of polyaspartic acid in experimental gentamicin nephrotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Aminoglycoside antibiotics alter the electrogenic transport properties of cultured human proximal tubule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Recent updates on the calcium-sensing receptor as a drug target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Nephrotoxicity of aminoglycoside antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Aminoglycosides induce acute cell signaling and chronic cell death in renal cells that express the calcium-sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ267

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFQ267

1 reference

23 August 2017

1 reference