(Q37791426)

23 August 2017

title

The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization (English)

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23 August 2017

1

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ORCID Public Data File 2021

23 August 2017

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author name string

F M Helwani

series ordinal

2

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23 August 2017

I G Winkler

series ordinal

3

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23 August 2017

language of work or name

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23 September 2010

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23 August 2017

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23 August 2017

volume

24

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23 August 2017

issue

12

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23 August 2017

page(s)

1979-1992

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https://scigraph.springernature.com/pub.10.1038/leu.2010.214

23 August 2017

exact match

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cites work

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Niche recycling through division-independent egress of hematopoietic stem cells

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Haematopoietic stem cell release is regulated by circadian oscillations

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Mechanisms of hematopoietic stem cell mobilization: when innate immunity assails the cells that make blood and bone

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Stem-cell ecology and stem cells in motion

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In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

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CD44 is a physiological E-selectin ligand on neutrophils

21 January 2018

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The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.214

Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.214

Integrin alpha4beta7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.214

Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Interaction between integrin alpha9beta1 and vascular cell adhesion molecule-1 (VCAM-1) inhibits neutrophil apoptosis

21 January 2018

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Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.214

PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

PTX-sensitive signals in bone marrow homing of fetal and adult hematopoietic progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Galpha(s) uncouples hematopoietic stem cell homing and mobilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Serpina1 is a potent inhibitor of IL-8-induced hematopoietic stem cell mobilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Characterization of hematopoietic progenitor mobilization in protease-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Plasmin therapy enhances mobilization of HPCs after G-CSF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Hepatocyte growth factor is secreted by osteoblasts and cooperatively permits the survival of haematopoietic progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Osteoblastic cells regulate the haematopoietic stem cell niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Identification of the haematopoietic stem cell niche and control of the niche size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Detection of functional haematopoietic stem cell niche using real-time imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

On the adaptation of endosteal stem cell niche function in response to stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Skeletal homeostasis in tissue-engineered bone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

An in vivo model to study and manipulate the hematopoietic stem cell niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Uncertainty in the niches that maintain haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Hematopoiesis is severely altered in mice with an induced osteoblast deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

What is the true nature of the osteoblastic hematopoietic stem cell niche?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Modeling pO(2) distributions in the bone marrow hematopoietic compartment. I. Krogh's model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors

21 January 2018

2 references

https://api.crossref.org/works/10.1038%2FLEU.2010.214

21 January 2018

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Treatment of normal individuals with granulocyte-colony-stimulating factor: donor experiences and the effects on peripheral blood CD34+ cell counts and on the collection of peripheral blood stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Clinical toxicity of cytokines used as haemopoietic growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Mobilized hematopoietic stem cell yield depends on species-specific circadian timing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Cooperation of beta(2)- and beta(3)-adrenergic receptors in hematopoietic progenitor cell mobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

HIF-1alpha is essential for myeloid cell-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Fifth complement cascade protein (C5) cleavage fragments disrupt the SDF-1/CXCR4 axis: further evidence that innate immunity orchestrates the mobilization of hematopoietic stem/progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Modulation of the SDF-1-CXCR4 axis by the third complement component (C3)--implications for trafficking of CXCR4+ stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

The role of complement C3 opsonization, C5a receptor, and CD14 in E. coli-induced up-regulation of granulocyte and monocyte CD11b/CD18 (CR3), phagocytosis, and oxidative burst in human whole blood.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

G-CSF increases mesenchymal precursor cell numbers in the bone marrow via an indirect mechanism involving osteoclast-mediated bone resorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Of lineage and legacy: the development of mammalian hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Embryonic development of the human hematopoietic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Spatial gradients of blood vessels and hematopoietic stem and progenitor cells within the marrow cavities of the human skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

BMP4 regulates the hematopoietic stem cell niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Origin of Repopulating Cells after Localized Bone Marrow Depletion

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Mobilization of bone marrow-derived progenitors

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Neutrophil-derived MMP-9 mediates synergistic mobilization of hematopoietic stem and progenitor cells by the combination of G-CSF and the chemokines GRObeta/CXCL2 and GRObetaT/CXCL2delta4

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Proteolytic enzyme levels are increased during granulocyte colony-stimulating factor-induced hematopoietic stem cell mobilization in human donors but do not predict the number of mobilized stem cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

In vivo activity of the cleaved form of soluble urokinase receptor: a new hematopoietic stem/progenitor cell mobilizer

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Thrombus stability on the vessel wall

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts*1

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Resolving the controversy about N-cadherin and hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Therapeutic targeting of a stem cell niche

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.214

7 January 2021

Identifiers

DOI

10.1038/LEU.2010.214

1 reference

Dimensions Publication ID

23 August 2017

1021969475

0 references

1 reference