(Q37805521)

23 August 2017

title

Radiation-induced genomic instability: are epigenetic mechanisms the missing link? (English)

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23 August 2017

Umut Aypar

1

1 reference

23 August 2017

William F Morgan

series ordinal

2

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23 August 2017

Janet E Baulch

series ordinal

3

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23 August 2017

publication date

2 November 2010

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International Journal of Radiation Biology

23 August 2017

published in

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23 August 2017

volume

87

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23 August 2017

issue

2

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23 August 2017

page(s)

179-191

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HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.

23 August 2017

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Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells.

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Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation

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Chromatin dynamics during DSB repair

21 January 2018

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Chromatin structure influences the sensitivity of DNA to gamma-radiation

21 January 2018

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DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms

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H2AX: the histone guardian of the genome

21 January 2018

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GammaH2AX and its role in DNA double-strand break repair

21 January 2018

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Oxidative stress, DNA methylation and carcinogenesis.

21 January 2018

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Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2

21 January 2018

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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

21 January 2018

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The characteristics of DNA methylation in an in vitro DNA synthesizing system from mouse fibroblasts

21 January 2018

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Epigenetic changes in cancer

21 January 2018

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DNA methylomes, histone codes and miRNAs: tying it all together

21 January 2018

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Gene silencing in cancer in association with promoter hypermethylation

21 January 2018

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Delayed chromosomal instability in human T-lymphocyte clones exposed to ionizing radiation

21 January 2018

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ATM is down-regulated by N-Myc-regulated microRNA-421.

21 January 2018

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Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner

21 January 2018

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Radiation-induced response of micro RNA expression in murine embryonic stem cells.

21 January 2018

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Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila

21 January 2018

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Environmental epigenomics and disease susceptibility

21 January 2018

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https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Worms gang up on bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

The epigenomics of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Radiation-induced genomic instability is associated with DNA methylation changes in cultured human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability

21 January 2018

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https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Epigenetic gene silencing in the Wnt pathway in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo.

21 January 2018

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https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Stable loss of global DNA methylation in the radiation-target tissue--a possible mechanism contributing to radiation carcinogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Epigenetic changes and nontargeted radiation effects--is there a link?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Genome hypermethylation in Pinus silvestris of Chernobyl—a mechanism for radiation adaptation?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Chromatin-remodelling mechanisms in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Interleukin 8 exhibits a pro-mitogenic and pro-survival role in radiation induced genomically unstable cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

The nuclear RNase III Drosha initiates microRNA processing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

MicroRNA maturation: stepwise processing and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

MicroRNA genes are transcribed by RNA polymerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Chromosomal instability induced by heavy ion irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

21 January 2018

Radiation carcinogenesis

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Changes in MicroRNA expression patterns in human fibroblasts after low-LET radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Delayed chromosomal instability induced by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Profiling mitochondrial proteins in radiation-induced genome-unstable cell lines with persistent oxidative stress by mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: I. Radiation-Induced Genomic Instability and Bystander EffectsIn Vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: II. Radiation-Induced Genomic Instability and Bystander EffectsIn Vivo,Clastogenic Factors and Transgenerational Effects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

DNA double-strand breaks, chromosomal rearrangements, and genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Bystander effects in radiation-induced genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

The death-inducing effect and genomic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Variable effects of DNA-synthesis inhibitors upon DNA methylation in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Chromosomal instability and alteration of telomere repeat sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

The evolution of chromosomal instability in Chinese hamster cells: a changing picture?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

The ever expanding role for c-Myc in promoting genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Co-evolution of X-chromosome inactivation and imprinting in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Multiple manifestations of X-ray-induced genomic instability in Chinese hamster ovary (CHO) cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Hypoxia relieves X-ray-induced delayed effects in normal human embryo cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

DNA, FISH and complementation studies in ICF syndrome: DNA hypomethylation of repetitive and single copy loci and evidence for a trans acting factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Ionizing radiation-induced oxidative stress alters miRNA expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Radiation-induced chromosomal instability and gene expression profiling: searching for clues to initiation and perpetuation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Differential induction and activation of NF-kappaB transcription complexes in radiation-induced chromosomally unstable cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Lack of consensus gene expression changes associated with radiation-induced chromosomal instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

microRNAs in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Radiation-induced genomic instability: a role for secreted soluble factors in communicating the radiation response to non-irradiated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Role of H2AX in DNA damage response and human cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Effects of X-ray irradiation on genomic DNA methylation levels in mouse tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Radiation-induced instability and its relation to radiation carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Classical radiation biology dogma, bystander effects and paradigm shifts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Chromatin remodeling and cancer, Part I: Covalent histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Manifestations and mechanisms of non-targeted effects of ionizing radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

The sticky business of histone H2AX in V(D)J recombination, maintenance of genomic stability, and suppression of lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Epigenetics, oxidative stress, and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Histone H2A ubiquitination in transcriptional regulation and DNA damage repair

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

Transmission of chromosomal instability after plutonium α-particle irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09553002.2010.522686

10.3109/09553002.2010.522686

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference